Prognostic significance of selected immunological and biochemical parameters in the cerebrospinal fluid of Ossimi sheep with encephalitic listeriosis

Tumor Necrosis Factor-α, Interleukins-12(p40), 6, and 10 levels in cerebrospinal fluid and outcome prediction in Ossimi sheep with encephalitic listeriosis

“…This result is in agreement with that in previous reports [15,16,21]. Generally, clinical signs of listeriosis vary in severity depending upon the degree and precise location of the abscesses [22].…”

“…Little information about the cytokine response and its prognostic value in sheep with encephalitic listeriosis is available. A study has been conducted to assess the prognostic value of Interleukin-1b in CSF in sheep with encephalitic listeriosis [15]. Consequently, assessment of prognostic value of CSF cytokine was the objective.…”

“…IL-6 has been also found associated with a variety of septic insults [13,26,39], and spinal cord injury [40]. On the contrary, in sheep with encephalitic listeriosis, IL-1b in CSF had prognostic value [15]. Moreover, CSF levels of IL-1b and IL-18 were related to complications, and unfavorable outcome of pneumococcal meningitis [41].…”

“…However, in sheep, one report have been assessed the role of selected CSF biochemical and immunological parameters for their prognostic value [15]. Therefore, the objective of the present study was to evaluate the prognostic significance of CSF cytokines, TNF-a, Interleukin-6, Interleukin-10 and Interleukin-12 (p40) in Ossimi sheep with encephalitic Listeriosis.…”

Differential diagnosis of neurological diseases of small ruminants

“…Η διάγνωση της νευρικής μορφής της λιστερίω-σης βασίζεται στην εξέταση δείγματος εγκεφαλονω-τιαίου υγρού, κατά την οποία παρατηρείται αύξηση της συγκέντρωσης πρωτεϊνών και πλειοκυττάρωση (Scott 2010a, El-Boshy et al 2012. Μπορούν επίσης να χρησιμεύσουν διάφορες ανοσολογικές μέθοδοι (π.χ., ELISA, σύνδεση συμπληρώματος) για ανί-χνευση αντισωμάτων έναντι του μικροοργανισμού ή του κύριου λοιμογόνου χαρακτηριστικού αυτού, της λιστεριολυσίνης Ο, αν και, συχνά, τα αποτελέσμα-τα αυτών δεν είναι αξιόπιστα (Low and Donachie 1997).…”