Prognostic significance of red cell distribution width in bladder cancer

Ma, Wenchao; Mao, Shun; Bao, Meiyu; Wu, Yuan; Guo, Yadong; Wang, Ruiliang; Cheng, Li; Zhang, Junfeng; Zhang, Wentao; Yao, Xudong

doi:10.21037/tau.2020.03.08

Cited by 15 publications

(13 citation statements)

References 36 publications

(32 reference statements)

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“…RDW level may change as a result of blood diseases, infectious diseases, malnutrition, and even germline mutations associated with CRC (20)(21)(22). Additionally, studies have revealed that elevated RDW level was an independent risk factor for unfavorable survival in patients with CRC and bladder cancer (13)(14)(15). Consistent with the previous studies, the results of this study revealed that preoperative elevated RDW-SD level was an unfavorable predictor of PFS and elevated RDW-CV level was related to postoperative complications in patients with CRLM.…”

Section: Nomogram For Os Predictionsupporting

confidence: 90%

“…(9)(10)(11)(12). It has been reported that the red cell volume distribution width (RDW) level of patients with malignant tumours including rectal cancer, colon cancer and bladder cancer is correlated with diagnosis, staging, and prognosis (13)(14)(15). However, no study has revealed the relationship between RDW level and prognosis in patients with CRLM after liver resection, and no nomogram has incorporated preoperative blood markers.…”

Section: Introductionmentioning

confidence: 99%

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Nomograms incorporating preoperative RDW level for the prediction of postoperative complications and survival in colorectal liver metastases after resection

et al. 2021

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Background: This study aimed to investigate the predictive significance of preoperative red cell volume distribution width (RDW) level for prognosis and to establish nomograms incorporating preoperative blood markers to predict postoperative complications and survival in patients with colorectal liver metastases (CRLM).Methods: This retrospective study included 380 enrolled CRLM patients who underwent hepatic resection.Predictors of postoperative complications were explored using binary logistic regression analysis. Covariates associated with overall survival (OS) and progression-free survival (PFS) were evaluated through univariate and multivariate Cox regression analyses. Only variables that reached statistical significance at P<0.1 in the univariate analysis were allowed to enter the multivariate analyses. The independent predictors that retained in the final multivariate model were incorporated into nomograms. Results:The optimal cut-off point of preoperative RDW-CV was 16%, and elevated RDW-CV was significantly associated with better prognosis (mPFS: 5.0 vs. 8.9 months, P=0.007; mOS: 59.0 vs. 42.0 months, P=0.041). The optimal cut-off point of preoperative RDW-SD was 43.9 fl, and elevated RDW-SD was significantly associated with worse prognosis (mPFS: 8.0 vs. 13.0 months, P<0.001; mOS:36.8 vs. 70.2 months, P=0.001). A nomogram predicting postoperative complications was constructed based on preoperative gamma-glutamyl transpeptidase (GGT) ≥34.5 U/L, preoperative RDW-CV ≥14.1%, and intraoperative blood loss ≥200.0 mL, with AUROC of 0.658. The calibration curves and Hosmer-Lemeshow test revealed desirable model calibration (chi-square: 3.99, P=0.91). A nomogram predicting PFS was constructed based on preoperative GGT ≥31.0 U/L, preoperative D-dimer ≥0.251 mg/L, preoperative RDW-CV <16.0%, preoperative RDW-SD ≥43.9 fl, positive lymph node metastasis, bilobar liver distribution, and R0 resection with good discrimination (C-index: 0.676±0.016) and calibration. A nomogram for the prediction of OS was constructed with favorable discrimination (C-index: 0.700±0.021) and calibration. Significant differences in PFS and OS were shown among patients stratified into three different risk groups (P<0.001) based on the nomograms. Conclusions: This study first revealed the relationship between preoperative RDW-SD, RDW-CV, and prognosis in patients with CRLM. It also established nomograms especially considering preoperative blood markers to predict postoperative complications, PFS, and OS, which facilitated physicians to determine the optimal clinical management strategies.

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Section: Nomogram For Os Predictionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Nomograms incorporating preoperative RDW level for the prediction of postoperative complications and survival in colorectal liver metastases after resection

et al. 2021

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“…Traditionally, this parameter was used for the differential diagnosis of anemias. 16 Felker et al found that RDW could serve as an independent predictor of morbidity and mortality in heart failure. 31 Furthermore, many authors have described the link between high RDW and worse prognosis in different types of malignancies such as lung cancer and prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Red blood cell distribution width (RDW) is a parameter that reproduces the volume heterogeneity of RBCs, and it can be obtained from the standard deviation (SD) of erythrocyte volumes for the mean corpuscular volume (MCV) 16 . High RDW values reveal greater size variations of red blood cells, which were reported to be associated with multiple interconnected factors, such as chronic inflammation, prolonged bleeding, or oxidative stress 17 .…”

Section: Introductionmentioning

confidence: 99%

Baseline neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) correlate with advanced stages in cutaneous squamous cell carcinoma

Raimondo

Caposiena

Spallone³

et al. 2021

Int J Dermatology

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Background The neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) at diagnosis have been shown to correlate with advanced disease and to be prognostic factors in many tumors. However, their role as a prognostic factor for cutaneous squamous cell carcinoma (cSCC) has not yet been studied.Objective Therefore, the aim of our study was to evaluate the correlation of NLR and RDW with stages of disease in patients with cSCC in order to define whether or not higher values of these two markers correlate with a more aggressive disease.Methods We retrospectively analyzed the NLR and RDW in a total of 51 newly diagnosed cSCC patients. NLR and RDW were calculated using data obtained from the complete blood count (CBC). ResultsMedian NLR among patients with the non-advanced disease (in situ and stage I) was 2.2, whereas median NLR for patients with advanced disease was 4.87. Median RDW among patients with early stage disease was 13.7%, while median RDW in patients with advanced disease was 15.81%. Statistical analysis showed positive associations of advanced cSCC stages with NLR or RDW higher than 3.07 or 14.5%, respectively.Conclusions Therefore, our analysis demonstrated how both NLR and RDW represent cheap and easily available factors that could be used as markers for advanced cSCC.They could help to identify patients with advanced stages disease that requires a strict follow-up.

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“…Then 73 articles were reviewed in full text to carefully assess the eligibility, 60 of them were further excluded (reasons for exclusion are: other types of urological cancer patients mingled with bladder cancer patients, did not provide measurements of CRP, did not investigate the outcomes of study interest, case-control or cross-sectional design studies, did not use Cox proportional hazards model). In the end, 13 studies were included into our meta-analysis [12][13][14][15][18][19][20][21][22][23][24][25][26].…”

Section: Study Selectionmentioning

confidence: 99%

C-reactive protein with the survival outcomes of bladder cancer patients: a meta-analysis

Donald¹,

Ran²,

Fang³

et al. 2020

Preprint

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Objectives Accumulating evidences suggested that serum C-reactive protein (CRP) was associated with the survival of bladder cancer patients. However, incongruent findings have been reported. Methods We comprehensively searched PubMed, Embase, and Web of science through August 2020 in order to find all eligible studies on the association between CRP and the overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS) of bladder cancer patients. The pooled hazard ratios (HRs) together with their 95% confidence intervals (CIs) were estimated by fixed-effect model if the heterogeneity was low, and random-effect model if the heterogeneity was high. A series of subgroup meta-analysis were performed with regard to the specific characteristics of study design. Results Thirteen eligible studies were included in this meta-analysis. The pooled results of 8 included studies revealed that an elevated CRP was associated with poor OS (HR = 2.24, 95% CI: 1.16–4.34) and CSS (HR = 1.53 95% CI: 1.36–1.72) of bladder cancer. Besides, the combined results of 3 included studies also indicated an inferior DFS for bladder cancer patients of elevated CRP level (HR = 2.07, 95% CI: 1.24–3.35). Subgroup analyses supported the robust association between elevated CRP and CSS. Conclusions These findings suggested that bladder cancer patients reported increase serum CRP had inferior prognostic outcomes.

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Prognostic significance of red cell distribution width in bladder cancer

Cited by 15 publications

References 36 publications

Nomograms incorporating preoperative RDW level for the prediction of postoperative complications and survival in colorectal liver metastases after resection

Nomograms incorporating preoperative RDW level for the prediction of postoperative complications and survival in colorectal liver metastases after resection

Baseline neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width (RDW) correlate with advanced stages in cutaneous squamous cell carcinoma

C-reactive protein with the survival outcomes of bladder cancer patients: a meta-analysis

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