Prognostic Significance of Microvessel Count in Low Stage Renal Cell Carcinoma

Yoshino, Shuji; Kato, Mikio; Okada, Koichi

doi:10.1111/j.1442-2042.1995.tb00445.x

Cited by 86 publications

(54 citation statements)

References 16 publications

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“…In contrast, other reports have shown that MVD is a better predictor for the metachronous metastasis of RCC than many other factors. 54 In support of these reports, we have shown that MVD is significantly higher in the primary tumor of patients with metastatic CRCC compared with patients with nonmetastatic CRCC. Furthermore, MVD is higher in the tumor metachronously metastasized than in the primary tumor of patients with metastatic CRCC.…”

Section: Discussionsupporting

confidence: 78%

Levels of angiogenesis and expression of angiogenesis‐related genes are prognostic for organ‐specific metastasis of renal cell carcinoma

Fukata

Inoue

Kamada

et al. 2005

Cancer

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Section: Discussionsupporting

confidence: 78%

Levels of angiogenesis and expression of angiogenesis‐related genes are prognostic for organ‐specific metastasis of renal cell carcinoma

Fukata

Inoue

Kamada

et al. 2005

Cancer

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“…As summarized in Table 1, higher MVD has been reported in many studies to be a favorable prognostic factor (eg, a higher blood vessel density in CCRCC is correlated with a better prognosis or longer patient survival). 4,[14][15][16][17][18][19][20][21][22] However, other studies have reported opposite results correlating higher MVD with poorer prognosis, [23][24][25][26][27][28] whereas others have been unable to find a significant prognostic role for MVD. [29][30][31][32][33] The controversy could result from many nonmechanistic factors, including sample size, sampling bias, the different blood vessel markers chosen for immunohistochemical (IHC) characterization, the quality of IHC staining, the methods of vasculature quantification, and the methods of interpretation.…”

Section: Differential Analysis Of Tumor Vasculaturementioning

confidence: 55%

Complexity of tumor vasculature in clear cell renal cell carcinoma

Qian

Huang

Wondergem

et al. 2009

Cancer

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Clear cell renal cell carcinoma (CCRCC) is a highly vascularized cancer resistant to conventional chemotherapy and radiotherapy. Antiangiogenic therapy has achieved some effectiveness against this unique malignancy. The complexity of the tumor vasculature in CCRCC has led to differences in correlating tumor microvessel density with patient prognosis. The authors' recent findings demonstrated that there were at least 2 major categories of tumor vessels in CCRCC-namely, undifferentiated and differentiated-correlating with patient prognosis in contrasting ways, with higher undifferentiated vessel density indicating poorer prognosis, and higher differentiated vessel density correlating with better prognosis. Furthermore, the presence of pericytes supporting the differentiated vessels varied in CCRCC. The distributions of pericyte coverage and differentiated vessels in CCRCC were uneven. The tumor margin had a higher pericyte coverage rate for differentiated vessels than did the inner tumor area. The uneven distributions of pericyte coverage and differentiated vessels in CCRCC prompted the authors to revisit the mechanism of tumor central necrosis, which was also known to be a prognostic indicator for CCRCC. The discrepancy of prognostic correlation between protein and messenger RNA levels of vascular endothelial growth factor in CCRCC was discussed. The complexity of the tumor vasculature in CCRCC also led the authors to begin to re-evaluate the therapeutic effects of antiangiogenic agents for each type of tumor vessel, which will in turn significantly broaden understanding of tumor angiogenesis and improve therapeutic effect. Clear cell renal cell carcinoma (CCRCC) is a highly vascularized malignancy. As evaluated by 2-phase multidetector computed tomography angiography, CCRCC is found to be able to develop an aberrant capsular vascular supply with outflow through an ovarian vein or testicular vein, 1 although positron emission tomography shows that blood perfusion of the tumor is reduced compared with normal kidney tissues. 2 Our expression profiling study also indicated that the expression level of vascular endothelial growth factor (VEGF; a potent proangiogenesis factor) in CCRCC is 5-fold higher than in other types of kidney

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“…Even though all the patients at the time There are numerous studies in the literature showing that MVD correlates with aggressive tumor behavior, as measured by decreased patient survival, increase incidence of metastasis, and higher stage at presentation. Weidner and colleagues first showed this relationship in patients with breast carcinoma [3], with MVD further shown to be a predictor of aggressive tumor behavior in patients with head-and-neck squamous cell carcinoma, non-small-cell lung carcinoma, cholangiocarcinoma, transitional cell carcinoma of the bladder, renal cell carcinoma, prostate carcinoma, ovarian carcinoma, and cervical squamous cell carcinoma [6][7][8][9][10][11][12][13][14]. MVD has also been previously explored in cutaneous malignant melanoma with some studies showing them to have significantly higher MVD counts then benign nevi [15,16].…”

Section: Discussionmentioning

confidence: 99%

Lack of Correlation Between Microvascular Density and Pathological Features and Outcomes in Sinonasal and Oral Mucosal Melanomas

Kerr

Wang

Lewis³

et al. 2011

Head and Neck Pathol

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Unlike its cutaneous counterpart, prognostic markers for primary mucosal malignant melanoma have not been well elucidated. It has been recently demonstrated that microvascular density (MVD) in cutaneous malignant melanoma has a significant negative correlation with survival; however, this has not been well-studied in mucosal malignant melanoma of the head and neck. This study explores the potential association between MVD, various histological parameters, and the outcome of a series of sinonasal and oral mucosal melanomas. Nineteen such cases were immunostained with CD31 and the MVD was calculated by using Bioquant Image Analysis Software (R and M Biometrics, Nashville, TN). These cases included 16 sinonasal and 3 oral cavity tumors. The 1, 2, 3, 4 and 5 years overall survival rates were 75, 57, 61, 46 and 46%, respectively. The MVD of the tumors ranged from 25.7 to 732 vessels/mm 2 (mean 142.8 vessels/mm 2 ; median 84.7 vessels/mm 2 ). There was no significant correlation between the MVD and the different clinicopathological features seen within the tumors. There was also no correlation between the MVD and relapse free and overall survival. The results of this study suggest that MVD does not correlate with outcome in mucosal melanoma of the head and neck as seen in cutaneous melanomas. Further larger studies are needed to identify predictive and prognostic markers in such melanomas.

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Prognostic Significance of Microvessel Count in Low Stage Renal Cell Carcinoma

Abstract: Assessment of tumor microvasculature is therefore probably one of the most important prognostic predictors in renal cell carcinoma.

Cited by 86 publications

References 16 publications

Levels of angiogenesis and expression of angiogenesis‐related genes are prognostic for organ‐specific metastasis of renal cell carcinoma

Levels of angiogenesis and expression of angiogenesis‐related genes are prognostic for organ‐specific metastasis of renal cell carcinoma

Complexity of tumor vasculature in clear cell renal cell carcinoma

Lack of Correlation Between Microvascular Density and Pathological Features and Outcomes in Sinonasal and Oral Mucosal Melanomas

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