Prognostic Significance of microRNA-221/222 Expression in Cancers: Evidence from 1,204 Subjects

Jin, Wang; Li, Sha; Sun, Guifang; Wang, Fang; Zou, Yan; Yang, Jing; Ning, Jie; Xu, Jing

doi:10.5301/jbm.5000058

Cited by 9 publications

(9 citation statements)

References 51 publications

(197 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently published studies show that miR-221 is an oncogenic microRNA involved in several malignancies (30,31). We found higher miR-221 expression in tumor samples in comparison to adjacent noncancerous tissue.…”

Section: Patients Below Patients Abovesupporting

confidence: 50%

Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy

Šmíd

Kulda

Srbecka

et al. 2016

International Journal of Oncology

View full text Add to dashboard Cite

Abstract.MicroRNAs have the potential to become valuable predictive markers for gastric cancer. Samples of biopsy tissue, routinely taken from gastric cancer patients undergoing palliative chemotherapy, constitute suitable material for microRNA profiling with the aim of predicting the effect of chemotherapy. Our study group consisted of 54 patients, all of whom underwent palliative chemotherapy based on 5-fluorouracil (5-FU) or 5-FU in combination with platinum derivatives between 2000 and 2013. The expression of 29 selected microRNAs and genes BRCA1, ERCC1, RRM1 and TS, in gastric cancer tissue macrodissected from FFPE tissue samples, was measured by quantitative RT-PCR. The relationship between gene expression levels and time to progression (TTP) and overall survival (OS) was analysed. From the set of the 29 microRNAs of interest, we found high expression of miR-150, miR-342-3p, miR-181b, miR-221, miR-224 and low levels of miR-520h relate to shorter TTP. High levels of miR-150, miR-192, miR-224, miR-375 and miR-342-3p related to shorter OS. In routinely available FFPE tissue samples, we found 6 miRNAs with a relation to TTP, which may serve as predictors of the effectiveness of palliative treatment in gastric cancer patients. These miRNAs could also help in deciding whether to indicate palliative chemotherapy.

show abstract

Section: Patients Below Patients Abovesupporting

confidence: 50%

Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy

Šmíd

Kulda

Srbecka

et al. 2016

International Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…In the first meta-analysis of miR-222 related to the outcomes of various cancers, Wang et al retrieved 4 studies and found that high miR-222 expression is negatively correlated with the clinical outcome, with a pooled HR of 2.15 [49]. Nevertheless, the relatively small study size limited the power of the results.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of miR-222 in Various Cancers: a Systematic Review and Meta-Analysis

Wei¹,

Ye²,

Peng³

et al. 2016

Clin. Lab.

View full text Add to dashboard Cite

show abstract

“…Meta-analysis is capable to obtain relatively accurate estimation by integrating all available evidence to explore authentic and comprehensive results. 11 The only meta-analysis regarding the prognostic value of miRNA-221/222 cluster in cancers was published in 2013 by Wang et al 12 Thus, we carried out an updated meta-analysis with larger sample size, more cancer types, more ethnicities, and different analysis models to verify the previous conclusions and especially uncover some novel findings, which may contribute to the exploration of new promising biomarkers for assessing the therapeutic efficacy and prognostic value of different types of cancers.…”

Section: Introductionmentioning

confidence: 99%

The correlation between microRNA-221/222 cluster overexpression and malignancy: an updated meta-analysis including 2693 patients

Zhang

Han

et al. 2018

CMAR

View full text Add to dashboard Cite

BackgroundAlthough miR-221/222 cluster plays an important role in many human malignancies, the correlation between miR-221/222 cluster overexpression and tumor prognosis remains controversial. Therefore, an updated meta-analysis was conducted to clarify its prognostic value in malignancy.MethodsWe conducted a search of literature in English electronic databases of PubMed, Embase, and Cochrane Library, and Chinese electronic databases of China Biology Medicine disc and China National Knowledge Infrastructure to obtain appropriate studies. Besides, we extracted hazard ratios (HRs) and 95% CIs to evaluate the strength of the correlations. In addition, the results of different subgroups analyses and publication bias test were also shown in this article.Results32 publications, including 15 tumor types and 2,693 patients were embraced in this meta-analysis. The results of univariate (HR =1.69, 95% CI: 1.18–2.44, P<0.01) and multivariate (HR =2.10, 95% CI: 1.63–2.69, P<0.01) analyses revealed that miR-221/222 cluster high expression in various tumors was significantly associated with adverse overall survival (OS). Correspondingly, we also found subgroups analyses consisted of country, miR-221/222 cluster component, sample size, and test method have similar results.ConclusionmiR-221/222 cluster overexpression was closely related to adverse OS in human carcinoma, while overexpression of miRNA-221/222 cluster could be viewed as a protection factor in prostate cancer. Blood-derived miR-221/222 cluster was not proper to assess OS.

show abstract

Prognostic Significance of microRNA-221/222 Expression in Cancers: Evidence from 1,204 Subjects

Cited by 9 publications

References 51 publications

Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy

Tissue microRNAs as predictive markers for gastric cancer patients undergoing palliative chemotherapy

Prognostic Value of miR-222 in Various Cancers: a Systematic Review and Meta-Analysis

The correlation between microRNA-221/222 cluster overexpression and malignancy: an updated meta-analysis including 2693 patients

Contact Info

Product

Resources

About