Prognostic significance of marital status in breast cancer survival: A population-based study

Martı́nez, Marı́a Elena; Unkart, Jonathan T.; Li, Tao; Kroenke, Candyce H.; Schwab, Richard B.; Komenaka, Ian K.; Gomez, Scarlett Lin

doi:10.1371/journal.pone.0175515

Cited by 81 publications

(69 citation statements)

References 45 publications

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“…Another result of the present study is that marital status does not correlate with patients' quality of life either during chemotherapy or two years after the end of chemotherapy. This result seems to be inconsistent with previous studies as the majority of them indicate that unmarried women have a lower quality of life in comparison to married women (Martínez et al, 2017).…”

Section: Discussioncontrasting

confidence: 98%

“…Indeed, studies have shown that younger women are affected more in their long-term social, economic, psychological, and mental health well-being than older women (Engel et al, 2003;Sammarco, 2009). Furthermore, the younger and the unmarried women were positively associated with poorer mental well-being and more severe depressive symptoms (Martínez et al, 2017). Additionally, Rustøen, and Schjølberg (2000) reported that the work situation is the most important factor that affects the well-being of the older age group.…”

Section: Introductionmentioning

confidence: 99%

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Social support and quality of life in Greek women with breast cancer during chemotherapy and two years later

Goula¹,

Alikari²,

Charalampous³

et al. 2020

Health Psychology Report

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health psychology report • volume 8(2),  original article background Social support in women with breast cancer is associated with quality of life (QoL) and it appears to be vital for treating breast cancer and adaptation to disease. Social support seems to decrease quantitatively and over time while significant improvement in the patients' long-term emotional and physical function is observed. Therefore, the aim of this study was to investigate the differences in levels of social support and QoL in two independent groups of patients: women with breast cancer (i) during chemotherapy and (ii) two years after the chemotherapy. participants and procedure In this cross-sectional study 74 women with breast cancer "during chemotherapy" (n = 41) and "two years after chemotherapy" (n = 33) completed the Greek version of Multidimensional Scale of Perceived Social Support (MSPSS) and the Greek version of the Missoula-VITAS Quality of Life Index (MVQoLI-15) to measure social support and QoL respectively. All statistical analyses were performed with SPSS 25 with significance set at p < .05. results The group "two years after chemotherapy" reported better QoL than the "during chemotherapy" group. There was no difference in perceived social support between the two groups. The higher the patients' age, the lower the QoL for the "during chemotherapy" group and the higher the social support for the "two years after chemotherapy" group. conclusions QoL improves over time, emphasizing the ability of women to manage difficult situations. Social support remains important in both periods.

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Section: Discussioncontrasting

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Social support and quality of life in Greek women with breast cancer during chemotherapy and two years later

Goula¹,

Alikari²,

Charalampous³

et al. 2020

Health Psychology Report

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“…Only those without a primary tumor may have the chance to develop an advanced stage with metastasis. For the same reason, married persons with type 2 CUPs originating in the skin, lung, and breast have a better prognosis than unmarried persons, and such results are in agreement with those of previous studies . However, compared with the corresponding T n N 0‐X M 1 group, patients with type 2 CUP originating from the ovary tend to be unmarried, which may be explained by the influence of the estrogen level…”

Section: Discussionsupporting

confidence: 90%

Metastases with definitive pathological diagnosis but no detectable primary tumor: A surveillance epidemiology and end results‐based study

Luan

Dong

et al. 2019

Cancer Medicine

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Background This study investigates the characteristics of a special type of cancer of unknown primary site (CUP, type 2), which is a metastasis of a definite pathological diagnosis without a detectable primary site. Patients and methods Patients diagnosed between 2004 and 2014 were identified from the Surveillance Epidemiology and End Results (SEER) database. The characteristics of type 2 CUP from different sources were analyzed. For each source of type 2 CUP, tumors of the corresponding TnN0‐XM1 stage were used as controls. Results A total of 8505 patients with type 2 CUP were included in this analysis. Type 2 CUP shows an increasing trend, while type 1 shows the opposite. Type 2 CUPs have significant differences with stage IV of the same pathological primary lesion. Many characteristics influenced the prognosis of type 2 CUP patients, including marital status, age, race, sex, registration time, lymph node metastasis, surgery, chemotherapy, and radiation. Conclusion Our study suggests that identifying the source of metastasis is the key to the selection of treatment and the determination of the prognosis for CUP.

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“…There are 2 main theories for the protective effect of being partnered on survival: 1) economic/financial support; and 2) social/emotional support . At least 2 studies of marital status and clinical outcomes among patients with cancer have failed to find an association between marital status, SES, and disease‐specific outcomes . Although the patients in the current study who resided in the highest tertile of area‐level SES were more likely to receive adjuvant chemotherapy, we did not find significant associations between area‐level SES and the receipt of multiagent therapy or the completion of therapy.…”

Section: Discussioncontrasting

confidence: 78%

Partnered status and receipt of guideline‐concordant adjuvant chemotherapy among patients with colon cancer

Veenstra

Hawley

McLeod

et al. 2019

Cancer

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Background Partnered status is an independent predictor of clinical outcomes, including overall survival, among patients with cancer. However, the mechanisms by which partnered status impacts survival are not fully understood and to the authors' knowledge the associations between partnered status and the specific attributes of chemotherapy have not been studied to date. Methods The current study was an observational study of patients with resected American Joint Committee on Cancer (AJCC) stage III colon cancer diagnosed from 2008 through 2015 and recruited from an academic cancer center and 2 large community oncology practices. Outcome measures were specific attributes of adjuvant chemotherapy. Partnered status (partnered vs unpartnered) was the primary independent variable. Bivariate comparisons between independent variables and the primary outcomes were performed. Associations between partnered status and the outcomes also were analyzed using multivariable generalized estimating equations using a logit link. Results Data were collected from 436 patients. Of these patients, approximately 65% were from community oncology practices. Approximately 62% were partnered (married or living with a partner), and approximately 86% received adjuvant chemotherapy. Among these individuals, 87% received multiagent chemotherapy and 65% completed 6 months of therapy. Partnered patients were found to have a higher odds of completing chemotherapy (odds ratio, 1.98; 95% CI, 1.04‐3.77). Conclusions In this innovative investigation of the associations between partnered status and specific attributes of curative‐intent chemotherapy, approximately 35% of patients terminated chemotherapy early. Having a partner increased the odds of completing therapy, which may be one mechanism through which having a partner improves disease‐specific outcomes among patients with colon cancer. Identifying those aspects of partner support that can be reproduced with community or clinical personnel may help unpartnered patients to complete the recommended course of curative‐intent chemotherapy.

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Prognostic significance of marital status in breast cancer survival: A population-based study

Cited by 81 publications

References 45 publications

Social support and quality of life in Greek women with breast cancer during chemotherapy and two years later

Social support and quality of life in Greek women with breast cancer during chemotherapy and two years later

Metastases with definitive pathological diagnosis but no detectable primary tumor: A surveillance epidemiology and end results‐based study

Partnered status and receipt of guideline‐concordant adjuvant chemotherapy among patients with colon cancer

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