Prognostic Significance of Left Atrial Size in Patients With Hypertrophic Cardiomyopathy (from the Italian Registry for Hypertrophic Cardiomyopathy)

Nistri, Stefano; Olivotto, Iacopo; Betocchi, Sandro; Losi, Maria Angela; Valsecchi, Grazia; Pinamonti, Bruno; Conte, Maria Rosa; Casazza, Franco; Galderisi, Maurizio; Maron, Barry J.; Cecchi, Fabiola

doi:10.1016/j.amjcard.2006.05.013

Cited by 202 publications

(121 citation statements)

References 24 publications

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“…Another option is, especially in obstructive types, the presence of mitral regurgitation due to the SAM. LA size also correlates with the severity of symptoms, the presence of atrial fi brillation, severity of LVOTG and especially with mortality, which was confi rmed by Nistri et al (27). In the context of LV remodeling after the ASA, simultaneously with LVOTG decrease and IVS thinning, a statistically signifi cant thinning of PW occurred in all reporting periods.…”

Section: Tab 2 Development Of Parameters In Both Groups (Comparisonmentioning

confidence: 55%

Conservative versus invasive treatment in hypertrophic obstructive cardiomyopathy: an echocardiography study

Honĕk¹,

Krejčí²,

Máchal³

et al. 2017

BLL

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AIM AND METHODS: The aim of our study was to compare the development of echocardiographic parameters and functional status of patients with hypertrophic obstructive cardiomyopathy (HOCM) treated conservatively (n = 41) or by alcohol septal ablation (ASA; n = 39). RESULTS: Left ventricular outfl ow tract gradient (LVOTG) decreased in the fi rst year by 53.7 ± 36.4 mmHg in ASA group versus 5.5±47.1 mmHg in conservatively treated group (p < 0.001), in the third year by 53.1 ± 41.4 mmHg versus 23.9±42.7 mmHg (p = NS) and in the fi fth year, the reduction of LVOTG was 52.1 ± 44.5 mmHg in ASA group and 3.0±63.2 mmHg in conservatively treated group (p < 0.05). Change in NYHA class in the fi rst year was -1.1±0.4 versus 0.1±0.5, in the third year -1.0±0.6 versus 0.1±0.4 and in the fi fth year -0.8 ± 0.5 versus 0.1±0.4 (all p<0.001). CONCLUSION: Our results showed for the fi rst time that decline of LVOTG after ASA creates a favorable left ventricle remodeling and leads to signifi cant improvement of functional status of HOCM patients in comparison with conservative treatment (Tab. 3, Fig. 2, Ref. 42). Text in PDF www.elis.sk.

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Section: Tab 2 Development Of Parameters In Both Groups (Comparisonmentioning

confidence: 55%

Conservative versus invasive treatment in hypertrophic obstructive cardiomyopathy: an echocardiography study

Honĕk¹,

Krejčí²,

Máchal³

et al. 2017

BLL

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“…По данным предыдущих исследований, такая форма встречается у 15-20 % пациентов с ГКМП [14,16,18]. При опреде-лении этой стадии прогрессирования заболевания каж-дая из характеристик, таких как наличие ФВ ЛЖ в низ-ком или нормальном диапазоне [14], изменение диасто-лической функции от умеренной до выраженной [19], выраженная дилатация ЛП [17], увеличение области отсроченного конрастирования гадолинием [19], истон-чение стенки ЛЖ [13], эпизоды ФП [20,21], спонтан-ное снижение или утрата градиента выходного тракта ОРИГИНАЛЬНЫЕ СТАТЬИ § ЛЖ [22], описывались отдельно в когортах пациентов с ГКМП. Однако эти характеристики имеют тенденцию «собираться или скапливаться» у отдельных индивиду-умов, являясь различными аспектами прогрессирования заболевания у одной и той же подгруппы пациентов.…”

Section: Discussionunclassified

Clinical variants and outcomes of progressive chronic heart failure in individuals with hypertrphic cardiomyopathy

Комиссарова¹,

Zakharova²,

Iljina³

et al. 2017

RHFJ

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“…Other studies reported a close relationship between the severity of LV diastolic failure and LV hypertrophy [22,32] or left atrial size [33]. Furthermore, the left atrial volume [34] in patients with isolated diastolic failure and left atrial dimension [35] in patients with hypertrophic cardiomyopathy are considered to be important parameters for predicting prognosis.…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic Features of Patients With Congestive Heart Failure and Preserved Left Ventricular Pump Function: A Retrospective Study in a Selected Common Disease Cohort

et al. 2008

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IntroductionWith respect to the recent clinical issue of isolated left ventricular (LV) diastolic dysfunction, many studies have reported that 30% to 40% of patients with congestive heart failure (CHF) have preserved LV systolic function [1][2][3]. When pulmonary congestion, that is, an increase in left atrial pressure, is observed in such patients, the transmitral flow (TMF) velocity shows a pseudonormalized or restrictive pattern in many of the patients [4,5]. However, in clinical practice, the peak early diastolic TMF velocity (E) is lower than the peak atrial systolic TMF velocity (A) (E/A<1) in most patients with LV diastolic dysfunction, suggesting relaxation abnormalities. Therefore, it is difficult to predict whether isolated diastolic dysfunction will cause CHF in the future in individual patients with E/A<1. Douglas [6] indicated that the left atrial size reflects the history of LV diastolic dysfunction, and that the level of left atrial enlargement is associated with the serum HbA1c concentration in patients with diabetes. The development of ultrasonic strain imaging has facilitated the evaluation of regional myocardial systolic and diastolic function and is not influenced by whole heart motion or tethering [7]. In the present study, we divided patients, in whom LV pump function was maintained with TMF showing a relaxation abnor- AbstractBackground. Little is known of the pathophysiologic characteristics of a common disease cohort with congestive heart

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Prognostic Significance of Left Atrial Size in Patients With Hypertrophic Cardiomyopathy (from the Italian Registry for Hypertrophic Cardiomyopathy)

Cited by 202 publications

References 24 publications

Conservative versus invasive treatment in hypertrophic obstructive cardiomyopathy: an echocardiography study

Conservative versus invasive treatment in hypertrophic obstructive cardiomyopathy: an echocardiography study

Clinical variants and outcomes of progressive chronic heart failure in individuals with hypertrphic cardiomyopathy

Echocardiographic Features of Patients With Congestive Heart Failure and Preserved Left Ventricular Pump Function: A Retrospective Study in a Selected Common Disease Cohort

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