Prognostic significance of noncardiac syncope in the general population: A systematic review and meta‐analysis

Abstract

This study-level meta-analysis showed that among older, diabetic and/or hypertensive individuals, history of noncardiac/unexplained syncope, even in the absence of an obvious cardiac etiology, is associated with higher all-cause mortality.

Pacing therapy in the management of unexplained syncope: a tertiary care centre prospective study

“…Finally, although the number of patients who died during the follow-up period was relatively small, there was a distinct correlation between recurrent syncope and increased mortality, in concordance with our previous reports 28 29. Thus, clinicians should be vigilant when syncope recurs as it may indicate further deterioration of cardiovascular and autonomic systems or be a red flag signalling increased risk of falls, fractures, hospital admissions and other potentially life-threatening conditions.…”

Do implantable loop recorders impact the survival of patients with recurrent unexplained syncope?

“…This study adds to a recent strand of literature on life expectancy of patients with unexplained syncope. Two large claim data analysis have shown higher rates of cardiovascular death as well as all-cause mortality in patients with admission for unexplained syncope compared to a control group without syncope [3,4]. This study sheds light on the possible causes of the lower life expectancy of syncope patients and the importance of diagnosing.…”

“…When syncope remains undiagnosed and untreated, it can have severe consequences. Several studies have documented worse survival in patients with syncope than in a control group without syncope [3,4]. Syncope might be a first symptom of underlying cardiovascular disease.…”

The Impact of a Nurse‐Led Syncope Clinic: Experience from a single UK tertiary center

“…[5][6][7] Studies suggest that neurally-mediated syncope carries a benign prognosis whilst cardiac syncope and unexplained syncope carry significantly increased mortality risk. 3,4,8 The reported mortality risk following syncope admission is highly variable, ranging from 1.9% to 13% at 1 year. 7,[9][10][11] Numerous risk scores have been developed to help identify patients at higher risk and guide decisions regarding hospital admission versus outpatient investigation.…”

“…Syncope is a common hospital presentation associated with increased morbidity, mortality, and significant healthcare burden 1‐4 and accounts for 1% of visits to the emergency department (ED) 5‐7 . Studies suggest that neurally‐mediated syncope carries a benign prognosis whilst cardiac syncope and unexplained syncope carry significantly increased mortality risk 3,4,8 . The reported mortality risk following syncope admission is highly variable, ranging from 1.9% to 13% at 1 year 7,9‐11 .…”