Prognostic significance of nestin in primary malignant melanoma of the oral cavity

Abstract

Several studies have examined the correlation between nestin expression and the degree of tumor invasion in cutaneous melanoma. However, no information has been reported on nestin in primary mucosal melanoma of the head and neck. The present study examined the expression and prognostic significance of nestin in patients with primary mucosal melanoma of the oral cavity. Nestin expression was examined immunohistochemically in 39 patients (six oral melanoma in-situ cases and 33 invasive oral melanoma cases) and analyzed for association with disease progression. Age, sex, anatomic site, stage, level of invasion, regional lymph node metastasis, surgical margin involvement, and treatment modality were also analyzed. In the 33 invasive melanoma cases, invasion depth correlated significantly with prognosis in univariate and multivariate analyses. High-intensity nestin staining was observed in 14 of the 33 cases and a high proportion of nestin-positive cells was observed in 16 cases. In stage III oral melanoma cases, nestin expression was not significantly associated with disease progression. However, in stage IV cases, both the intensity and the proportion of nestin expression were significantly associated with disease progression (P=0.022 and 0.005, respectively). In all 33 invasive cases, multivariate analyses showed that both the intensity and the proportion of nestin were significantly associated with a poor prognosis (P=0.014 and 0.009; hazard ratio, 3.59 and 4.05; 95% confidence interval, 1.29-9.98 and 1.42-11.56, respectively). In conclusion, nestin can be a valuable prognostic indicator in the advanced-stage (stage IV) cases of oral mucosal melanoma.

Undifferentiated sinonasal malignant melanoma: A case report

“…SOX2, CD133 and Nestin have been reported as cancer stem cell markers in melanoma (19)(20)(21). In the present study, the tumor cells of undifferentiated MM expressed CD133 and SOX2.…”

Nestin Expression Is Associated with Relapses in Head and Neck Lesions

“…In the OSCC, 27.3% of the samples were negative for nestin, and expression was intense (grades 2 and 3) in 54.6% of the cases, but we could not establish a relationship with mortality, although to the limited number of cases. In relation to the oral cavity, Kuk et al [ 27 ] found that, in a series of 39 oral melanomas (6 in situ and 36 invasive), found the same as Mascolo et al [ 20 ], this is a relationship of nestin expression (intensity and proportion) and disease progression, as well as a worse prognosis (Hazard ratio 3.59 for intensity and 4.05 for proportion). Ravindran and Devaraj [ 28 ] studied the expression pattern and prognostic significance of two neural stem cell markers, nestin and musashi-1, in oral cancer.…”

Prognostic value of ALDH1 and Nestin in advanced cancer: a systematic meta-analysis with trial sequential analysis

“…A flow diagram of the literature search procedure is presented in Figure 1. After applying the eligibility criteria, a total of 20 studies published from 2010 to 2018 were included in the metaanalysis, 26,27,[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] including 2050 patients with advanced cancer. These studies were evaluated against the REMARK criteria, with a mean REMARK score of 20.…”