Prognostic Significance of Metabolic Tumor Volume Measured by 18F-FDG PET/CT in Operable Primary Breast Cancer

Abstract

PET indices seem to be useful in the preoperative evaluation of prognosis in patients with operable primary breast cancer. NSUV, NMTV and TMTV might be considerable factors associated with patient outcome in operable breast cancer.

Tumor Heterogeneity Assessed by 18F-FDG PET/CT Is Not Significantly Associated with Nodal Metastasis in Breast Cancer Patients

“…PET/CT is also useful in evaluating treatment response and recurrence [2]. Parameters of 18F-FDG PET/CT, including maximum standardized uptake value (SUV max ) and metabolic tumor volume (MTV), are considered to be prognostic factors for survival and predictors of treatment response [3,4,5,6,7]. Tumor heterogeneity measured by 18F-FDG PET/CT has been emphasized in various malignancies.…”

Could semiquantitative FDG analysis add information to the prognosis in patients with stage II/III breast cancer undergoing neoadjuvant treatment?

“…Recently, Groheux et al [15] reported that TLG is superior to SUVmax as a predictor of outcome in patients with ER-positive/HER2-negative breast cancer. In addition, only one study has considered the role of MTV as a prognostic factor in breast cancer patients [6]. However, there are no studies that evaluated the correlation among WB semiquantitative PET/CT data, DFS and OS in patients with stage II/III breast cancer.…”

“…16 is a good predictor of disease progression and overall survival (OS). The usefulness of other measures, such as metabolic tumour volume (MTV) and total lesion glycolysis (TLG), for determining the aggressiveness of tumours and for predicting treatment response has been evaluated; however, although preliminary findings are encouraging, associations between these measures and prognosis have not been found consistently [6,7]. The aim of our study was to investigate whether SUVmax, MTV and TLG, and whole-body (WB) SUVmax, WB MTV and WB TLG can be considered prognostic factors predicting disease-free survival (DFS) and OS in patients with stage II/III breast cancer.…”

“…In contrast to our study, Satoh et al considered a small inhomogeneous (stage I/II/III/IV) population of 24 patients at initial staging of disease. Moreover, Kim et al[6] considered a group of patients with LABC who underwent PET/CT with FDG before NAC. The authors calculated the SUVmax and MTVof the primary tumours and lymph nodes, and the sum of the highest MTV in both primary tumour and lymph nodes (called T MTV).…”

Risk stratification in patients with advanced‐stage breast cancer by pretreatment [18F]FDG PET/CT

“…Growing evidence suggests that MTV and TLG may have prognostic value in several solid tumors . However, the use of these volumetric metabolic parameters in the prognosis of BC remains limited and the results are somewhat controversial, and criteria for these parameters have yet to be established …”