“…25,27 Other variables with possible prognostic impact include tumor size, 28 patient sex, 29 older 29 or younger age, 8,30 proximal tumor site, 6,13 high alkaline phosphatase, 10,31 and high lactate dehydrogenase values. 10,32 More recently, prognostic significance was claimed for multidrug resistance status, 33 loss of heterozygosity of the RB gene, 34 and HER2/erbB-2 expression, 35,36 but these claims have yet to be substantiated by large-scale prospective studies.…”