Prognostic significance of regional lymph node metastasis according to station in ampullary carcinoma

Tashiro, Keita; Kuroki, Naomi; Einama, Takahiro; Iwasaki, Tetsushi; Miyata, Yuhei; Aosasa, Suefumi; Inoue, Yosuke; Takahashi, Yu; Ogata, Sho; Ueno, Hideki; Hase, Kazuo; Yamamoto, Junji; Kishi, Yoji

doi:10.1002/jhbp.791

Cited by 8 publications

(8 citation statements)

References 29 publications

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“…In previous studies, several predictors of LNM in resected AVC have been described including number of retrieved LNs, ratio of positive LNs/retrieved LNs, number of metastatic LNs (based on UICC N stage classi cation), and location of regional LNs (pancreatic head or except for pancreas head) [5,6,[18][19][20]. Matui et al reported that regional LNM, except to the pancreatic head region, was associated with poor prognosis, comparable to that of patients with M1-stage [21].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Importance of lymph node metastasis to the pancreatic head region in patients with ampulla of Vater carcinoma

Tabuchi

Kimura

Sui

et al. 2022

Preprint

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Background: We analyzed clinicopathologic variables and postoperative outcomes in patients with ampulla of Vater carcinoma (AVC) to identify key predictors of post-resection prognosis.Methods: Fifty-five patients who underwent pancreaticoduodenectomy for AVC with curative intent between 2005 and 2020 were included in this study. A retrospective review of the clinical records of patients who underwent surgical exploration for AVC was performed using univariate and multivariate analyses. Clinical and pathological factors that influenced patient survival were analyzed. Results: One-, 3-, and 5-year overall survival rates after surgery were 97.4%, 71.8%, and 63.0%, respectively. A total of 21 patients developed recurrent disease after curative resection for AVC. The most frequently observed sites of recurrence were lymph nodes in 11 patients (52%), followed by the liver in 8 (38%), lung in 6 (29%), local in 3 (14%), and peritoneal dissemination in 3 (14%). Estimated 3- and 5-year recurrence free survival rates for the entire cohort were 62.8% and 57.2%, respectively. On multivariate analysis, only the presence of lymph node metastasis extending to the pancreatic head region (hazard ratio = 5.374; 95% confidence interval: 1.279–22.58; P = 0.022) predicted inferior relapse-free survival. A significant correlation between postoperative recurrence and pathological lymph node metastasis was observed. Conclusions: Lymph node metastasis, especially that which extends to the pancreatic head region, was clearly identified as a prognostic indicator of reduced relapse-free survival in patients who have undergone curative surgical treatment for AVC.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Importance of lymph node metastasis to the pancreatic head region in patients with ampulla of Vater carcinoma

Tabuchi

Kimura

Sui

et al. 2022

Preprint

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“…The clinical features of the patients are shown in Table I. Patients with head and neck cancer were divided into four stages, according to tumor-node-metastasis (TNM) ( 17 ) and differences in TMEM158 expression at different Tumor-Node-Metastasis stages were analyzed. RNAInter software ( ; Department of Bioinformatics, Southern Medical University) was used to predict the target association between miR-548ac and TMEM158.…”

Section: Methodsmentioning

confidence: 99%

MicroRNA‑548ac induces apoptosis in laryngeal squamous cell carcinoma cells by targeting transmembrane protein 158

Song¹,

Yang²,

Liu³

2020

Oncol Lett

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Laryngeal cancer is a common head and neck cancer that effects the quality of life of those affected. Early diagnosis and treatment are vital to minimize the harmful effects of laryngeal cancer, which can improve the survival rate of patients following surgery and retain the voice function of the larynx. The purpose of the present study was to explore the molecular mechanism of the development of laryngeal cancer and to determine the biomarker for the diagnosis and treatment of laryngeal cancer. Reverse transcription-quantitative PCR (RT-qPCR) and The Cancer Genome Atlas database analysis were used to confirm high expression of TMEM158 in laryngeal cancer. The effects of TMEM158 and miR-548ac was investigated through in vitro and in vivo assays (MTT assay, colony-formation assay, flow cytometry assay, western blotting and tumor xenograft assay). Luciferase reporter assay, western blotting and RTq-PCR were used to confirm that miR-548 directly targeted the 3'-untranslated region of TMEM158 and inhibited TMEM158 expression. Taken together, the present results suggest that miR-548ac functions as a crucial cancer suppressor in laryngeal cancer, which induces apoptosis in laryngeal cancer cells by suppressing TMEM158. Thus, miR-548ac may be a potential target for the treatment of laryngeal cancer. Materials and methods Cell lines and culture. Human LSC-1 cells and NP69 nasopharyngeal epithelial cells were purchased from the Institute

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“…This facilitates complete dissection of station 17 nodes, which are the first group of involved lymph nodes in periampullary and pancreatic cancer. [ 3 ] Once the mesenteric division reaches the first jejunal vein, further dissection is done along the wall of the first jejunal vein. PIPDV joining the first jejunal vein close to its confluence with SMV is ligated and divided [ Figure 6 ].…”

Section: Operative Stepsmentioning

confidence: 99%

The technique of precise and systematic vascular control during robotic pancreaticoduodenectomy for periampullary and pancreatic tumours

Kalayarasan

Gautham

Gnanasekaran

et al. 2021

Journal of Minimal Access Surgery

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Robotic pancreaticoduodenectomy (PD) remains one of the most advanced robotic procedures. Improved ergonomics and stable 3D vision with robotic platform helped overcome the technical challenges of pancreatic reconstruction in minimally invasive PD. However, inadequate understanding of the complex vascular anatomy of the pancreatic head and uncinate process often results in intra-operative bleeding and prolongs the learning curve. The technique of precise identification and systematic control of the vessels supplying the head and the uncinate process is described in this report. A good understanding of the common vascular anatomy and variations along with stepwise precise vascular control described in this report could minimise intra-operative bleeding and shorten the learning curve associated with robotic PD.

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Prognostic significance of regional lymph node metastasis according to station in ampullary carcinoma

Cited by 8 publications

References 29 publications

WITHDRAWN: Importance of lymph node metastasis to the pancreatic head region in patients with ampulla of Vater carcinoma

WITHDRAWN: Importance of lymph node metastasis to the pancreatic head region in patients with ampulla of Vater carcinoma

MicroRNA‑548ac induces apoptosis in laryngeal squamous cell carcinoma cells by targeting transmembrane protein 158

The technique of precise and systematic vascular control during robotic pancreaticoduodenectomy for periampullary and pancreatic tumours

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