Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis

Yodying, Hariruk; Matsuda, Akihisa; Miyashita, Masao; Matsumoto, Satoshi; Sakurazawa, Nobuyuki; Yamada, Marina; Uchida, Eiji

doi:10.1245/s10434-015-4869-5

Cited by 321 publications

(273 citation statements)

References 50 publications

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“…This finding is consistent with other smaller studies demonstrating that elevated NLR portends poor prognosis in solid tumor malignancies. [1][2][3][4][5][6][7][8][9][10][11][12][13] Other studies in patients with hepato-pancreato-biliary (HPB) cancers agree with the findings presented in this paper. In a study of 452 patients who underwent a HPB procedure for malignant disease, NLR >5 was found to be associated with worse OS.…”

Section: Discussionsupporting

confidence: 92%

“…Elevated NLR is independently associated with worse outcomes in cancers of the breast, 1,2 thyroid, 3 colon, 4 stomach, 5 prostate, 6 lung, 7 adrenal, 8 pancreas 9,10 urogenital tract, 11 esophagus 12 and in glioblastoma, 13 as well as hematologic cancers, including multiple myeloma 14 and diffuse large B-cell lymphoma. 15 According to a recent systematic review and meta-analysis including 100 studies and greater than 40,000 patients, high NLR is associated with adverse overall survival (OS) in many solid tumors.…”

Section: Introductionmentioning

confidence: 99%

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Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

Beal

Wei

Ethun

et al. 2016

HPB

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

Beal

Wei

Ethun

et al. 2016

HPB

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“…For these reasons, the ratio between these two leukocyte subgroups is used as a predictive and prognostic marker in inflammatory events (12,13), cardiovascular diseases (7-9,11,14-17) and cancer cases (18)(19)(20)(21).…”

Section: Resultsmentioning

confidence: 99%

An evaluation of the neutrophil-to-lymphocyte ratio as a prognostic and predictive marker in thromboangiitis obliterans

Altun¹,

Hemsinli²

2017

J Turgut Ozal Med Cent

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Aim: The aim of this study was to investigate whether the neutrophil/lymphocyte ratio is an independent predictor of poor prognosis, mortality, co-morbidities, critical limb ischmemia, amputation, or a potential prognostic biomarker predicting pathological and survival outcomes in thromboangiitis obliterans. We also investigated whether there was any relation between an increased neutrophil/lymphocyte ratio in patients with Buerger's disease and amputation, the ultimate outcome of poor prognosis. Material and Methods:The hospital records of patients treated, followed-up and diagnosed with thromboangiitis obliterans were analyzed retrospectively. Surgical procedures performed and medical treatments applied were recorded from patients' clinical data. Extremities exposed to the disease during its course were identified. Amputations were recorded as minor and major. Neutrophil and lymphocyte values were recorded from peripheral blood samples at time of first presentation to hospital, with the neutrophil/ lymphocyte ratio being calculated from these. One hundred ten subjects were finally enrolled as the patient group (TAO; n=110). A control group (n=49) was established consisting of smoker volunteers with no health problems. Statistical changes in neutrophil/ lymphocyte ratio values between the groups were investigated. Results: No statistically significant difference was observed between the two groups' basic characteristics. In terms of neutrophil/ lymphocyte ratio values, a statistically significant increase was observed in the patient group compared to the control group. We observed no statistical correlation between amputations and neutrophil/lymphocyte ratio values. Conclusions: We think that the neutrophil / lymphocyte ratio, obtained easily and cheaply from routine peripheral blood samples, may be of clinical benefit in thromboangiitis obliterans.

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“…Especially, increased NLR, PLR, and MPV were associated with some types of cancer (21,22). Increased NLR and MPV are also associated with inflammatory diseases (23).…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Hemocytometer Parameters as Potential Biomarkers in Benign Multinodular Goiter and Papillary Thyroid Carcinoma

Uysal¹,

Ceylan²,

Sezgın³

et al. 2017

Iran Red Crescent Med J

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Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis

Abstract: NLR and PLR are associated with tumor progression and are predictive of poorer survival in patients with esophageal cancer. These ratios may thus help to inform treatment decisions and predict treatment outcomes.

Cited by 321 publications

References 50 publications

Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

Elevated NLR in gallbladder cancer and cholangiocarcinoma – making bad cancers even worse: results from the US Extrahepatic Biliary Malignancy Consortium

An evaluation of the neutrophil-to-lymphocyte ratio as a prognostic and predictive marker in thromboangiitis obliterans

Evaluation of Hemocytometer Parameters as Potential Biomarkers in Benign Multinodular Goiter and Papillary Thyroid Carcinoma

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