Prognostic Significance of Survivin in Breast Cancer: Meta-analysis

Li, Yanyan; Ma, Xuelei; Wu, Xi; Liu, Huan; Liu, Lei

doi:10.1111/tbj.12303

Cited by 33 publications

(33 citation statements)

References 39 publications

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“…Adida et al reported that survivin expression in neuroblastoma correlated with unfavorable histology and aggressive and disseminated disease [15]. In colorectal cancer and breast cancer, patients with surviving-positive tumors had a decreased apoptotic index and worse survival rates than those with survivin-negative tumors [17, 27]. In addition, survivin expression was correlated with poor prognosis in esophageal cancer and non-small cell lung cancer [19, 20].…”

Section: Discussionmentioning

confidence: 99%

Survivin expression and serum levels in pancreatic cancer

et al. 2015

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BackgroundSurvivin, an inhibitor of apoptosis, is overexpressed in pancreatic ductal adenocarcinoma (PDAC). Its expression is known to be associated with poor clinical outcome. However, to our knowledge, there has been no study to characterize its usefulness as a serum marker for human pancreatic cancer. Furthermore, the relation between survivin expression and the serum level of survivin has not been widely studied in PDAC. We performed this study to investigate the expression and serum level of survivin in PDAC and its clinical significance as a prognostic factor.MethodsWe performed immunohistochemical staining for survivin in formalin-fixed, paraffin-embedded blocks from 80 PDAC tissues. The serum level of survivin from the patients (n = 80) and age-matched healthy volunteers (n = 80) were analyzed by enzyme-linked immunosorbent assays (ELISAs) prior to surgical resection. Levels of expression were correlated with clinicopathological parameters.ResultsSerum survivin concentrations were significantly elevated in patients with PDAC when compared with healthy sera (P < 0.001). High serum survivin levels were significantly associated with perineural invasion, venous invasion, lymph node status (N stage), cell differentiation, and recurrence but not with the tumor size, age, gender of the patients, or tumor location. The median overall survival time of the group with normal serum survivin levels was longer than that of the group with elevated serum survivin. The independent factors associated with overall survival were advanced pancreatic cancer and elevated serum survivin level. Of the 80 cases of PDAC, 65 (81.25 %) were positive for survivin expression. There were significant associations between survivin expression and perineural invasion, venous invasion, and lymph node status. A significant difference in overall survival was associated with survivin expression.ConclusionsPatients with elevated serum survivin level and high survivin expression at diagnosis demonstrated a poor outcome. Detection of serum survivin or tissue survivin expression may predict the prognosis of patients with PDAC.

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Section: Discussionmentioning

confidence: 99%

Survivin expression and serum levels in pancreatic cancer

et al. 2015

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“…Meta-analysis was conducted to find relationships between positive survivin expression and poor overall survival in breast cancer and lymph node metastasis patients. Overexpression of survivin indicated a significantly higher risk of recurrence and reduced overall survival 59,60…”

Section: Embasementioning

confidence: 99%

Identification of Biomarkers for Breast Cancer Using Databases

Lee

Moon

2016

J Cancer Prev

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Breast cancer is one of the major causes of cancer death in women. Many studies have sought to identify specific molecules involved in breast cancer and understand their characteristics. Many biomarkers which are easily measurable, dependable, and inexpensive, with a high sensitivity and specificity have been identified. The rapidly increasing technology development and availability of epigenetic informations play critical roles in cancer. The accumulated data have been collected, stored, and analyzed in various types of databases. It is important to acknowledge useful and available data and retrieve them from databases. Nowadays, many researches utilize the databases, including The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Surveillance, Epidemiology and End Results (SEER), and Embase, to find useful informations on biomarkers for breast cancer. This review summarizes the current databases which have been utilized for identification of biomarkers for breast cancer. The information provided by this review would be beneficial to seeking appropriate strategies for diagnosis and treatment of breast cancer.

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“…Positive expression of survivin in breast cancer predicted a significantly higher risk of disease recurrence and is shown to be associated with lymph node metastasis (P value = 0.01) [16]. The rate of survivin expression seems to correlate with the sensitivity of survivin detection methods.…”

Section: Survivinin Breast Cancermentioning

confidence: 96%