Prognostic significance of metastatic lymph node ratio in patients with gastric cancer after curative gastrectomy: a single-center retrospective study

He, Zhipeng; Li, Dongchang; Xu, Yunfeng; Wang, Haoran; Gao, Jian; Zhang, Zhigong; Chen, Ke

doi:10.1080/00365521.2022.2036807

Cited by 7 publications

(2 citation statements)

References 31 publications

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“…A similar large-volume study carried out in China evaluated 3864 GC patients. This study revealed that metastatic lymph node ratio (MLNR) may be a new indicator to assess the prognosis of GC patients undergoing curative gastrectomy [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of metastatic lymph node ratio in gastric cancer: a Western-center analysis

Ergenç,

Uprak,

Akın

et al. 2023

BMC Surg

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Background Tumor-node-metastasis (TNM) staging is the central gastric cancer (GC) staging system, but it has some disadvantages. However, the lymph node ratio (LNR) can be used regardless of the type of lymphadenectomy and is considered an important prognostic factor. This study aimed to evaluate the relationship between LNR and survival in patients who underwent curative GC surgery. Methods All patients who underwent radical gastric surgery between January 2014 and June 2022 were retrospectively evaluated. Clinicopathological features of tumors, TNM stage, and survival rates were analyzed. LNR was defined as the ratio between metastatic lymph nodes and total lymph nodes removed. The LNR groups were classified as follows: LNR0 = 0, 0.01 < LNR1 ≤ 0.1, 0.1 < LNR2 ≤ 0.25 and LNR3 > 0.25. Tumor characteristics and overall survival (OS) of the patients were compared between LNR groups. Results After exclusion, 333 patients were analyzed. The mean age was 62 ± 14 years. According to the LNR classification, no difference was found between groups regarding age and sex. However, TNM stage III disease was significantly more common in LNR3 patients. Most patients (43.2%, n = 144) were in the LNR3 group. In terms of tumor characteristics (lymphatic, vascular, and perineural invasion), the LNR3 group had significantly poorer prognostic factors. The Cox regression model defined LNR3, TNM stage II—III disease, and advanced age as independent risk factors for survival. Patients with LNR3 demonstrated the lowest 5-year OS rate (35.7%) (estimated mean survival was 30 ± 1.9 months) compared to LNR 0–1–2. Conclusion Our study showed that a high LNR was significantly associated with poor OS in patients who underwent curative gastrectomy. LNR can be used as an independent prognostic predictor in GC patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of metastatic lymph node ratio in gastric cancer: a Western-center analysis

Ergenç,

Uprak,

Akın

et al. 2023

BMC Surg

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“…On the other hand, PLR seems to be an integrated parameter able to monitor both thrombotic and inflammatory pathways [ 64 ]. Historically, it has been used as inflammatory biomarker in cancer patients [ 65 , 66 ], and a possible role has only recently identified as a predictor for CV events [ 67 ]. Finally, in a human study conducted on 199 patients that underwent coronary angiography, LMR was associated directly and independently with the severity of coronary atherosclerosis [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease

et al. 2022

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The high mortality related to chronic kidney disease (CKD) is not only due to the disease itself; in fact, CKD also represents an important risk factor for cardiovascular (CV) morbidity and mortality. Among the functional foods that seems to have cardioprotective action, extra virgin olive oil (EVOO) plays a pivotal health-promoting role. The aim of this study was to evaluate the possible cardioprotective effects of an EVOO containing a very high content (>900 ppm) of minor phenolic compounds (MPCs). The selected EVOO was analyzed by HPLC-DAD-MS to establish the MPC content. The Olea extract obtained from the selected EVOO was tested against the RAW 264.7 cell line in order to investigate its anti-inflammatory activity. We enrolled 40 CKD patients under conservative therapy for in vivo clinical testing. All CKD patients consumed 40 mL/day of raw EVOO for 9 weeks (T1). At baseline (T0) and at T1, we monitored the patients’ blood and urinary parameters. The patients’ body composition was assessed using bioelectrical impedance analysis and the carotid intima-media thickness (CIMT) using ultrasound imaging. At T1, we observed a decrease in inflammatory parameters, CIMT, and oxidative stress biomarkers. We also noticed improvements in lipid and purine metabolism, atherogenic indices, and body composition. Thus, this study highlighted the cardioprotective action of EVOO in nephropathic patients.

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Revolutionizing T3-4N0-2M0 gastric cancer staging with an innovative pathologic N classification system

Yin,

Jin,

Pan

et al. 2024

Journal of Gastrointestinal Surgery

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Prognostic significance of metastatic lymph node ratio in patients with gastric cancer after curative gastrectomy: a single-center retrospective study

Cited by 7 publications

References 31 publications

Prognostic significance of metastatic lymph node ratio in gastric cancer: a Western-center analysis

Prognostic significance of metastatic lymph node ratio in gastric cancer: a Western-center analysis

Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease

Revolutionizing T3-4N0-2M0 gastric cancer staging with an innovative pathologic N classification system

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Prognostic significance of metastatic lymph node ratio in patients with gastric cancer after curative gastrectomy: a single-center retrospective study

Cited by 7 publications

References 31 publications

Prognostic significance of metastatic lymph node ratio in gastric cancer: ﻿a Western-center analysis

Prognostic significance of metastatic lymph node ratio in gastric cancer: ﻿a Western-center analysis

Extra Virgin Olive Oil and Cardiovascular Protection in Chronic Kidney Disease

Revolutionizing T3-4N0-2M0 gastric cancer staging with an innovative pathologic N classification system

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Product

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Prognostic significance of metastatic lymph node ratio in gastric cancer: a Western-center analysis

Prognostic significance of metastatic lymph node ratio in gastric cancer: a Western-center analysis