Prognostic Significance of Stem Cells Tumors and Alk Expression in Patients With Primary Skinmelanoma

Titov, K.S.; Baryshnikova, M.A.; Казаков, А. М.; Khochenkov, Dmitry; Larionova, E.P.; Ryabchikov, D. A.

doi:10.31917/2001072

Cited by 2 publications

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“…В связи с этим изучение фенотипа ОСК, сигнальных путей, микросреды -неотъемлемая ступень к пониманию процессов формирования лекарственной резистентности меланомы кожи. Таким образом, глобальной целью перед мировым научным сообществом на сегодняшний день является разработка лечебных стратегий по элиминации популяции резистентных ОСК для достижения полного контроля над заболеванием, которое остается одной из ведущих причин смертности во всем мире [10,11].…”

Section: Introductionunclassified

The role of tumor stem cells in the development of drug resistance of melanoma

Chulkova

Маркина²,

Чернышева³

et al. 2019

Rossijskij bioterapevtičeskij žurnal

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Despite the fact that melanoma is a tumor of visual localization, mortality from skin melanoma remains one of the leading causes of mortality worldwide. Early metastasis of melanoma, even during the initial stages of the tumor process, indicates a high malignant potential of the tumor. Moreover, metastatic melanoma is resistant to current chemotherapy regimens, which is a significant problem today. Progression, resistance to drug therapy of skin melanoma is associated with a population of tumor stem cells, which are characterized by dysregulation of signaling pathways and aberrant phenotypes. The formation of tumor stem cells contributes to their microenvironment. Surface markers expressed by tumor stem cells include transporter proteins that mediate chemoresistance. The study of the microenvironment, the activity of the expressed antigenic determinants makes it possible to understand the processes of chemoresistance formation and to discover (develop) strategies for its overcoming. The article provides an analysis of the literature data on the significance of tumor stem cells in the development of drug resistance of melanoma.

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Section: Introductionunclassified

The role of tumor stem cells in the development of drug resistance of melanoma

Chulkova

Маркина²,

Чернышева³

et al. 2019

Rossijskij bioterapevtičeskij žurnal

View full text Add to dashboard Cite

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The role of a new <i>ALK</i> isoform in the diagnosis and targeted therapy of skin melanoma

Titov

Маркин

Казаков

et al. 2021

Rossijskij bioterapevtičeskij žurnal

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Contemporary discoveries of fundamental science in recent decades in the field of oncology have led to the emergence of new highly effective anticancer drugs: targeted drugs and immune checkpoint inhibitors, use of which has made a breakthrough in the treatment of oncological diseases, including skin melanoma. Melanoma is still one of the most cancerous tumors. The number of patients resistant to targeted therapy and immunotherapy increases in the world every year. Oncologists have practically no leverage to influence the disease after the development of resistance to this type of therapy. In this regard, scientists around the world are looking for new application points for targeted drugs. Nowadays, the most common treatment method is BRAF inhibitors, since the BRAF mutation is detected in 40–60 % of patients with skin melanoma. However, the resistance to BRAF inhibitor therapy occur in half cases after 6–8 months. To overcome the resistance to the target therapy is one the most important issue, the studying of new isoform of anaplastic lymphoma kinase (ALK) may help to solve this problem.Purpose of the study – to order the data of the leading researchers of a new isoform of ALK, and reveal the most promising directions for its further progress.In the article, there are comparisons and analyses the 6 of the largest studies over the past 5 years devoted to a new isoform of ALK.The joint inhibition of the new ALK isoform and BRAFV600 showed positive results in several studies with different levels of ALKATI expression (alternative initiation of ALK transcription). The new ALK isoform can stimulate oncogenesis only within a certain “threshold” level of expression. Immunohistochemical examination cannot be the main method for determining the expression of a new ALK isoform due to low sensitivity. In almost all studies, tumors with ALK translocation responded to therapy with ALK inhibitors.Even though that the role of the new ALK isoform has been studied in recent years, the optimal method for evaluating the expression of ALKATI in routine practice has not yet been determined. Additional studies are also needed to understand the effectiveness of the use of ALК inhibitors in combination with BRAF and ERK inhibitors. Of interest is the blockade of extracellular vesicles and the study of the role of interleukin-3 in the inhibition of ALKATI.

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Prognostic Significance of Stem Cells Tumors and Alk Expression in Patients With Primary Skinmelanoma

Cited by 2 publications

References 1 publication

The role of tumor stem cells in the development of drug resistance of melanoma

The role of tumor stem cells in the development of drug resistance of melanoma

The role of a new <i>ALK</i> isoform in the diagnosis and targeted therapy of skin melanoma

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