Prognostic significance of proliferative and apoptotic fractions in low grade follicle center cell-derived non-Hodgkin's lymphomas

Czader, Magdalena; Mazur, Joanna; Pettersson, Mikael; Liliemark, Jan; Strömberg, Mats; Christensson, Birger; Tribukait, B.; Auer, Gert; Öst, Åke; Porwit, Anna

doi:10.1002/(sici)1097-0142(19960315)77:6<1180::aid-cncr26>3.0.co;2-x

Cited by 29 publications

(4 citation statements)

References 41 publications

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“…Our observation indicates that more active proliferating cells can be found in the DLBCL subgroup with favorable outcome probably suggesting that these tumors are sensitive to chemotherapy. This is in agreement with previous studies [32,33].…”

Section: Discussionsupporting

confidence: 94%

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Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

et al. 2008

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Section: Discussionsupporting

confidence: 94%

“…Previous studies in other NHLs like follicular lymphoma have shown that tumors with more proliferating cells respond better to chemotherapy and have better survival [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

et al. 2008

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“…index and good prognosis (32), others reached the opposite conclusion (33,34). Interestingly, a correlation has been established between radiation-induced apoptosis measured in vitro in cells obtained by cytology and early responses to in vivo radiotherapy in patients with low-grade nonHodgkin's lymphoma (8).…”

Section: Discussionmentioning

confidence: 99%

In vivo imaging of radiation-induced apoptosis in follicular lymphoma patients

Haas

Jong

Olmos

et al. 2004

International Journal of Radiation Oncology*Biology*Physics

120

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“…In this context, stimulating investigations to determine the dynamics of cell turnover have been carried out. However, evaluations between apoptotic and proliferative indices has been limited exclusively to malignant lymphomas so far [15,16,35,36,53]. For this reason, the present study was concentrated on the issue of whether reactive and neoplastic lesions of the bone marrow with extreme ranges of cell production -as reflected by cor- responding laboratory data -may also be characterized by significantly different turnover rates of hematopoiesis.…”

Section: Introductionmentioning

confidence: 99%

Hematopoietic turnover index in reactive and neoplastic bone marrow lesions: quantification by apoptosis and PCNA labeling

Thiele

Zirbes

Lorenzen

et al. 1997

Annals of Hematology

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In order to determine the dynamics of hematopoietic cell turnover, proliferative activity and incidence of apoptosis (programmed cell death) were evaluated in bone marrow trephine biopsies. Selection of patients (20 in each group) included in addition to a control group, idiopathic thrombocytopenia (ITP), reactive thrombocytosis (TH), secondary polycythemia-smokers' polyglobuly (PG), primary (essential-hemorrhagic) thrombocythemia (PTH), polycythemia vera (PV), and finally acute myeloid leukemia (AML). Apoptosis was demonstrated by the in situ end-labeling technique (ISEL) and proliferative activity by applying the monoclonal antibody PC10 raised against proliferating cell nuclear antigen (PCNA). To assess dynamic features of hematopoiesis, an index was calculated consisting of the ratio between PCNA-positive nuclei and the apoptotic cell fraction. This factor was termed the hematopoietic turnover index (HTI). Morphometric analysis revealed that the HTI was significantly increased in AML and PV. According to cell culture studies both disorders are characterized by either a prevalent proliferation of the myeloid or erythroid cell mass. On the other hand, PG, PTH, and TH showed no relevant enhancement of this index in comparison to the control specimen. In vitro experiment results are in keeping with the finding that PG and PTH are not associated with a significant expansion of the erythroid lineage (CFU-E). Similar to ITP and TH, in PTH megakaryocyte proliferation (CFU-MEG) is the predominant feature of cell turnover. Differences between PTH and TH are in line with the reduced in vitro formation of CFU-MEG in the latter disorder. In conclusion, our in situ study on turnover rates of the bone marrow in various neoplastic and reactive lesions extends previous experimental data on hematopoietic cell kinetics.

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Prognostic significance of proliferative and apoptotic fractions in low grade follicle center cell-derived non-Hodgkin's lymphomas

Cited by 29 publications

References 41 publications

Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

In vivo imaging of radiation-induced apoptosis in follicular lymphoma patients

Hematopoietic turnover index in reactive and neoplastic bone marrow lesions: quantification by apoptosis and PCNA labeling

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