Prognostic significance of <scp>CD</scp>20 expression and <scp>E</scp>pstein‐<scp>B</scp>arr virus (<scp>EBV</scp>) association in classical <scp>H</scp>odgkin lymphoma in <scp>J</scp>apan: A clinicopathologic study

Elsayed, Ahmed Ali; Asano, Naoki; Ohshima, Koichi; Izutsu, Koji; Kinoshita, Tomohiro; Nakamura, Shigeo

doi:10.1111/pin.12175

Cited by 18 publications

(13 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In CHL, there are several poor prognostic factors, including CTM expression, 8 EBV infection, 9 and marked infiltration of CD68-positive macrophages, 10 which were all observed in the current case. In addition, the reasons for the fulminant clinical course in the current case were likely associated with the severe angiodestruction revealed by autopsy.…”

Section: Discussionsupporting

confidence: 60%

A fulminant case of classical Hodgkin lymphoma: A diagnostic dilemma of Epstein‐Barr virus‐positive large B‐cell neoplasms

Ichimata

Kobayashi

Ohya

et al. 2019

Pathology International

View full text Add to dashboard Cite

We report a fulminant case of classical Hodgkin lymphoma (CHL). The patient died only approximately 2 months after the onset of subjective symptoms. Autopsy specimens revealed atypical cells resembling Hodgkin and Reed‐Sternberg (HRS) cells in a rich inflammatory background in various organs. There were marked, characteristic angiodestructive lesions from infiltrating HRS‐like cells and numerous macrophages. The HRS‐like cells were infected with Epstein‐Barr virus (EBV), immunohistochemically positive for PAX5 and CD30, and negative for CD3, CD20, and ALK. Most B‐cell markers other than PAX5 were negative, and the HRS‐like cells also expressed cytotoxic molecules. Monoclonal rearrangement of immunoglobulin heavy chain was detected by PCR analysis. According to the 2016 WHO classification, we diagnosed mixed cellularity CHL. However, EBV‐positive diffuse large B‐cell lymphoma (DLBCL), not otherwise specified and EBV‐positive B‐cell lymphoma, unclassifiable with features intermediate between DLBCL and CHL were considered as differential diagnoses because both tumors are aggressive EBV‐positive large B‐cell neoplasms with reactive inflammatory cells and sometimes contains HRS‐like cells. The clinical condition of the current case was closer to these two entities than to CHL. A diagnosis of EBV‐positive large B‐cell neoplasms was difficult because of overlapping morphological and immunohistochemical characteristics, but should be considered for prognosis.

show abstract

Section: Discussionsupporting

confidence: 60%

A fulminant case of classical Hodgkin lymphoma: A diagnostic dilemma of Epstein‐Barr virus‐positive large B‐cell neoplasms

Ichimata

Kobayashi

Ohya

et al. 2019

Pathology International

View full text Add to dashboard Cite

show abstract

“…In addition, older patients were reported to have a higher proportion of CD20-positivity than younger patients. 18 , 26 - 29 As our study found no significant correlation between CD79a and CD20 expression, they may be independent B-cell markers in CHL. Indeed, CD20- and CD79a-positivity were reported to be only weakly correlated.…”

Section: Discussioncontrasting

confidence: 50%

“…In contrast to CD79a, the prognostic impact of CD20 has been well documented, although controversies remain. 26 , 28 , 29 …”

Section: Discussionmentioning

confidence: 99%

Clinicopathological significance of CD79a expression in classic Hodgkin lymphoma

Sakatani

Igawa

Okatani

et al. 2020

JCEH

View full text Add to dashboard Cite

Classic Hodgkin lymphoma (CHL) is a lymphoid neoplasia characterized by the presence of large tumor cells, referred to as Hodgkin and Reed-Sternberg (HRS) cells, originating from B-cells in an inflammatory background. As the clinical significance of B-cell markers has yet to be fully elucidated, this study aimed to clarify the clinicopathological significance of CD79a in 55 patients with CHL. They were immunohistochemically divided into two groups, comprising of 20 CD79a-positive and 35 CD79a-negative patients. There was no significant correlation between CD79a and CD20 expression ( r s = 0.125, P = 0.362). CD79a-positive patients were significantly older at onset ( P = 0.011). There was no significant correlation between CD79a-positivity and clinical stage ( P = 0.203), mediastinal involvement ( P = 0.399), extranodal involvement ( P = 0.749), or laboratory findings, including serum levels of lactate dehydrogenase ( P = 1) and soluble interleukin-2 receptor ( P = 0.251). There were significant differences in overall survival (OS) ( P = 0.005) and progression-free survival (PFS) ( P = 0.007) between CD79a-positive and CD79a-negative patients (5-year OS: 64.6% and 90.5%; 5-year PFS: 44.0% and 76.6%, respectively). Five patients in whom the majority (> 80%) of HRS cells expressed CD79a consisted of 4 males and 1 female aged between 52 and 81 years; 4 of them were in a limited clinical stage. We concluded that CD79a-positive CHL may have unique clinicopathological features.

show abstract

“…In fact, the prognostic relevance of BCA, p53, and Bcl2 in cHL is highly controversial. Literature data on BCA are focused mainly on CD20 and correlate its expression to either worse, 40 neutral, 41,42 or better 43 survival rates compared with controls. The same holds true for Bcl2 and p53, which have been variably associated with prognosis 10,20,43‐49 .…”

Section: Discussionmentioning

confidence: 99%

Histology of pediatric classic Hodgkin lymphoma: From diagnosis to prognostic stratification

Pizzi

Tazzoli

Carraro

et al. 2020

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Aims Classic Hodgkin lymphoma (cHL) is a common malignancy of the pediatric age. Although clinical‐radiological features are routinely used for disease risk stratification, the role of tumor histology has yet to be defined. This study aimed to characterize the clinical‐pathological features of a large cohort of pediatric cHL specifically investigating the relevance of tumor histology for the prognostic stratification of patients. Methods and results The study considered 96 clinically annotated cases of pediatric cHL treated according to the AIEOP‐LH2004 protocol. The following histological parameters were considered: (i) cHL variant; (ii) grade of nodular sclerosis (NS); (iii) staining for Bcl2 and p53, and expression of B‐cell (BCA) and T‐cell antigens (TCA) by Hodgkin/Reed‐Sternberg cells. The study population consisted of 51 males and 45 females (median age: 13.6 years) with five‐year overall and progression‐free survival of 94% and 81%, respectively. Most cases featured NS morphology (96%) with a prevalence of NS1 over NS2 grades. Two NS2 variants were recognized (sarcomatous/syncytial and fibrohistiocytic). A consistent subset of cases disclosed positivity for BCA (34%), TCA (26%), p53 (13%), and Bcl2 (19%). Clinical‐pathological correlations showed a more aggressive clinical course for NS2 over NS1 cases. The NS2 fibrohistiocytic variant was associated with the worst outcome. No other histological features correlated with prognosis. Conclusions Pediatric cHL is a clinically and histologically heterogeneous neoplasm. The majority of cases disclose NS morphology and aberrant phenotypes are frequently encountered. In the pediatric population, NS grading and NS2 subtyping bear significant prognostic impact.

show abstract

Prognostic significance of CD20 expression and Epstein‐Barr virus (EBV) association in classical Hodgkin lymphoma in Japan: A clinicopathologic study

Cited by 18 publications

References 45 publications

A fulminant case of classical Hodgkin lymphoma: A diagnostic dilemma of Epstein‐Barr virus‐positive large B‐cell neoplasms

A fulminant case of classical Hodgkin lymphoma: A diagnostic dilemma of Epstein‐Barr virus‐positive large B‐cell neoplasms

Clinicopathological significance of CD79a expression in classic Hodgkin lymphoma

Histology of pediatric classic Hodgkin lymphoma: From diagnosis to prognostic stratification

Contact Info

Product

Resources

About