Prognostic Significance of Preoperative Sarcopenia in Patients With Gastric Cancer Liver Metastases Receiving Hepatectomy

Xiong, Jianping; Wu, Yunzi; Hu, Haitao; Kang, Wenzhe; Li, Yang; Jin, Peng; Shao, Xinxin; Li, Weikun; Tian, Yantao

doi:10.3389/fnut.2022.878791

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…Additionally, it shows significant relation with the poor long-term prognosis among patients with GC receiving surgery (14). Our previous work indicated that sarcopenia effectively predicted prognosis of recurrence in patients with GCLM receiving hepatectomy (15). The Peking prognostic score (PPS), first proposed by Xiong et al, consists of sarcopenia and LCR and shows high relation to GC prognosis (16).…”

Section: Introductionmentioning

confidence: 99%

Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy

Xiong

et al. 2022

Front. Nutr.

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BackgroundThe present work evaluated how Peking prognostic score (PPS), the new prognostic index determined according to sarcopenia and lymphocyte-to-C-reactive protein ratio (LCR), was a prognostic factor for patients with gastric cancer liver metastases (GCLM) who received hepatectomy.MethodsThis work extracted information about patients with GCLM who underwent hepatectomy from June 2012 to May 2018. The PPS of the patients was calculated from sarcopenia status and LCR before surgery, and patients were then divided into three groups based on their PPS. This work also carried out univariate and multivariate analyses for identifying variables that were linked with overall survival (OS) together with recurrence-free survival (RFS) after hepatectomy among three groups according to PPS.ResultsThis work included 108 GCLM cases who received hepatectomy. All cases were classified into 3 groups, i.e., 26 (24.1%), 48 (44.4%), and 34 (31.5%) in groups 0–2, separately. PPS exhibited positive relation with age (p < 0.001), body mass index (BMI; p = 0.012), and liver metastasis number. The relapse rate after hepatectomy in patients with GCLM was 69.4%. Additionally, the remnant liver relapse rates of groups 0–2 were 80.0, 68.7, and 53.5%. Patients in group 0 had significantly increased remnant liver relapse rates when compared with those in groups 0 and 1. PPS was significantly related to relapse patterns (p = 0.003). Relative to group 0, those of the other 2 groups showed dismal OS [hazard ratio (HR) = 3.98, 7.49 for groups 1 and 2; p < 0.001] along with RFS (HR = 3.65, 5.33 for groups 1 and 2; p < 0.001). As revealed by multivariate analysis, PPS independently predicted OS (p < 0.001) together with RFS (p < 0.001).ConclusionThe PPS could be an easy nutrition-inflammation prognostic scoring system and an independent preoperative predictor of survival for GCLM cases after hepatectomy.

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Section: Introductionmentioning

confidence: 99%

Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy

Xiong

et al. 2022

Front. Nutr.

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Effect of sarcopenia and frailty on outcomes among patients with brain metastases

Lim,

Zhang,

Zheng

et al. 2024

J Neurooncol

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The Effects of Sarcopenia on Overall Survival and Postoperative Complications of Patients Undergoing Hepatic Resection for Primary or Metastatic Liver Cancer: A Systematic Review and Meta-Analysis

Giakoustidis,

Papakonstantinou,

Chatzikomnitsa

et al. 2024

JCM

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Background: Colorectal cancer is the third most common cancer worldwide, and 20–30% of patients will develop liver metastases (CRLM) during their lifetime. Hepatocellular carcinoma (HCC) is also one of the most common cancers worldwide with increasing incidence. Hepatic resection represents the most effective treatment approach for both CRLM and HCC. Recently, sarcopenia has gained popularity as a prognostic index in order to assess the perioperative risk of hepatectomies. The aim of this study is to assess the effects of sarcopenia on the overall survival (OS), complication rates and mortality of patients undergoing liver resections for HCC or CRLM. Methods: A systematic literature search was performed for studies including patients undergoing hepatectomy for HCC or CRLM, and a meta-analysis of the data was performed. Results: Sarcopenic patients had a significantly lower 5-year OS compared to non-sarcopenic patients (43.8% vs. 63.6%, respectively; p < 0.01) and a significantly higher complication rate (35.4% vs. 23.1%, respectively; p = 0.002). Finally, no statistical correlation was found in mortality between sarcopenic and non-sarcopenic patients (p > 0.1). Conclusions: Sarcopenia was significantly associated with decreased 5-year OS and increased morbidity, but no difference was found with regard to postoperative mortality.

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Prognostic Significance of Preoperative Sarcopenia in Patients With Gastric Cancer Liver Metastases Receiving Hepatectomy

Cited by 3 publications

References 40 publications

Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy

Peking prognostic score is a useful prognostic factor in patients with gastric cancer liver metastases receiving hepatectomy

Effect of sarcopenia and frailty on outcomes among patients with brain metastases

The Effects of Sarcopenia on Overall Survival and Postoperative Complications of Patients Undergoing Hepatic Resection for Primary or Metastatic Liver Cancer: A Systematic Review and Meta-Analysis

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