Prognostic significance of osteopontin in hepatitis B virus-related hepatocellular carcinoma

Xie, Hui; Song, Jae Yun; Du, Rui; Liu, K.; Wang, J.; Tang, Hongwei; Bai, Feihu; Liang, Jie; Lin, Tao; Liu, J.; Fan, Daiming

doi:10.1016/j.dld.2006.10.015

Cited by 53 publications

(50 citation statements)

References 14 publications

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“…Although the identification of many prognostic markers of HCC, such as vascular endothelial growth factor, osteopontin, and transforming growth factor-b, resulted from extensive clinical as well as basic research efforts, the available markers still are not able to accurately predict the survival of patients with HCC. [9][10][11] Thus, exploring new prognosis markers of HCC is of great importance.…”

mentioning

confidence: 99%

p53‐induced RING‐H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection

Wang

Yang

Guo

et al. 2009

Cancer

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Novel copolyacrylates containing various molar ratios of 5,10,15‐tri[p‐(9‐methoxy‐triethylenoxy)phenyl]‐20‐(p‐acryloxyphenyl)porphyrin units in the chains have been synthesized, and their chemical structure was determined by NMR and MALDI‐TOF mass spectrometry. Sensing response of the synthesized copolymers has been tested for trifluoroacetic and hydrochloric acids and nitrogen dioxide analytes. The reported sensing data indicate that porphyrin units are interacting with analytes in a reversible fashion. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011

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mentioning

confidence: 99%

p53‐induced RING‐H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection

Wang

Yang

Guo

et al. 2009

Cancer

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“…In the following survival analysis, HIF-1a III and IV were considered high expression patterns while the remaining cases were considered as low expression patterns [7,11]. Expression of HBx was determined by assessing the percentage of decorated tumor cells and the staining intensity semiquanitatively [20]. The percentage of positive cells was rated as follows: 0 (no cell), 1 (1-25%), 2 (26-50%), 3 (51-75%), or 4 (76-100%).…”

Section: Immunohistochemistry Analysismentioning

confidence: 99%

“…When a tumor was detected with sonography or CT, it was recorded as a recurrence. Disease-free survival was measured from the date of hepatectomy to the time the tumor recurred, and overall survival was measured from the date of hepatectomy until the patient's death [20]. The endpoint for follow-up was set at the 5th year and the survival time was set at 60 months for those who survived for more than 5 years.…”

Section: Patient Follow-upmentioning

confidence: 99%

The Expression of Hypoxia-Inducible Factor-1α in Hepatitis B Virus-Related Hepatocellular Carcinoma: Correlation with Patients’ Prognosis and Hepatitis B Virus X Protein

et al. 2008

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Hypoxia inducible factor-1alpha (HIF-1alpha) was well correlated with carcinogenesis and tumor progression in many kinds of cancer. In this study, high expression of HIF-1alpha was found in 37 of the 72 (51.39%) tumor specimens, and significantly correlated with venous invasion and lymphonode invasion. Patients with high expression of HIF-1alpha had a significantly shorter overall survival rate and disease-free survival rate than those with low expression. Multivariate analysis showed high HIF-1alpha expression was a borderline independent factor of overall survival. HIF-1alpha expression was also found to be significantly correlated with the expression of hepatitis B virus X protein (HBx), and over-expressed HBx upregulated HIF-1alpha protein expression in vitro. These results suggested that HIF-1alpha, which was partially regulated by HBx, might be a prognostic marker of HBV-related HCC patients.

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“…Its overexpression is associated with capsular infiltration, venous invasion, lymph node metastasis, and worse prognosis [68] . Whereas expression of KiSS-1, a metastasis suppressor gene, correlates with a shorter disease-free and overall survival and serves as an independent prognostic factor [69] .…”

Section: Metastasismentioning

confidence: 99%

Hepatocellular tumors: Immunohistochemical analyses for classification and prognostication

2011

Chin. J. Cancer Res.

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Following the classification of hepatocellular nodules by the International Working Party in 1995 and further elaboration by the International Consensus Group for Hepatocellular Neoplasia in 2009, entities under the spectrum of hepatocellular nodules have been better characterized. Research work hence has been done to answer questions such as distinguishing high-grade dysplastic nodules from early hepatocellular carcinoma (HCC), delineating the tumor cell origin of HCC, identifying its prognostic markers, and subtyping hepatocellular adenomas. As a result, a copious amount of data at immunohistochemical and molecular levels has emerged. A panel of immunohistochemical markers including glypican-3, heat shock protein 70 and glutamine synthetase has been found to be of use in the diagnosis of small, well differentiated hepatocellular tumors and particularly of HCC. The use of liver fatty acid binding protein (L-FABP), β-catenin, glutamine synthetase, serum amyloid protein and C-reactive protein is found to be helpful in the subtyping of hepatocellular adenomas. The role of tissue biomarkers for prognostication in HCC and the use of biomarkers in subclassifying HCC based on tumor cell origin are also discussed.

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Prognostic significance of osteopontin in hepatitis B virus-related hepatocellular carcinoma

Cited by 53 publications

References 14 publications

p53‐induced RING‐H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection

p53‐induced RING‐H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection

The Expression of Hypoxia-Inducible Factor-1α in Hepatitis B Virus-Related Hepatocellular Carcinoma: Correlation with Patients’ Prognosis and Hepatitis B Virus X Protein

Hepatocellular tumors: Immunohistochemical analyses for classification and prognostication

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