Prognostic significance of microvessel density and vascular endothelial growth factor expression in advanced ovarian serous carcinoma

Abstract

The aim of the study was to test the prognostic value of the microvessel density (MVD) within the tumor and the vascular endothelial growth factor (VEGF) expression on clinical response to chemotherapy, on brief disease-free interval, and on cause-specific survival in advanced ovarian serous carcinoma. We evaluated 83 ovarian carcinomas homogeneous for stage, type and grade histologic, surgical, and chemotherapeutic treatment. Brief disease-free interval and cause-specific survival rates (Kaplan–Meier method) were compared using the log-rank test. A multivariate analysis (Cox-proportional hazards model) was used to determine the independent effect of each variable on prognosis. Overall 60 and 120 months cause-specific survival rates were 27.7% and 2.4%, respectively. The brief disease-free interval rate was 66.2%. In univariate analysis, VEGF (P = 0.0001 and P = 0.016), MVD (P < 0.0005), and the FIGO stage IIIC even more than FIGO stage IIIA (P = 0.01 and P < 0.0005, respectively) were associated with survival and brief disease-free interval, and the residual tumor was associated with survival (P = 0.021). In multivariate analysis, the factors that were independent predictors of survival were MVD (P < 0.0005), VEGF (P = 0.027), and the FIGO stage IIIC even more than FIGO stage IIIA (P = 0.013). Moreover, MVD was an independent predictor also of brief disease relapse (P = 0.001). Both MVD and VEGF were correlated with clinical response to chemotherapy (P = 0.01 and P = 0.037). Our data suggest that MVD and VEGF may have prognostic significance in advanced ovarian serous carcinoma.

Expression and clinical significance of CD31, CD34, and CD105 in pulmonary ground glass nodules with different vascular manifestations on CT

“…It not only regulates the early incidence of blood cell differentiation but also functions as a cell–cell adhesion factor in ECs and hematopoietic progenitor cells ( 37 ). CD31 is a platelet endothelial cell adhesion molecule (PECAM-1) expressed by lymphatic vessels and vascular ECs, which can assist with evaluating angiogenesis and EC motility ( 38 ). Both are commonly used markers of vascular ECs and play a significant part in the detection of tumor angiogenesis.…”

Paclitaxel With and Without Pazopanib for Persistent or Recurrent Ovarian Cancer

“…[5][6][7][8] Multiple reports have shown that angiogenesis is associated with worse survival for patients with ovarian cancer. [9][10][11][12][13] Bevacizumab, a monoclonal antibody that targets vascular endothelial growth factor (VEGF), gained U.S. Food and Drug Administration approval based on the results of the AURELIA (Avastin Use in Platinum-Resistant Epithelial Ovarian Cancer) trial, 4 in which bevacizumab in combination with chemotherapy improved progression-free survival (PFS) by 3.3 months compared with chemotherapy alone in women with platinum-resistant ovarian cancer following 1 to 2 prior regimens. 14 Pazopanib is an oral multitarget tyrosine kinase inhibitor of VEGF receptors 1, 2, and 3; platelet-derived growth factor (PDGF) receptors α and β; and proto-oncogene receptor tyrosine kinase (c-KIT).…”