Prognostic significance of plasma chemerin levels in patients with gastric cancer

Zhang, Jian; Jin, Huicheng; Zhu, Akao; Ying, Rongchao; Wei, Wei; Zhang, Fang‐Jie

doi:10.1016/j.peptides.2014.08.007

Cited by 44 publications

(29 citation statements)

References 29 publications

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“…In advanced stages of gastric cancer, high grade/aggressive cancer, serum chemerin concentration is higher than levels demonstrate in stage 1 [127]. In support of this others demonstrate that an elevation in preoperative chemerin concentration is associated with poor post-operative prognosis and survival gastric cancer [128]. Chemerin promotes the progression of gastric cancer by increasing its invasiveness, the spread of cancer outside of the tissue the cancer has originated, but not proliferation [127].…”

Section: Chemerinmentioning

confidence: 78%

Adipose tissue, obesity and adipokines: role in cancer promotion

Booth

Magnuson

Fouts

et al. 2015

Hormone Molecular Biology and Clinical Investigation

239

235

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Adipose tissue is a complex organ with endocrine, metabolic and immune regulatory roles. Adipose depots have been characterized to release several adipocytokines that work locally in an autocrine and paracrine fashion or peripherally in an endocrine fashion. Adipocyte hypertrophy and excessive adipose tissue accumulation, as occurs during obesity, dysregulates the microenvironment within adipose depots and systemically alters peripheral tissue metabolism. The term "adiposopathy" is used to describe this promotion of pathogenic adipocytes and associated adipose -elated disorders. Numerous epidemiological studies confirm an association between obesity and various cancer forms. Proposed mechanisms that link obesity/adiposity to high cancer risk and mortality include, but are not limited to, obesity-related insulin resistance, hyperinsulinemia, sustained hyperglycemia, glucose intolerance, oxidative stress, inflammation and/or adipocktokine production. Several epidemiological studies have demonstrated a relationship between specific circulating adipocytokines and cancer risk. The aim of this review is to define the function, in normal weight and obesity states, of wellcharacterized and novel adipokines including leptin, adiponectin, apelin, visfatin, resistin, chemerin, omentin, nesfatin and vaspin and summarize the data that relates their dysfunction, whether associated or direct effects, to specific cancer outcomes. Overall research suggests most adipokines promote cancer cell progression via enhancement of cell proliferation and migration, inflammation and anti-apoptosis pathways, which subsequently can prompt cancer metastasis. Further research and longitudinal studies are needed to define the specific independent and additive roles of adipokines in cancer progression and reoccurrence.

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Section: Chemerinmentioning

confidence: 78%

Adipose tissue, obesity and adipokines: role in cancer promotion

Booth

Magnuson

Fouts

et al. 2015

Hormone Molecular Biology and Clinical Investigation

239

235

View full text Add to dashboard Cite

show abstract

“…Digestion 2020;101:571-578 DOI: 10.1159/000501477 melanoma [37]. By contrast, chemerin may be correlated to tumor progression, such as esophageal squamous cell carcinoma [38], gastric cancer [25,39], and hepatocellular carcinoma [40]. In our study, patients with a higher chemerin level had a 3-fold increased risk of developing CRA, and a significant positive correlation was observed between serum chemerin level and the number of CRA, which is a precancerous lesion of CRC [41].…”

Section: Discussionmentioning

confidence: 99%

Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men

et al. 2019

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Background: Obesity and metabolic syndrome are considered the risk factors of colorectal adenoma (CRA) and colorectal cancer (CRC). Chemerin is a novel adipocytokine associated with the development of gastric cancer, esophageal cancer, hepatocellular carcinoma, and CRC. However, the relationship between chemerin levels and CRA remains unclear. Objective: This study is aimed at investigating the association between serum chemerin levels and the development of CRA. Methods: We conducted a total colonoscopy-based cross-sectional case-control study of 80 male patients with CRA and 80 male age-matched control individuals without CRA, according to their endoscopic findings. Serum chemerin concentrations were measured using a sandwich enzyme-linked immunosorbent assay kit, and the OR of CRA was calculated via logistic regression analysis. Results: The mean serum chemerin level of the CRA group was significantly higher than that of the control group (7.9 ± 0.41 vs. 5.16 ± 0.34 ng/mL, p < 0.001). Serum chemerin level was positively correlated to the development of CRA (r = 0.34). Multivariate logistic regression analysis revealed that a high chemerin level was independently associated with the development of CRA (OR 2.82, 95% CI 1.39-5.72). Conclusions: Our findings indicated that increased serum chemerin levels are positively associated with the presence of CRA in men. Chemerin may play an important role in the development of CRA.

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“…De Novo [360,[369][370][371][372][373][374][375][376][377][378][379][380][381][382][383] Starker Konsens (100 %)…”

Section: Level Of Evidence 2amentioning

confidence: 99%

“…Für alle Marker reicht die berichtete Sensitivität und Spezifität für die Primärdiagnostik nicht aus. Zudem sind die Marker oft nicht an großen Kollektiven prospektiv validiert, sondern nur retrospektiv an Fallkontrollstudien untersucht worden [374,380,381].…”

Section: Hintergrundunclassified