Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma

Poon, Ronnie Tung‐Ping; Ho, Joanna W.; Tong, Chi-Chung; Lau, CK; Ng, Irene Oi–Lin; Fan, Sheung Tat

doi:10.1002/bjs.4594

Cited by 205 publications

(136 citation statements)

References 38 publications

(44 reference statements)

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“…Patients with high serum VEGF levels had significantly worse overall survival compared with those with low serum VEGF levels (P=0.002) (Figure 3), in accordance with previous studies [12] Figure 2. Overall survival curves after the first TACE or TAI in the 60 patients.…”

Section: Prognostic Significance Of Serum Vegf Levelssupporting

confidence: 90%

Impact of serum vascular endothelial growth factor on prognosis in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

Guo

Zhu

et al. 2012

Chin. J. Cancer Res.

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Objective: To investigate the expression level of serum vascular endothelial growth factor (VEGF) in patients with unresectable hepatocellular carcinoma (HCC) and its relationship with the clinicopathological characteristics, and to assess the impact of serum VEGF as a predictive factor for HCC prognosis during transarterial chemoembolization (TACE) treatments.Methods: Serum VEGF levels were measured using enzyme-linked immunosorbent assay (ELISA) in 60 random patients who underwent TACE or transarterial infusion (TAI) for unresectable HCC between May and September 2008 and 12 healthy volunteers were also involved in this study to serve as control. All patients' clinicopathological features were retrospectively analyzed. Serum VEGF levels were correlated with clinicopathological features of the HCC patients. The patients' survival rates were analyzed with Kaplan-Meier survival curves and compared by the log-rank test. The prognostic significance of serum VEGF levels and factors related to survival rate were evaluated by univariate and multivariate analysis.Results: The median serum VEGF level in the HCC patients was 285 pg/ml (range 14−1,207 pg/ml), significantly higher than that of healthy controls (P=0.021). The serum VEGF levels were significantly correlated with platelet counts (r=0.396, P=0.002) but not other clinicopathological features. Patients with serum VEGF level >285 pg/ml had worse overall survival compared with those with serum VEGF level <285 pg/ml (P=0.002). By multivariate analysis, the serum VEGF level was a significant prognostic factor.Conclusion: High serum VEGF levels may predict poor prognosis of HCC after TACE. This study highlights the importance of tumor biomarker as a prognostic predictor in TACE therapy for HCC, which has an intrinsic problem of unavailability of histopathological prognostic features.

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Section: Prognostic Significance Of Serum Vegf Levelssupporting

confidence: 90%

Impact of serum vascular endothelial growth factor on prognosis in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

Guo

Zhu

et al. 2012

Chin. J. Cancer Res.

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“…In total, there were four tissue OS studies (Chow et al, 1997;Jeng et al, 2004a;Deli et al, 2005;Sheen et al, 2005), six tissue DFS studies (Jeng et al, 2004a;Sheen et al, 2005;Guo et al, 2006;Wada et al, 2006;Zhang et al, 2006;Ho et al, 2007), seven serum OS studies (Poon et al, 2001(Poon et al, , 2004a(Poon et al, , b, 2007Chao et al, 2003;Kim et al, 2004;Jeng et al, 2004b;Treiber et al, 2006), and five serum DFS studies (Poon et al, 2001(Poon et al, , 2007Chao et al, 2003;Jeng et al, 2004b;Treiber et al, 2006). Pooled HRs were then calculated for all groups.…”

Section: Summary Estimates Of Primary Studiesmentioning

confidence: 99%

“…Although not entirely unexpected given the high burden of HCC in Asian populations (El-Serag, 2002), this raises a question regarding external validity of results and applicability to Western societies. However, multiple tissue (Jeng et al, 2004a;Sheen et al, 2005;Ho et al, 2007) and serum (Poon et al, 2001(Poon et al, , 2004a studies failed to find a relationship between chronic viral hepatitis status and VEGF levels. This is somewhat reassuring given the high prevalence of this liver disease aetiology in Asia.…”

Section: Test For Heterogeneitymentioning

confidence: 99%

Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis

et al. 2009

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Hepatocellular carcinoma (HCC) is a highly vascular tumour that expresses vascular endothelial growth factor (VEGF). Various studies have evaluated the prognostic value of VEGF levels in HCC. Its overall test performance remains unclear, however. The aim was to perform a systematic review and meta-analysis of prognostic cohort studies evaluating the use of VEGF as a predictor of survival in patients with treated HCC. Eligible studies were identified through multiple search strategies. Studies were assessed for quality using the Newcastle–Ottawa Tool. Data were collected comparing disease-free and overall survival in patients with high VEGF levels as compared to those with low levels. Studies were pooled and summary hazard ratios were calculated. A total of 16 studies were included for meta-analysis (8 for tissue and 8 for serum). Methodological analysis indicated a trend for higher study quality with serum studies as compared to tissue-based investigations. Four distinct groups were pooled for analysis: tissue overall survival ( n =251), tissue disease-free survival ( n =413), serum overall survival ( n =579), and serum disease-free survival ( n =439). High tissue VEGF levels predicted poor overall (HR=2.15, 95% CI: 1.26–3.68) and disease-free (HR=1.69, 95% CI: 1.23–2.33) survival. Similarly, high serum VEGF levels predicted poor overall (HR=2.35, 95% CI: 1.80–3.07) and disease-free (HR=2.36, 95% CI 1.76–3.16) survival. A high degree of inter-study consistency was present in three of four groups analysed. Tissue and serum VEGF levels appear to have significant predictive ability for estimating overall survival in HCC and may be useful for defining prognosis in HCC.

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“…Tissue expression of VEGF correlates well with tumour progression and has been shown to be of prognostic significance in many malignancies [5][6][7][8][9]. Serum VEGF level may be a surrogate marker of tumour VEGF expression in patients with osteosarcoma, as-similar to tissue expression-it has prognostic significance [10][11][12][13][14][15][16], with significant association between a high VEGF expression in the primary tumour and poor prognosis [17,18]. Due to the central role of VEGF in tumour angiogenesis, the VEGF-VEGF receptor (VEGFR) pathway has become a major focus of research and antiangiogenic drug development in oncology [3].…”

Section: Introductionmentioning

confidence: 99%

Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study

Rastogi

Kumar

Sankineani

et al. 2012

International Orthopaedics (SICOT)

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Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma

Abstract: A high serum level of VEGF is a predictor of poor outcome after resection of HCC. Serum VEGF, but not endostatin, may be a useful prognostic marker in patients with HCC.

Cited by 205 publications

References 38 publications

Impact of serum vascular endothelial growth factor on prognosis in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

Impact of serum vascular endothelial growth factor on prognosis in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis

Role of vascular endothelial growth factor as a tumour marker in osteosarcoma: a prospective study

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