Prognostic significance of psychosocial factors in African‐American and white breast cancer patients

Soler-Vilá, Hosanna; Kasl, Stanislav V.; Jones, Michelle L.

doi:10.1002/cncr.11670

Cited by 84 publications

(71 citation statements)

References 76 publications

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“…The implications of such effects for immunologic effector functions or disease pathophysiology remain unclear because SEBAS lacks direct measures of those processes. However, the pattern of decreasing leukocyte functional sensitivity to HPA regulation with increasing levels of subjective social isolation is consistent with the profile of increased inflammatory disease risk observed in human epidemiologic studies (Berkman 1977;House, Landis et al 1988;Reynolds and Kaplan 1990;Krongrad, Lai et al 1996;Seeman 1996;Cohen, Doyle et al 1997;Berkman and Kawachi 2000;Cacioppo and Hawkley 2003;Cole, Kemeny et al 2003;Soler-Villa, Kasl et al 2003;Caspi, Harrington et al 2006;Kroenke, Kubzansky et al 2006) and in animal models (Sklar and Anisman 1980;Ben-Nathan, Lustig et al 1989;Shively, Clarkson et al 1989;Clausing, Bocker et al 1994;Hilakivi-Clarke and Dickson 1995;Villano Bonamin, Barbuto et al 2001;Wu, Murata et al 2001;McClintock, Conzen et al 2005;Hermes, Rosenthal et al 2006;Thaker, Han et al 2006). A significant challenge for future research lies in understanding the teleologic basis for these relationships.…”

Section: Discussionsupporting

confidence: 62%

“…Social isolation is a risk factor for several adverse health outcomes including all-cause mortality (Berkman 1977;House, Landis et al 1988;Seeman 1996;Berkman and Kawachi 2000;Cacioppo and Hawkley 2003), and specific infectious, neoplastic, and cardiovascular diseases (Reynolds and Kaplan 1990;Krongrad, Lai et al 1996;Cohen, Doyle et al 1997;Eng, Rimm et al 2002;Cole, Kemeny et al 2003;Soler-Villa, Kasl et al 2003;Caspi, Harrington et al 2006;Kroenke, Kubzansky et al 2006). A recent functional genomics analysis suggests that alterations in immune system regulation by the hypothalamicpituitary-adrenal (HPA) axis might contribute to these effects (Cole, Hawkley et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity

Cole

2008

Brain, Behavior, and Immunity

138

115

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Recent small-scale genomics analyses suggest that physiologic regulation of pro-inflammatory gene expression by endogenous glucocorticoids may be compromised in individuals who experience chronic social isolation. This could potentially contribute to the elevated prevalence of inflammation-related disease previously observed in social isolates. The present study assessed the relationship between leukocyte distributional sensitivity to glucocorticoid regulation and subjective social isolation in a large population-based sample of older adults. Initial analyses confirmed that circulating neutrophil percentages were elevated, and circulating lymphocyte and monocyte percentages were suppressed, in direct proportion to circulating cortisol levels. However, leukocyte distributional sensitivity to endogenous glucocorticoids was abrogated in individuals reporting either occasional or frequent experiences of subjective social isolation. This finding held in both nonparametric univariate analyses and in multivariate linear models controlling for a variety of biological, social, behavioral, and psychological confounders. The present results suggest that social factors may alter immune cell sensitivity to physiologic regulation by the hypothalamic-pituitary-adrenal axis in ways that could ultimately contribute to the increased physical health risks associated with social isolation.

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Section: Discussionsupporting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity

Cole

2008

Brain, Behavior, and Immunity

138

115

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“…These employment benefits have been shown to be better among whites compared to other race and ethnic groups [36,37]. Despite a greater proportion of diagnoses at a later stage of cancer [38], of elsevier_AEP_7850 black and Hispanic cancer survivors are as likely to remain in the workforce as their counterparts with no cancer diagnosis despite their reports of poorer health compared to whites.…”

Section: Discussionmentioning

confidence: 99%

Working with cancer: health and employment among cancer survivors

Clarke

Christ

Soler-Vilá

et al. 2015

Annals of Epidemiology

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. Abstract PurposeCancer affects a growing proportion of US workers. Factors contributing to whether they continue or return to work after cancer diagnosis include: age, physical and mental health, health insurance, education, and cancer site.The purpose of this study was to assess the complex relationships between health indicators and employment status for adult cancer survivors. MethodsWe analyzed pooled data from the 1997-2012 US National Health Interview Survey (NHIS). Our sample included adults with a self-reported physician diagnosis of cancer (n = 24,810) and adults with no cancer history (n = 382,837). Using structural equation modeling (SEM), we evaluated the relationship between sociodemographic factors, cancer site, and physical and mental health indicators on the overall health and employment status among adults with a cancer history. ResultsThe overall model for cancer survivors fit the data well (χ 2 (374) = 3654.7, P < 0.001 (please make it 0.001 for all p values NOT .00l); comparative fit index = 0.98; root mean square error of approximation = 0.04). Although black cancer survivors were less likely to report good-to-excellent health, along with Hispanic survivors, they were more likely to continue to work after diagnosis compared with their white counterparts. Health insurance status and educational level were strongly and positively associated with health status and current employment. Age and time since diagnosis were not significantly associated with health status or employment, but there were significant differences by cancer site. ConclusionsA proportion of cancer survivors may continue to work because of employment-based health insurance despite reporting poor health and significant physical and mental health limitations. Acute and long-term health and social elsevier_AEP_7850

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“…Interestingly, we found a very significant difference in the prevalence of truncated DATE in normal, healthy AAs versus normal CCs (26% vs. 3%, respectively; P < 0.0001). It remains controversial as to why AA women have a higher rate of breast cancer at a younger age than do CC women (40,41). Our results showing that truncated DATE is present more frequently in normal AAs as compared with CCs may be one reason.…”

Section: Figurementioning

confidence: 99%

Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer

Ma¹,

DeFrances²,

Zou³

et al. 2009

J. Clin. Invest.

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The HGF gene is transcriptionally silenced in normal differentiated breast epithelial cells, but its repression fails to occur in mammary carcinoma tissues and cell lines. The molecular mechanisms underpinning aberrant HGF expression in breast cancer cells are unknown. Here we report the discovery of a DNA element located 750 bp upstream from the transcription start site in the human HGF promoter that acts as a transcriptional repressor and is a target of deletion mutagenesis in human breast cancer cells and tissues. This HGF promoter element consists of a mononucleotide repeat of 30 deoxyadenosines (30As), which we have termed "deoxyadenosine tract element" (DATE). Functional studies revealed that truncation mutations within DATE have profound local and global effects on the HGF promoter region by modulating chromatin structure and DNA-protein interactions, leading to constitutive activation of the HGF promoter in human breast carcinoma cell lines. We found that 51% of African Americans and 15% of individuals of mixed European descent with breast cancer harbor a truncated DATE variant (25As or fewer) in their breast tumors and that the truncated allele is associated with cancer incidence and aberrant HGF expression. Notably, breast cancer patients with the truncated DATE variant are substantially younger than those with a wild-type genotype. We also suggest that DATE may be used as a potential genetic marker to identify individuals with a higher risk of developing breast cancer.

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Prognostic significance of psychosocial factors in African‐American and white breast cancer patients

Cited by 84 publications

References 76 publications

Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity

Social regulation of leukocyte homeostasis: The role of glucocorticoid sensitivity

Working with cancer: health and employment among cancer survivors

Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer

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