Prognostic significance of serum vascular endothelial growth factor and Angiopoietin-2 in patients with lung cancer

P, Akın Kabalak; Çiledağ, Aydın; Demir, Neclå; Çelik, Gökhan; Yüksel, Cabir; Köycü, Gözde; D, Gökmen Öztuna; A, Taner; Kaya, Abit; Kutlay, Hakan; Numanoğlu, Numan; Savaş, İsmail

doi:10.5578/tt.9015

Cited by 10 publications

(12 citation statements)

References 11 publications

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“…Finally, 20 studies with 1911 patients in total matched the criteria and were included in the present study. [ 15 , 19 – 37 ] The flow chart summarizing the systematic literature selection process is shown in Figure 1 . Based on the NOS score (Table 1 ), each study was considered high quality.…”

Section: Resultsmentioning

confidence: 99%

The role of serum angiopoietin-2 levels in progression and prognosis of lung cancer

Wang

Chen

et al. 2017

Medicine

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Background:Angiogenesis is an essential process in the development and progression of malignant tumors including lung cancer, in which angiopoietin-2 (Ang-2) plays an important role. The objective of this study was to assess the prognostic value of serum Ang-2 levels in patients with lung cancer.Methods:A comprehensive systematic electronic search was performed in the Pubmed, Embase, Web of Science, china national knowledge infrastructure, and VIP databases update to October, 2016 (qikan.cqvip.com). Literatures examining the relevance of serum Ang-2 levels to progression and prognosis of lung cancer were eligible for our study. Standardized mean differences (SMD) with 95% confidence interval (95% CI) and a P value were applied to compare continuous variables, and hazard ratio (HR) with 95% CI as well as P value were applied for prognostic role.Results:Twenty studies with 1911 patients met the eligibility criteria. Among them, 7 studies with 575 patients with lung cancer assessed the association between expression of serum Ang-2 and prognosis. According to our results, higher levels of serum Ang-2 were associated with the later stage of tumor. Serum Ang-2 levels were significantly lower in stage I than in stage II (SMD: −0.51; 95% CI: −0.75 to −0.27; P < .001), in stage II than in stage III (SMD: −0.52; 95% CI: −0.80 to −0.24; P < .001), in stage III than in stage IV (SMD: −0.58; 95% CI: −0.93 to −0.23; P = .001). In addition, serum Ang-2 levels were higher in patients with lymph node metastasis (SMD: 1.06; 95% CI, 0.57–1.56; P < .001). Meanwhile, patients with lung cancer with higher levels of serum Ang-2 were associated with a significant poorer prognosis when compared to those with lower serum Ang-2 levels (HR: 1.64; 95% CI: 1.20–2.25; P = .002), and this role was further detected when stratified by ethnicity and histological type.Conclusions:This systematic review and meta-analysis suggested that serum Ang-2 levels might be a potential predictor for staging, and were associated with prognosis of lung cancer.

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Section: Resultsmentioning

confidence: 99%

The role of serum angiopoietin-2 levels in progression and prognosis of lung cancer

Wang

Chen

et al. 2017

Medicine

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“…There are no correlations between separate indexes of ARPB and such tumor markers as osteopontin, osteocalcin and fibronectin. In turn, with all the parameters of ARPB without exception, there are direct relations between the level of VEGF, which, in addition to the prognostic factor of high aggression of LC [14][15][16], is an important component in the development of neoangiogenesis in such patients [17]. In addition to the above, VV positively correlates with TGFβ1 (r = +0.197, p = 0.035) and C-reactive protein (r = +0.293, p = 0.002), and ST and SR directly correlates with TGFβ1 (respectively R = +0.209, p = 0.025 and r = +0.191, p = 0.042) and inversely with α 2 -macroglobulin (r = −0.190, p = 0.042 and r = −0.266, p = 0.004).…”

Section: Resultsmentioning

confidence: 99%

Adsorption-Rheological Properties of Blood Serum in Lung Cancer Patients

Dumanskiy¹,

Stoliarova²,

Syniachenko³

et al. 2017

Exp. Onc.

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The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. Patients and Methods: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women. The parameters of surface (interfacial) viscosity, elasticity, viscoelasticity module, tension and relaxation of blood serum were studied by the oscillating drop method using a computer tensiometer “PAT2-Sinterface”, and its volumetric viscosity was investigated using a Low-Shear-30 rotational viscometer. ARPB parameters were also studied in a control group composed from 50 healthy donors. Results: Increased levels of volumetrical viscosity, surface tension, surface elasticity and the relaxation time of the blood are typical for patients with LC and depended on the localization of the tumor, its histological variant, differentiation grade, severity of the course of the disease, the number of metastases in the lymph nodes, distant organs and skeleton, involvement of the pleura and ribs, the development of compression pulmonary syndrome, metastasis into the spine, adrenals, brain, and pancreas. The surface-active, viscoelastic and relaxation properties of the blood correlated with the levels of tumor markers (TGFβ1, VEGF, C-reactive protein, α2-macroglobulin). Conclusions: Integral changes of ARPB observed in every fifth patient with LC are involved in the pathogenesis of the disease, have predictive value in relation to the clinical course of disease (volumetric viscosity) and the development of complications from radiochemotherapy (surface viscosity).

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“…The change of the membrane permeability is also the trigger causing distal organ injury . It was demonstrated that when the intestinal mucosa was impaired, the pro‐inflammatory cytokines from intestinal would flow into intestinal lymphatic system, rendering the systemic inflammatory response, and exacerbating further injury of tissues and organs, which was closely associated with MODS. Many pathogenic mechanisms have been proposed to be involved in the gut barrier dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The effect of continuous blood purification on P38MAPK signaling pathway in patients with multiple organ dysfunction syndrome

Pan

2019

Clinical Laboratory Analysis

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Objective The aim of the study was to investigate the role of p38MAPK signaling pathway in patients with multiple organ dysfunction syndrome treated with continuous blood purification. Methods Blood samples were obtained to analyze the protein level of inflammatory factors (IL‐1, IL‐8, IL‐10, and TNF‐α) and phosphorylated p38MAPK by utilizing ELISA assay and Western blotting, respectively. The relative mRNA level of iNOS was detected by using RT‐PCR. In vitro study was conducted in Caco‐2 cells, which were treated with serum from patients subjected to continuous blood purification. Serum‐induced inflammatory factors and phosphorylated p38MAPK were also analyzed in Caco‐2 cells. Results The protein levels of IL‐1, IL‐8, IL‐10, and TNF‐α were significantly decreased in Caco‐2 cells treated with serum obtained from patients who were subjected to continuous blood purification therapy at the time course of 12 and 24 hours. A drastic decrease (P < 0.05) was observed in the level of IL‐8 and TNF‐α after continuous blood purification therapy in the patients treated with continuous blood purification therapy compared with control group. Conclusion Our study conducted in vivo and in vitro demonstrated that the continuous blood purification therapy could ameliorate the inflammatory response via activating the p38MAPK signaling pathway.

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Prognostic significance of serum vascular endothelial growth factor and Angiopoietin-2 in patients with lung cancer

Cited by 10 publications

References 11 publications

The role of serum angiopoietin-2 levels in progression and prognosis of lung cancer

The role of serum angiopoietin-2 levels in progression and prognosis of lung cancer

Adsorption-Rheological Properties of Blood Serum in Lung Cancer Patients

The effect of continuous blood purification on P38MAPK signaling pathway in patients with multiple organ dysfunction syndrome

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