Prognostic Significance of P27 and Cyclin D1 Co-Expression in Laryngeal Squamous Cell Carcinoma: Possible Target for Novel Therapeutic Strategies

Arisi, E.; Pruneri, Giancarlo; Carboni, Nadia; Sambataro, G.

doi:10.1080/1120009x.2004.11782372

Cited by 6 publications

(3 citation statements)

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“…However, a subsequent Phase II study of lapatinib in 42 patients with advanced SCCHN demonstrated no responses and disappointing median PFS (1.6 months), despite modest rates of stable disease (37% in EGFR inhibitor-naive patients, and 20% in the remainder) [86]. There are multiple other targets under investigation, such as cyclin D1 (the expression of which has been shown to correlate with poor prognosis) [87].…”

Section: Targeted Therapymentioning

confidence: 99%

Combined modality treatment of laryngeal squamous cell carcinoma

Devlin

Langer

2007

Expert Review of Anticancer Therapy

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Squamous cell carcinoma of the larynx is a major public health concern; it causes substantial morbidity and mortality, and arises chiefly as a result of tobacco and alcohol consumption. Early stage disease is best treated with radiation or surgery alone, but for patients with more locally advanced squamous cell carcinoma of the larynx, combined modality treatment has been shown to benefit selected patients, particularly when cisplatin-based chemotherapy and concurrent radiation therapy are employed, with or without altered fractionated radiation therapy. Substantial laryngectomy-associated quality-of-life decrements can be avoided in selected, potentially resectable patients with organ-sparing approaches, without sacrificing survival. Recently, trials have addressed the role of targeted systemic agents to the epidermal growth factor receptor, and other targets are under investigation. The addition of induction chemotherapy to concurrent chemoradiotherapy is a promising treatment strategy that warrants further evaluation, but has not yet emerged as a standard of care; the toxicity of such regimens must be balanced with the potential benefits on a case-by-case basis, and functional outcomes are often quite variable. Treatment planning, management and follow-up are complex, and thus should ideally be performed in a comprehensive, multidisciplinary fashion, in a center accustomed to a high volume of such cases. Future research directions are described herein.

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Section: Targeted Therapymentioning

confidence: 99%

Combined modality treatment of laryngeal squamous cell carcinoma

Devlin

Langer

2007

Expert Review of Anticancer Therapy

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“…So far, many research literatures have confirmed that cell cycle regulation get involved in the pathogenesis of laryngeal cancer. For example, overexpression of cyclin-D1 can be used as a marker to predict relapse in patients with LSCC after primary curative resection ( 6 ); circMYLK/miR-195/cyclin D1 regulatory axis could affect the proliferation and cell cycle progression of LSCC cells ( 7 ); in relation to the simultaneous expression of p27 protein and cyclin D1, the patients with a cyclin D1+/p27- phenotype had the poorest disease-free and overall survival rates ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

DIAPH1 Promotes Laryngeal Squamous Cell Carcinoma Progression Through Cell Cycle Regulation

et al. 2021

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The diaphanous related formin 1 (DIAPH1) protein is involved in the regulation of dynamic cytoskeleton reorganization, which is closely related to mitosis and the cell cycle. Cell cycle disorders are generally regarded as important underlying causes of many cancers. In the current study, we have revealed that DIAPH1 expression is an independent prognostic factor for overall survival in patients with laryngeal squamous cell carcinoma (LSCC) and that DIAPH1 promotes colony formation, cell proliferation, and G1/S progression in LSCC cells. Additionally, DIAPH1 promotes growth of AMC-HN-8 LSCC-derived tumors in vivo. In this study, RNA-sequencing analysis revealed that DIAPH1 knockdown led to changes in the expression of genes associated with signaling during the cell cycle. Using western blot analyses, we further demonstrated that DIAPH1 knockdown resulted in upregulation of p21Waf1/Cip1, p19Ink4d, p27Kip1, and p16Ink4a and downregulation of cyclinA2, cyclinD1, CDK2, CDK4, and CDK6. These results suggest that DIAPH1 influences the expression of genes in several signaling pathways and promotes LSCC progression by regulating the cell cycle.

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“…40,41,44 Clinically, downregulation of p27 has been shown to correlate with poor survival in several types of cancer, [55][56][57] while laryngeal cancer patients with a p27 positive phenotype showed better prognosis. [58][59][60] p21 and p27 have also been shown to play a role in solitary cell dormancy. The effect of p21 and p27 expression on cancer cells in vitro was clarified in studies in which increasing p21 or p27 expression inhibited cell growth and increased the number of cells arrested in the G 1 phase.…”

Section: Molecular Basis For Dormancymentioning

confidence: 99%

Dormancy of Solitary Metastatic Cells

Townson¹,

Chambers²

2006

Cell Cycle

161

113

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After arriving in a secondary site metastatic cells may begin proliferating, undergo apoptosis or remain as solitary dormant cells. The process of metastasis, although dangerous, is extremely inefficient with the majority of the cells undergoing apoptosis and thus becoming clinically irrelevant. Of the cells that begin proliferating, the few that make it past the micrometastasis stage may be of immediate clinical relevance. Dormant cells, while not of immediate clinical concern, are believed to be at least in part responsible for cancer recurrence that can occur decades after apparently successful initial treatment. Dormant solitary cells are different from "dormant" micrometastases, in which active proliferation is balanced by apoptosis. The mechanisms of cell cycle regulation and the function of the molecules regulating this process are well understood. However, there is relatively little known about the mechanisms controlling cell cycle regulation and dormancy of solitary metastatic cells. There are several inherent difficulties impeding the study of solitary cells. This review paper will examine the models used in the study of dormant solitary metastatic cells, methods of imaging and studying these cells, the molecular mechanisms believed to be responsible for solitary cell dormancy, and finally the unique treatment challenges posed by these cells.

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Prognostic Significance of P27 and Cyclin D1 Co-Expression in Laryngeal Squamous Cell Carcinoma: Possible Target for Novel Therapeutic Strategies

Cited by 6 publications

References 0 publications

Combined modality treatment of laryngeal squamous cell carcinoma

Combined modality treatment of laryngeal squamous cell carcinoma

DIAPH1 Promotes Laryngeal Squamous Cell Carcinoma Progression Through Cell Cycle Regulation

Dormancy of Solitary Metastatic Cells

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