Prognostic significance of serum inflammatory markers in esophageal cancer

Powell, Arfon; Eley, Catherine; Chin, Carven; Coxon, Alexandra; Christian, Adam; Lewis, Wyn G.

doi:10.1007/s10388-020-00772-3

Cited by 16 publications

(13 citation statements)

References 37 publications

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“…The role of inflammatory mediators, including C-reactive protein and neutrophil-to-lymphocyte ratio, on cancer recurrence has also been evaluated in patients with esophageal cancer. 26 Powell and colleagues 26 found that inflammatory mediators were independently associated with worse overall and diseasefree survival for patients undergoing esophagectomy with curative intent. In a recent systematic review of 17 569 patients who had developed recurrence following breast cancer surgery, 2077 patients were found to have a concomitant surgical site infection.…”

Section: Discussionmentioning

confidence: 99%

Association of Pharyngocutaneous Fistula With Cancer Outcomes in Patients After Laryngectomy

Davies

Hugh

Rich

et al. 2021

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Pharyngocutaneous fistula (PCF) results in an inflammatory reaction, but its association with the rate of locoregional and distant control, disease-free survival, and overall survival in laryngeal cancer remains uncertain.OBJECTIVE To determine if pharyngocutaneous fistula after salvage laryngectomy is associated with locoregional and distant control, disease-free survival, and/or overall survival. DESIGN, SETTING, AND PARTICIPANTSA multicenter collaborative retrospective cohort study conducted at 5 centers in Canada and the US of 550 patients who underwent salvage laryngectomy for recurrent laryngeal cancer from January 1, 2000, to December 31, 2014. The median follow-up time was 5.7 years (range, 0-18 years). MAIN OUTCOMES AND MEASURESOutcomes examined included locoregional and distant control, disease-free survival, and overall survival. Fine and Gray competing risk regression and Cox-proportional hazard regression models were used for outcomes. Competing risks and the Kaplan-Meier methods were used to estimate outcomes at 3 years and 5 years. RESULTSIn all, 550 patients (mean [SD] age, 64 [10.4] years; men, 465 [85%]) met inclusion criteria. Pharyngocutaneous fistula occurred in 127 patients (23%). The difference in locoregional control between the group of patients with PCF (75%) and the non-PCF (72%) group was 3% (95% CI, −6% to 12%). The difference in overall survival between the group with PCF (44%) and the non-PCF group (52%) was 8% (95% CI, −2% to 20%). The difference in disease-free survival between PCF and non-PCF groups was 6% (95% CI, −4% to 16%). In the multivariable model, patients with PCF were at a 2-fold higher rate of distant metastases (hazard ratio, 2.00; 95% CI, 1.22 to 3.27). Distant control was reduced in those with PCF, a 13% (95% CI, 3% to 21%) difference in 5-year distant control.CONCLUSIONS AND RELEVANCE This multicenter retrospective cohort study found that development of PCF after salvage laryngectomy is associated with an increased risk for the development of distant metastases.

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Section: Discussionmentioning

confidence: 99%

Association of Pharyngocutaneous Fistula With Cancer Outcomes in Patients After Laryngectomy

Davies

Hugh

Rich

et al. 2021

JAMA Otolaryngol Head Neck Surg

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“…Apart from the inflammation marker, NLR is used as a prognostic factor in cancers. Higher pretreatment NLR is correlated with worse OS in oropharyngeal cancer treated and worse disease-free survival and OS in esophageal cancer with radiotherapy [ 47 , 48 , 49 ]. High post-RT NLR is associated with poor OS and PFS in nasopharyngeal cancer and higher recurrent rate in breast cancer [ 39 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy

Homkham

Muangwong

Pisprasert

et al. 2021

CBM

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BACKGROUND: Immune-enhancing nutrition (IMN) strengthens the systematic inflammatory response and the immune system. Neutrophil to lymphocyte ratio (NLR) and absolute lymphocyte count (ALC) are affected during cancer therapies. OBJECTIVE: We carried out an analysis of the dynamic changes in NLR and ALC over time in cancer patients with or without IMN supplementation. METHODS: 88 cancer patients receiving concurrent chemoradiotherapy (CCRT) were randomized into regular diet group, and regular diet and IMN group.Generalized estimation equation models were used to assess associations between patient’s characteristics, IMN, and dynamic changes in NLR and ALC over time. RESULTS: NLR and ALC at preCCRT were significantly associated with dynamic changes in NLR (adjusted β= 1.08, 95% confidence interval [CI]: 0.64–1.52) and ALC (adjusted β= 0.41, 95% CI: 0.36–0.46). The magnitudes of the NLR and ALC changes through CCRT were lower in patients receiving IMN, although the differences were not statistically significant except ALC at the end of CCRT in head and neck cancer patients (P= 0.023). CONCLUSION: Dynamic negative changes in both markers were demonstrated throughout CCRT. There were non-significant trend in promising changes in both NLR and ALC values in the whole group in IMN supplementation.

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“…However, the mechanism by which a low PNI decreases the survival time of patients with BC has not been fully elucidated. The PNI is based on lymphocyte count and albumin level, which are significantly closely related to the prognosis of cancer patients [ 30 ], and a low PNI indicates increased inflammatory reaction and poor nutritional status [ 31 ]. Prior study reported that BC patients with higher serum albumin showed 45% reduced risk of death (HR = 0.55, 95% CI: 0.40–0.75) than those with lower albumin level, indicating that albumin could be an independent predictor of prognosis of BC patients [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of prognostic nutritional index and systemic immune‐inflammation index in patients after curative breast cancer resection: a retrospective cohort study

Zhang

et al. 2022

BMC Cancer

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Background Nutritional status and inflammation are closely associated with poor outcome in malignant tumors. However, the prognostic impact of postoperative in these variables on breast cancer (BC) remains inconclusive. We aimed to determine whether prognostic nutritional index (PNI), systemic immune‐inflammation index (SII), neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) affect two long-term outcomes among patients after curative resection of BC. Methods We retrospectively reviewed 508 patients with BC treated with curative surgery between February 5, 2013 and May 26, 2020. All patients were divided into 3 groups based on tertiles (T1-T3) of PNI, SII, NLR, and PLR. The effects of four indexes on disease-free survival (DFS) and overall survival (OS) have been evaluated using Cox proportional hazards models and Kaplan–Meier method. Results Compared with PNI-lowest cases, patients with highest PNI showed significantly longer DFS (multivariate adjusted hazard ratio [HR] = 0.37, 95% confident interval [CI] 0.19–0.70, P for trend = 0.002), whereas higher PLR seemed to be marginally associated with poorer DFS (P for trend = 0.086 and 0.074, respectively). Subgroup analyses indicate the potential modification effects of family history of BC and radiotherapy on the prognosis value of PNI to DFS in BC patients (P for interaction = 0.004 and 0.025, respectively). In addition, the levels of three inflammatory indices, namely SII, NLR, and PLR might be positively related with increased age at diagnosis (all P for trend < 0.001). Conclusions A high PNI was associated with better DFS, supporting its roles as prognostic parameters for patients with BC. The nutritional status and systemic immune may exert great effects on patient prognosis. Further studies are warrant to explore the prognosis value of PLR.

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Prognostic significance of serum inflammatory markers in esophageal cancer

Cited by 16 publications

References 37 publications

Association of Pharyngocutaneous Fistula With Cancer Outcomes in Patients After Laryngectomy

Association of Pharyngocutaneous Fistula With Cancer Outcomes in Patients After Laryngectomy

Dynamic changes in practical inflammation and immunity markers in cancer patients receiving immune-enhancing nutritional supplementation during concurrent chemoradiotherapy

Prognostic significance of prognostic nutritional index and systemic immune‐inflammation index in patients after curative breast cancer resection: a retrospective cohort study

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