Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations

Jiang, Hai; Zhang, Zhiyong; Wang, Xiaoyan; Tang, Xuan; Liu, Hailong; Wang, Aili; Li, Huaguang; Tang, Erjiang; Lin, Moubin

doi:10.3748/wjg.v25.i20.2489

Cited by 42 publications

(43 citation statements)

References 41 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been no studies on lymphovascular invasion of rectal cancer using radiomics. Lymphovascular invasion has been studied in breast (28); colorectal (29); and endometrial cancers (30); and urinary tract urothelial carcinoma (31). However, radiomics was only used in the lymphovascular invasion of breast cancer (32).…”

Section: Discussionmentioning

confidence: 99%

A Novel Multimodal Radiomics Model for Preoperative Prediction of Lymphovascular Invasion in Rectal Cancer

Zhang

Guo

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

Objective: To explore a new predictive model of lymphatic vascular infiltration (LVI) in rectal cancer based on magnetic resonance (MR) and computed tomography (CT). Methods: A retrospective study was conducted on 94 patients with histologically confirmed rectal cancer, they were randomly divided into training cohort (n = 65) and validation cohort (n = 29). All patients underwent MR and CT examination within 2 weeks before treatment. On each slice of the tumor, we delineated the volume of interest on T2-weighted imaging, diffusion weighted imaging, and enhanced CT images, respectively. A total of 1,188 radiological features were extracted from each patient. Then, we used the student t-test or Mann-Whitney U-test, Spearman's rank correlation and least absolute shrinkage and selection operator (LASSO) algorithm to select the strongest features to establish a single and multimodal logic model for predicting LVI. Receiver operating characteristic (ROC) curves and calibration curves were plotted to determine how well they explored LVI prediction performance in the training and validation cohorts. Results: An optimal multi-mode radiology nomogram for LVI estimation was established, which had significant predictive power in training (AUC, 0.884; 95% CI, 0.803-0.964) and validation (AUC, 0.876; 95% CI, 0.721-1.000). Calibration curve and decision curve analysis showed that the multimodal radiomics model provides greater clinical benefits. Conclusion: Multimodal (MR/CT) radiomics models can serve as an effective visual prognostic tool for predicting LVI in rectal cancer. It demonstrated great potential of preoperative prediction to improve treatment decisions.

show abstract

Section: Discussionmentioning

confidence: 99%

A Novel Multimodal Radiomics Model for Preoperative Prediction of Lymphovascular Invasion in Rectal Cancer

Zhang

Guo

et al. 2020

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 80%

Survival after Curative Resection for Stage I Colorectal Mucinous Adenocarcinoma

Huang

Luo

Lai

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…LVI is considered to be an early event in lymph node metastasis, and it has been proved to be an independent predictor of survival in CRC. The LVI group showed a higher risk of recurrence and a signi cantly lower overall survival rate in advanced CRC compared with the non-LVI group [25]. Meanwhile, LVI also has an independent predictor power for poor prognosis rectal cancer after neoadjuvant therapy and surgery [26].…”

Section: Discussionmentioning

confidence: 92%

Survival after Curative Resection for Stage I Colorectal Mucinous Adenocarcinoma

Huang

Luo

Lai

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The prognostic value of the mucinous adenocarcinoma histotype on the early stages especially for stage I colorectal cancer (CRC) is still unclear. This study determined the clinicopathologic characteristics and long-term outcome of stage I colorectal mucinous adenocarcinomas (MAC). Methods: Among the total of 503 patients with stage I CRC (56 having MAC and 447 having non-MAC) who underwent radical resection, the correlation between clinicopathological factors and MAC was analyzed. Multivariate analysis was performed to determine whether mucinous histotype itself was an independent prognostic impact in stage I patients. Results: MACs were observed more frequently located in the colon than rectum (p=0.046), more frequently displayed the microsatellite instability (MSI) phenotype (p=0.023) and had a greater frequency of T2 stage (p=0.001). The rate of recurrence was 13.5% and the cancer-specific mortality was 4.3% among all stage I CRC patients. There was no difference in disease-free survival and overall survival between MACs and non-MACs. On multivariate analysis, older age (p=0.030，hazard ratio: 2.62), rectal cancer (p=0.025, hazard ratio: 5.42), lymphovascular invasion (LVI) (p<0.001, hazard ratio: 9.74), and microsatellite stability (MSS) phenotypes (p=0.023, hazard ratio: 4.21) were independently associated to poor survival of stage I CRC. A high carcinoembryonic antigen (CEA) level (p=0.031, hazard ratio: 1.95), rectal cancer (p=0.045, hazard ratio: 1.64), LVI (p=0.002, hazard ratio: 3.95) and MSS phenotypes (p=0.012, hazard ratio: 2.98) were independently related to short disease-free survival of stage I CRC.Conclusions: Compared with non-MAC, MAC patients had more T2 patients and more MSI phenotypes in stage I CRC at presentation, but the mucinous histology is not a significant predictor of recurrence and prognosis in stage I CRC.

show abstract

Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations

Cited by 42 publications

References 41 publications

A Novel Multimodal Radiomics Model for Preoperative Prediction of Lymphovascular Invasion in Rectal Cancer

A Novel Multimodal Radiomics Model for Preoperative Prediction of Lymphovascular Invasion in Rectal Cancer

Survival after Curative Resection for Stage I Colorectal Mucinous Adenocarcinoma

Survival after Curative Resection for Stage I Colorectal Mucinous Adenocarcinoma

Contact Info

Product

Resources

About