Prognostic significance of microvascular counts in rectal carcinoma

Galindo‐Gallego, M.; Fernández-Aceñero, M. Jesús; Sanz-Ortega, Julián; Al‐Jam'a, Ali H.; López-Elzaurdia, C.

doi:10.1016/s0344-0338(00)80002-3

Cited by 15 publications

(10 citation statements)

References 18 publications

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“…One study was written in Chinese language, with an English abstract and did not seem to mention survival data (Liu et al, 1999). Some publications corresponded to duplicate studies of the same marker, six for MVD Abdalla et al, 1999;Galindo-Gallego et al, 2000;Furudoi et al, 2002;Kaio et al, 2003b;Onogawa et al, 2004) and four for VEGF expression Furudoi et al, 2002;Kaio et al, 2003b;Onogawa et al, 2004) (Figure 1). Almost all studies (n ¼ 40) used Dukes staging or derived classification (Astler-Coller).…”

Section: Resultsmentioning

confidence: 99%

Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature

et al. 2006

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We performed a meta-analysis of all published studies relating intratumoural microvessel density (MVD) (45 studies) or vascular endothelial growth factor (VEGF) expression (27 studies), both reflecting angiogenesis, to relapse free (RFS) and overall survival (OS) in colorectal cancer (CRC). For each study, MVD impact was measured by risk ratio between the two survival distributions with median MVD as cutoff. Eleven studies did not mention survival data or fit inclusion criteria, six were multiple publications of same series, leaving 32 independent studies for MVD (3496 patients) and 18 for VEGF (2050 patients). Microvessel density was assessed by immunohistochemistry, using antibodies against factor VIII (16 studies), CD31 (10 studies) or CD34 (seven studies). Vascular endothelial growth factor expression was mostly assessed by immunohistochemistry. Statistics were performed for MVD in 22 studies (the others lacking survival statistics) including nine studies (n ¼ 957) for RFS and 18 for OS (n ¼ 2383) and for VEGF in 17 studies, including nine studies for RFS (n ¼ 1064) and 10 for OS (n ¼ 1301). High MVD significantly predicted poor RFS (RR ¼ 2.32 95% CI: 1.39 -3.90; Po0.001) and OS (RR ¼ 1.44; 95% CI: 1.08 -1.92; P ¼ 0.01). Using CD31 or CD34, MVD was inversely related to survival, whereas it was not using factor VIII. Vascular endothelial growth factor expression significantly predicted poor RFS (RR ¼ 2.84; 95% CI: 1.95 -4.16) and OS (RR ¼ 1.65; 95% CI: 1.27 -2.14). To strengthen our findings, future prospective studies should explore the relation between MVD or VEGF expression and survival or response to therapy (e.g. antiangiogenic therapy). Assessment of these angiogenic markers should be better standardised in future studies.

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Section: Resultsmentioning

confidence: 99%

Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature

et al. 2006

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“…3,10,[14][15][16][17][18][19][20][21][22] Microvessel density (MVD) is considered a measure of angiogenesis and a strong prognosticator in patients with CRC. [23][24][25] We also have reported that angiogenesis plays an important role in metastasis and that MVD correlates significantly with LN metastasis of submucosal CRC. 15 Recently, it has been reported that lymphangiogenesis is an important factor in the metastasis of various cancers and that lymphatic vessel density (LVD) is significantly related to LN metastasis of some malignancies.…”

mentioning

confidence: 76%

Lymphatic Vessel Density at the Site of Deepest Penetration as a Predictor of Lymph Node Metastasis in Submucosal Colorectal Cancer

Kaneko

Tanaka

Oka

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…Tumour vascularization can be also examined immunohistochemically using CD34 antibody to determine the microvessel density (MVD). The grade of MVD in tumours is considered to be a measure of angiogenesis and a strong prognosticator in patients with a variety of cancers [20].…”

Section: Introductionmentioning

confidence: 99%

Association Between Thrombospondin-1, Angiogenesis Related Markers, and Extracellular Matrix Components with Colorectal Cancer Outcome

Mitselou¹,

Arvanitis²,

Skoufi³

et al. 2013

TOCOLCJ

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Abstract:Background: Angiogenesis is a multistep process that depends on the balance of proangiogenic factors and inhibitors as well as on interactions with the extracellular matrix. Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by THBS1 gene, whose promoter is activated by p53. Aim:To evaluate the relevance of TSP-1 in patients with colorectal cancer. Material and Methods:We examined the immunohistochemical expression of angiogenic agents (VEGF and CD34), proliferation associated indices, extracellular matrix components (tenascin, fibronectin, laminin, and collagen type IV), and the antiangiogenic agent TPS-1 in 97 patients with colorectal carcinoma (CRC) and correlated their expression levels with clinicopathological parameters.Results: TSP-1 was detected in the tumor cells, stroma and perivascular tissue. High and moderate tumor TSP-1 expression was observed in 24.75%, weak in 19.6%, while 55.7% of the cases were negative. High stromal expression was observed in 40.2% and perivascular stain was noted in 31.95% of the cases. Stromal TSP-1 expression was correlated with tumor type and tumor grade (p=0.001, and p=0.041 respectively) and with ECM components expression: tenascin (p=0.053), fibronectin (p=0.063), collagen type IV (p=0.004) and laminin (p=0.0001). The relationship of TSP-1 expression with tumor angiogenesis, growth fraction, p53 protein expression, and overall survival was not significant. Conclusions:Our data suggest that both tumor and stromal TSP-1 expression may not be a direct antiangiogenic factor, although it seems to be implicated in the remodeling of colorectal cancer tissue through interaction with other extracellular matrix components.

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Prognostic significance of microvascular counts in rectal carcinoma

Cited by 15 publications

References 18 publications

Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature

Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature

Lymphatic Vessel Density at the Site of Deepest Penetration as a Predictor of Lymph Node Metastasis in Submucosal Colorectal Cancer

Association Between Thrombospondin-1, Angiogenesis Related Markers, and Extracellular Matrix Components with Colorectal Cancer Outcome

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