Prognostic significance of peritoneal washing cytology in Thai patients with gastric adenocarcinoma undergoing curative D2 gastrectomy

Euanorasetr, Chakrapan; Lertsithichai, Panuwat

doi:10.1007/s10120-006-0402-7

Cited by 22 publications

(25 citation statements)

References 32 publications

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“…Many studies have found a link between progression of tumour through the muscle layer, lymph node metastasis and angiolymphatic invasion with the presence of malignant cells in the peritoneal cavity [9,10,11]. However unlike the above studies our analysis showed that positive cytology was significantly associated with the T (depth of tumour invasion) stage and resectability status of the tumors.…”

Section: Discussioncontrasting

confidence: 84%

Significance of peritoneal cytology in patients with gastric cancer: a mono institutional experience with 50 patients

et al. 2016

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34histologically proven gastric cancer cases. All patients who were found to have definitive organ metastasis on preoperative imaging were excluded from the study. Study techniqueAll 50 patients underwent exploratory laparotomy via long midline incision. On opening the abdomen, 500 ml sterile normal saline was instilled into the peritoneal cavity which was manually dispersed by shaking the abdomen. The primary tumour was not touched.A washing sample (100 ml) was aspirated from the peritoneal cavity. The specimen was immediately carried to the department of pathology, were sample was centrifuged to make smears which were fixed and stained with PAP (Papanicolau) stain and the slides examined under light microscope.Peritoneal cytology was considered positive when malignant cancer cells were found in the smears. Medical records of each patient were then reviewed in detail and relevant clinical and pathological information were obtained .The patients were then followed for recurrence of disease and mortality either in our follow up clinic or by telephonic conversation. Associations between cytology status (CY) and clinicopathological variables and effect of cytology status on overall survival was evaluated. Study toolsPre structured questionnaire, preoperative staging investigations, pathology reports, cytology result. Data analysisDetailed history and examination and all relevant results were recorded using pre structured data sheet, the final pathology and cytology results were obtained and patient were followed up for an average of 15 months. All these data was entered into a Microsoft soft excel sheet and a master chart was prepared. This was used for making tables and diagrams to represent the data. Statistical correlation was done and tests of significance was calculated. Statistical analysis was done using statistical software R, version 2.13.0.

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Section: Discussioncontrasting

confidence: 84%

Significance of peritoneal cytology in patients with gastric cancer: a mono institutional experience with 50 patients

et al. 2016

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“…6,7,[10][11][12][13][14] The present study's CY1 rate of 11% was relatively low, even though the patients underwent CY at 3 cavities; however, our figure is not simply comparable with other studies because of the difference in the patients' backgrounds. When we subclassified patients according to the depth of tumor invasion, the CY1 rate in the patients with serosa-invading tumors was 40% (data not shown), which is greater than those of the previous studies.…”

Section: Discussioncontrasting

confidence: 72%

Prognostic significance of peritoneal lavage cytology at three cavities in patients with gastric cancer

Kano

Kosugi

Ishikawa

et al. 2015

Surgery

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“…One article included only locally advanced tumors [24]. The remainder included both early and advanced cancers [21][22][23].…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

“…Of the 17 articles where conventional cytology was used to detect IFCCs, 11 commented on the risk of peritoneal recurrence [23,24,30,31,33,41,42,[44][45][46][47]. Table 1 summarizes the results, with conventional cytology predicting peritoneal recurrence with an accuracy of 73-91.9%, sensitivity of 11.1-80%, and specificity of 86.4-100%.…”

Section: Prediction Of Peritoneal Recurrencementioning

confidence: 99%

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A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

et al. 2011

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Background There is lack of uniformity in the utilization of peritoneal cytology in gastric cancer management. The identification of intraperitoneal free cancer cells (IFCCs) is believed to confer poor prognosis. However, while some of these patients are palliated, others may undergo more aggressive therapies. In this review, we aimed to identify and synthesize findings on the use of peritoneal cytology in predicting peritoneal recurrence and overall survival in curative gastric cancer patients. Methods Electronic literature searches were conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 31, 2009. We determined the accuracy, sensitivity, and specificity of peritoneal cytology in predicting peritoneal recurrence based on four techniques-conventional cytology, immunoassay, immunohistochemistry, and reverse transcriptase-polymerase chain reaction. Recurrence rates and overall survival rates for curative patients were determined, based on positivity or negativity for IFCCs. Results Twenty-eight articles were included. All four techniques showed wide variations in accuracy, sensitivity, and specificity in predicting peritoneal recurrence. Recurrence rates for patients positive for IFCCs ranged from 11.1 to 100%, while those negative for IFCCs had recurrence rates of 0-51%. Overall survival was significantly reduced for patients with positive IFCCs. Short follow-up periods and possible duplication of results may limit result interpretation. Conclusion The presence of IFCCs appears to increase the risk of peritoneal recurrence and is associated with worse overall survival in gastric cancer patients. Further incorporation of peritoneal cytology in clinical decisionmaking in gastric cancer depends on the development of a consistently accurate and rapid IFCC detection method.

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Prognostic significance of peritoneal washing cytology in Thai patients with gastric adenocarcinoma undergoing curative D2 gastrectomy

Cited by 22 publications

References 32 publications

Significance of peritoneal cytology in patients with gastric cancer: a mono institutional experience with 50 patients

Significance of peritoneal cytology in patients with gastric cancer: a mono institutional experience with 50 patients

Prognostic significance of peritoneal lavage cytology at three cavities in patients with gastric cancer

A systematic review of the accuracy and utility of peritoneal cytology in patients with gastric cancer

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