Prognostic significance of ploidy and S-phase fraction in primary intraoral squamous cell carcinoma and their corresponding metastatic lymph nodes

El-Deftar, MM; Gerzawi, S.M. El; Abdel-Azim, A.A.; Tohamy, Saied Mohamed

doi:10.1016/j.jnci.2011.12.001

Cited by 12 publications

(12 citation statements)

References 25 publications

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“…Several analyses of CRC have shown that the degree of aneuploidy in metastases is similar or heightened in comparison to the primary tumour [133–136]. In contrast, some investigations show that metastases seem to be diploid more often than the primary tumours they originated from [137–140]. A recent investigation comparing primary oral squamous cell carcinomas (OSCCs) and their lymph node metastases (LMNs) found similar rates of aneuploidy in primary tumours and lymph node metastases [141].…”

Section: Introductionmentioning

confidence: 99%

The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity

2019

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Many cancers possess an incorrect number of chromosomes, a state described as aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of continuous chromosome mis-segregation. CIN is believed to endow tumours with enhanced evolutionary capabilities due to increased intratumour heterogeneity, and facilitating adaptive resistance to therapies. Recently, however, additional consequences and associations with CIN have been revealed, prompting the need to understand this universal hallmark of cancer in a multifaceted context. This review is focused on the investigation of possible links between CIN, metastasis and the host immune system in cancer development and treatment. We specifically focus on these links since most cancer deaths are due to the consequences of metastasis, and immunotherapy is a rapidly expanding novel avenue of cancer therapy.

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Section: Introductionmentioning

confidence: 99%

The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity

2019

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“…(89) El-Deftar el al (2012), (90) reported that the SPF aneuploid tumors were substantially more prevalent than diploid cancers. Contrastingly Zahran et al (2018) (91) found that all diploid tumors have S-phase percentage less than those of the lowest aneuploid cell line but with no significant difference.…”

Section: Discussionmentioning

confidence: 84%

Therapeutic efficacy of time-dependent cetuximab on experimentally induced hamster buccal pouch carcinoma

Shamia

Abd-Alhafez

Alqalshy

et al. 2022

ijhs

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Purpose: This study aimed to determine the cetuximab therapeutic potential in the time-dependent fashion in experimentally induced hamster buccal pouch (HBP) carcinoma. Material and methods: Forty Syrian male hamsters were classified into four equal groups (G) of ten each. GI: The animals remained untreated to act as negative controls. The right pouches of animals in GII, GIII, and GIV were painted three times a week for 14 weeks (w)s with 7,12-dimethylbenz (a) anthracene (DMBA). GII: No additional treatment was administered. While, the animals in GIII and GIV were treated differently. Those in GIII received cetuximab intraperitoneally (IP) three intervals a week for three (w)s, whereas those in GIV received cetuximab IP three intervals for six (w)s. After the end of the experiment, the gross observations were made, and blood samples (2ml) were withdrawn from the inner canthus of the eye for analysis of whole white blood cells (WBCs) and oxidative stress markers [glutathione (GSH) and malondialdehyde (MDA) levels]. All pouches were surgically bisected for preparation for Hematoxylin and Eosin (H&E) stain and immunohistochemistry (IHC) stain using epidermal growth factor receptor (EGFR). Other fresh tissue was used for DNA detection through a flow cytometry (FCM) test.

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“…Though this technique is relatively quicker, image analysis has certain advantages over flow cytometry, such as the presence of internal reference standard and an ability to generate quality histograms uncontaminated by debris and clumps of nuclei . Various studies have shown a wide range of aneuploidy by flow cytometry in squamous cell carcinoma of the oral cavity …”

Section: Discussionmentioning

confidence: 99%

Evaluation of brush cytology and DNA image cytometry for the detection of cancer of the oral cavity

Kaur

Handa

Mohan

et al. 2016

Diagnostic Cytopathology

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Prognostic significance of ploidy and S-phase fraction in primary intraoral squamous cell carcinoma and their corresponding metastatic lymph nodes

Abstract: High SPF of primary OSCC tumors assessed by FCM was significantly associated with decreased disease free survival rates. DNA ploidy showed no relationship to bad prognostic indicators in either primary OSCC or their metastatic tumors.

Cited by 12 publications

References 25 publications

The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity

The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity

Therapeutic efficacy of time-dependent cetuximab on experimentally induced hamster buccal pouch carcinoma

Evaluation of brush cytology and DNA image cytometry for the detection of cancer of the oral cavity

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