Prognostic significance of stathmin expression in correlation with metastasis and clinicopathological characteristics in human ovarian carcinoma

Wei, Sanhua; Lin, Fang; Wang, Xi; Gao, Peng; Zhang, Huizhong

doi:10.1016/j.acthis.2007.06.002

Cited by 37 publications

(29 citation statements)

References 18 publications

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“…It has been reported to use these keratins as diagnostic markers with immunostaining (Chu and Weiss 2002) or as serological tumor markers to monitor cancer load, progression, and response to therapy (Linder 2007). Stathmin is a microtubule-destabilizing protein ubiquitously expressed in vertebrates and overexpressed in a variety of human malignancies (Kouzu et al 2006;Wei et al 2008). Studies have demonstrated that Stathmin expression correlates with hepatocarcinogenesis and tumor progression, and suggested that overexpression of this gene could predict early tumor recurrence and poor prognosis of hepatoma (Hsieh et al 2010;Gan et al 2010).…”

Section: Discussionmentioning

confidence: 94%

Candidate genes involving in tumorigenesis of cholangiocarcinoma induced by Opisthorchis viverrini infection

Boonmars

Boonjaraspinyo

et al. 2011

Parasitol Res

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Opisthorchiasis-associated cholangiocarcinoma (CCA) is one of main public health problems in Opisthorchis viverrini endemic areas. Although the definite relationship between prevalence of CCA and the parasite infection has been demonstrated, the molecular mechanism of tumorigenesis is still unknown. In the present study, by using animal model of opisthorchiasis-associated CCA, a kinetic analysis of cDNA microarray was performed to screen the candidate genes that involve in the development of opisthorchiasis-associated CCA. Microarray analysis revealed that the expressions of 131 genes were up-regulated during the development of CCA, including the genes relative to cell proliferation, differentiation and transformation, cell growth and cycle regulation, apoptosis, DNA repair, and cytoskeletal structure. The expressions of 145 genes were down-regulated, including the genes relative to metabolic enzymes, tumor suppressor, apoptosis, and oxidative response and oxidation reduction. The present study listed up the candidate genes involving tumorigenesis, provided molecular information on the development of opisthorchiasis-associated CCA and the potential biomarkers for diagnosis and therapy, and suggested that the increased expression of cell differentiation, proliferation, transformation-related genes, and decreased expression of metabolic enzymes may play important roles in the tumorigenesis of CCA.

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Section: Discussionmentioning

confidence: 94%

Candidate genes involving in tumorigenesis of cholangiocarcinoma induced by Opisthorchis viverrini infection

Boonmars

Boonjaraspinyo

et al. 2011

Parasitol Res

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“…Differential expression of stathmin has repeatedly been described in various cancer types, such as leukaemia (Melhem et al 1991), lung adenocarcinoma (Chen et al 2003), oral squamous-cell carcinoma (Kouzu et al 2006), hepatocellular carcinoma (Yuan et al 2006), ovarian cancer (Wei et al 2008), breast cancer (Alli et al 2007bBrattsand 2000), Wilms tumours (Takahashi et al 2002), and glioblastoma multiforme (Ngo et al 2007). Stathmin overexpression was associated with poor outcome and a more malignant phenotype.…”

Section: Discussionmentioning

confidence: 95%

“…In hepatocellular carcinoma, elevated stathmin levels were accompanied by a more aggressive behaviour (Yuan et al 2006). Metastatic cases of ovarian cancer harboured higher levels of stathmin (Wei et al 2008). In a mouse glioblastoma multiforme model, stathmin was correlated with poor survival and resistance to nitrosourea compounds (Ngo et al 2007).…”

Section: Discussionmentioning

confidence: 96%

Identification of c-myc-dependent proteins in the medulloblastoma cell line D425Med

Azizi

Ströbel

et al. 2011

Amino Acids

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High c-myc levels are linked to poor prognosis in medulloblastoma (MB), and it was the aim of the current study to search for c-myc-dependent proteins in the MB cell line D425Med. For this purpose D425Med cells and cells with knocked-down c-myc (by siRNA) were analysed by a gel-based differential proteomics study using mass spectrometry. Heterogeneous nuclear ribonucleoproteins C1/C2, heterogeneous nuclear ribonucleoprotein A/B, stathmin, endoplasmic reticulum protein ERp29 precursor and guanidinoacetate N-methyltransferase were c-myc dependently expressed. Signalling, the protein machinery, metabolism and endoplasmic reticulum function may be affected and these results enable studying tumour tissue for these proteins as potential dignity markers or pharmacological targets.

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“…Many reports have shown that stathmin is overexpressed in a variety of human malignancies such as acute leukemia, breast carcinoma and lung cancer (Melhem et al 1997;Bièche et al 1998;Chen et al 2003). In our previous study, stathmin was also found to be overexpressed in osteosarcoma and ovarian carcinoma cells, and the overexpression of this gene signiWcantly correlated with prognosis of patients (Zhang et al 2004;Wei et al 2008). Moreover, we found that small interfering RNA (siRNA) or antisense-mediated downregulation of stathmin expression could lead to proliferation inhibition and chemosensitivity enhancement in human osteosarcoma cells (Zhang et al 2006;Wang et al 2007).…”

mentioning

confidence: 92%

Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients

Wang

Lin

et al. 2008

J Cancer Res Clin Oncol

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Prognostic significance of stathmin expression in correlation with metastasis and clinicopathological characteristics in human ovarian carcinoma

Cited by 37 publications

References 18 publications

Candidate genes involving in tumorigenesis of cholangiocarcinoma induced by Opisthorchis viverrini infection

Candidate genes involving in tumorigenesis of cholangiocarcinoma induced by Opisthorchis viverrini infection

Identification of c-myc-dependent proteins in the medulloblastoma cell line D425Med

Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patients

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