Prognostic significance of matrix metalloproteinase‐2, ‐8, ‐9, and ‐13 in oral tongue cancer

Mäkinen, Laura K.; Häyry, Valtteri; Atula, Timo; Haglund, Caj; Keski-Säntti, Harri; Leivo, Ilmo; Mäkitie, Antti; Passador-Santos, Fabrício; Böckelman, Camilla; Salo, Tuula; Sorsa, Timo; Hagström, Jaana

doi:10.1111/j.1600-0714.2011.01110.x

Cited by 47 publications

(57 citation statements)

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“…MMP8 levels, though elevated and previously suggested to play a protective role in tongue OSCC, 137 did not correlate with protection from tongue OSCC. 136 Similarly, there was no correlation between MMP2 and -9 levels with known clinicopathologic and/or prognostic variables. 136 On the other hand, the authors showed that high nuclear MMP13 expression was associated with increased invasion depth, tumor size, and poor survival in tongue OSCC.…”

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confidence: 94%

“…136 Similarly, there was no correlation between MMP2 and -9 levels with known clinicopathologic and/or prognostic variables. 136 On the other hand, the authors showed that high nuclear MMP13 expression was associated with increased invasion depth, tumor size, and poor survival in tongue OSCC. 136 The authors thus suggested that elevated serum levels of MMP13 may serve as a tumor biomarker in HNSCC.…”

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confidence: 94%

“…136 On the other hand, the authors showed that high nuclear MMP13 expression was associated with increased invasion depth, tumor size, and poor survival in tongue OSCC. 136 The authors thus suggested that elevated serum levels of MMP13 may serve as a tumor biomarker in HNSCC. 136 In contrast, MMP13 was not shown to correlate with tumor recurrence in HNSCC cases.…”

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confidence: 99%

“…136 The authors thus suggested that elevated serum levels of MMP13 may serve as a tumor biomarker in HNSCC. 136 In contrast, MMP13 was not shown to correlate with tumor recurrence in HNSCC cases. 138 In summary, there is accumulating evidence that specific MMPs can serve as potential prognostic markers in HNSCC.…”

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confidence: 99%

“…Mäkinen et al 136 investigated the potential prognostic values of MMP2, -8, -9, and -13 in OSCC of the tongue. MMP8 levels, though elevated and previously suggested to play a protective role in tongue OSCC, 137 did not correlate with protection from tongue OSCC.…”

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confidence: 99%

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Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases encoded by 24 distinct genes. Their functions have been implicated in numerous normal and pathologic processes, including uterine involution and organogenesis, inflammation and wound healing, vascular and autoimmune disease progression. Pertinent to this review, the role of MMPs in cancer biology is fairly well researched and documented, and remains a subject of continuing intense investigation. Not only are several MMPs overexpressed in head and neck squamous cell carcinomas (HNSCCs), expression has been correlated with salient tumorigenic hallmarks, such as cell proliferation, angiogenesis, invasion, and metastasis. The utility of changes in the expression profile, as well as various MMP polymorphisms as potential prognostic markers in oral cancers and oral premalignant lesions, have been investigated. Furthermore, the potential therapeutic utility of targeting MMPs in cancer remains attractive, although outcomes in this respect appear so far to be less encouraging with respect to HNSCCs. Because of the disappointing results observed in clinical trials where MMP-targeting regimens for HNSCCs utilized broad-spectrum small MMP catalytic site inhibitors, investigators now envision new strategies for MMP-specific targeting based on the recognition of new noncatalytic MMP domains with distinct functions. This review provides an overview of MMP activities in general and in cancers, and an update of their activities in HNSCC. Specifically, their role in the development and progression of HNSCC and their function as signaling molecules is discussed. Finally, their role as potential prognostic biomarkers and therapeutic targets in HNSCC is revisited.

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confidence: 94%

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confidence: 94%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Matrix metalloproteinases in head and neck cancer: current perspectives

Gkouveris¹,

Nikitakis²,

Aseervatham³

et al. 2017

MNM

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Changing trends in the management of the neck in oropharyngeal squamous cell carcinoma

et al. 2017

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Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta‐analysis

2019

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Background: The aim of this systematic review (SR) was to summarize and critically appraise available evidence on the association of the immunohistochemical expression of matrix metalloproteinases (MMPs) with the occurrence of lymph node/distant metastasis of oral squamous cell carcinoma (OSCC).Methods: Searches were conducted in five main electronic and three gray literature databases.Results: From 2128 records identified, 50 were included for qualitative analysis. A total of 12 MMPs were identified (--26, and MT1-MMP). Most included studies reported a positive association of MMP-1, -2, -3, -7, -9, and MT1-MMP with lymph node metastasis. MMP-8, -25, and -26 were not associated with lymph node metastasis.Conclusions: According to this SR, MMP-1, -2, -3, -7, -9, and MT1-MMP seem to play an important role in lymph node metastasis of OSCC. K E Y W O R D Simmunohistochemistry, lymphatic metastasis, matrix metalloproteinases, mouth neoplasms, neoplasm metastasis, systematic review

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Prognostic significance of matrix metalloproteinase‐2, ‐8, ‐9, and ‐13 in oral tongue cancer

Abstract: Our results suggest that especially MMP-13 may be regarded as a prognostic biomarker in OTSCC.

Cited by 47 publications

References 47 publications

Matrix metalloproteinases in head and neck cancer: current perspectives

Matrix metalloproteinases in head and neck cancer: current perspectives

Changing trends in the management of the neck in oropharyngeal squamous cell carcinoma

Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta‐analysis

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