Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia

Haus, Olga; Noworolska, A; Laskowski, Michał; Kuliszkiewicz‐Janus, Małgorzata; Kozłowska, Joanna; Harłozińska-Szmyrka, A; Jagielski, J; Kotlarek-Haus, S

doi:10.1016/0014-4800(90)90008-2

Cited by 4 publications

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“…As mentioned above, occasional case reports of CML with 11q23 translocations are available in the literature. The fusion partners previously reported for 11q23 in CML include 1q21 [ 10 ], 2p21 [ 12 ], 4q21 [ 5 ], 6q25 [ 7 ], 9p22 [ 11 , 8 , 6 ], 17q21 [ 9 ], 19p13.1 [ 14 ], and 19p13.3 [ 13 ]. In our study, 9p21-22/AF9 was the most common partner for 11q23.…”

Section: Discussionmentioning

confidence: 99%

Chromosomal rearrangement involving 11q23 locus in chronic myelogenous leukemia: a rare phenomenon frequently associated with disease progression and poor prognosis

et al. 2015

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BackgroundProgression of chronic myelogenous leukemia (CML) is frequently accompanied by cytogenetic evolution, commonly unbalanced chromosomal changes, such as an extra copy of Philadelphia chromosome (Ph), +8, and i(17)(q10). Balanced chromosomal translocations typically found in de novo acute myeloid leukemia occur occasionally in CML, such as inv(3)/t(3;3), t(8;21), t(15;17), and inv(16). Translocations involving the 11q23, a relatively common genetic abnormality in acute leukemia, have been seldom reported in CML. In this study, we explored the prevalence and prognostic role of 11q23 in CML.MethodsWe searched our pathology archives for CML cases diagnosed in our institution from 1998 to present. Cases with 11q23 rearrangements were retrieved. The corresponding clinicopathological data were reviewed.ResultsA total of 2,012 cases of CML with available karyotypes were identified. Ten (0.5%) CML cases had 11q23 rearrangement in Ph-positive cells, including 4 cases of t(9;11), 2 cases of t(11;19), and 1 case each of t(2;11), t(4;11), t(6;11), and t(4;9;11). Eight cases (80%) had other concurrent chromosomal abnormalities. There were 6 men and 4 women with a median age of 50 years (range, 21–70 years) at time of initial diagnosis of CML. 11q23 rearrangement occurred after a median period of 12.5 months (range, 0–172 months): 1 patient in chronic phase, 2 in accelerated phase, and 7 in blast phase. Eight of ten patients died after a median follow-up of 16.5 months (range, 8–186 months) following the initial diagnosis of CML, and a median of 6.7 months (range, 0.8–16.6 months) after the emergence of 11q23 rearrangement. The remaining two patients had complete remission at the last follow-up, 50.2 and 6.9 months, respectively. In addition, we also identified a case with 11q23/t(11;17) in Ph-negative cells in a patient with a history of CML. MLL involvement was tested by fluorescence in situ hybridization in 10 cases, and 7 cases (70%) were positive.ConclusionsIn summary, chromosomal rearrangements involving 11q23 are rare in CML, frequently occurring in blast phase, and are often associated with other cytogenetic abnormalities. These patients had a low response rate to tyrosine kinase inhibitors and a poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Chromosomal rearrangement involving 11q23 locus in chronic myelogenous leukemia: a rare phenomenon frequently associated with disease progression and poor prognosis

et al. 2015

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“…Aberrations reduce the survival time of these patients (23,24) (B). The presence of additional chromosomal aberrations increases mortality by 36% (NNH: 3) and reduces the mean overall survival of CML patients submitted to stem cell transplantation (25) (B).…”

Section: Do Cytogenetic Abnormalities In Addition To the Philadelphiamentioning

confidence: 99%

Chronic myeloid leukemia treatment guidelines: Brazilian Association of Hematology, Hemotherapy and Cell Therapy. Brazilian Medical Association Guidelines Project - 2012

Souza¹,

Pagnano²,

Bendit³

et al. 2012

Revista Brasileira De Hematologia E Hemoterapia

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Cytogenetics and Clonal Evolution in Childhood Acute Lymphoblastic Leukemia (ALL)

Harbott¹,

Reinisch-Becker²,

Ritterbach³

et al. 1996

Acute Leukemias V

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Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia

Cited by 4 publications

References 14 publications

Chromosomal rearrangement involving 11q23 locus in chronic myelogenous leukemia: a rare phenomenon frequently associated with disease progression and poor prognosis

Chromosomal rearrangement involving 11q23 locus in chronic myelogenous leukemia: a rare phenomenon frequently associated with disease progression and poor prognosis

Chronic myeloid leukemia treatment guidelines: Brazilian Association of Hematology, Hemotherapy and Cell Therapy. Brazilian Medical Association Guidelines Project - 2012

Cytogenetics and Clonal Evolution in Childhood Acute Lymphoblastic Leukemia (ALL)

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