Prognostic Significance of Lateral Lymph Node Micrometastases in Lower Rectal Cancer

Shimoyama, Masaaki; Yamazaki, Toshiyuki; Suda, Takeyasu; Hatakeyama, Katsuyoshi

doi:10.1007/s10350-004-6552-y

Cited by 62 publications

(44 citation statements)

References 38 publications

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“…However, the subgroup of patients with positive LLN can survive for more than five years after PSD. The reported five-year survival rates of patients with positive LLN ranged from 37.3 to 49.3 percent in each institute study, 31,32,[36][37][38][39][40] and the present study, which included a large number of patients, also showed the rate of 45.8 percent (Table 6).…”

Section: Discussionsupporting

confidence: 52%

“…This could be explained by that PSD may remove micrometastasis, which is not detected by routine histopathologic examination. An immunohistochemical study by Shimoyama et al 39 revealed micrometastasis of LLN in 11 of 57 patients who had negative LLN in routine histopathologic examination.…”

Section: Discussionmentioning

confidence: 98%

“…Table 6 summarizes the studies of PSD and positive LLN reported since 1996. [36][37][38][39][40] All except two 31,32 analyzed. The greater incidence of positive LLN of lower rectal cancer was observed by Ueno et al 40 and in this study.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer

Sugihara¹,

Kobayashi²,

Kato³

et al. 2006

Diseases of the Colon &Amp; Rectum

387

287

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer

Sugihara¹,

Kobayashi²,

Kato³

et al. 2006

Diseases of the Colon &Amp; Rectum

387

287

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show abstract

“…In 6 studies out of 14 [14][15][16][17][18][19] micrometastasis was associated with poor prognosis compared to NND; one [26] found that it was correlated with other poor prognostic factors, and others [20][21][22][23][24][25] concluded that it did not influence patient prognosis.…”

Section: Resultsmentioning

confidence: 99%

Detection and prognostic impact of micrometastasis in colorectal cancer

Sirop

Kanaan

Korant

et al. 2011

Journal of Surgical Oncology

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Review of literature was performed on studies with prognostic impact of micrometastasis in colorectal cancer. Among 16 studies included, micrometastasis was detected in 26.5% of patients. Most analysis revealed that micrometastasis carries a poorer prognosis compared to node negative disease (NND). The results of those studies were compared with our pilot study of 109 patients with colon cancer, showing improved prognosis of micrometastasis after being upstaged and treated with chemotherapy when compared with NND.

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“…As noted above, the use of immunohistochemical studies to detect otherwise undetectable micrometastases has been employed in a variety of tumor types, ranging from breast cancer to colorectal carcinoma to gastric carcinoma to pancreatic carcinoma [30][31][32][33]. It seems clear that in each organ system examined (including cervical lymph nodes in patients with head and neck carcinomas), immunohistochemical detection of micrometastases exceeds the typical resolution of conventional light microscopy alone, that is, immunohistochemistry may be expected to yield a higher detection rate of metastatic disease than routine light microscopy.…”

mentioning

confidence: 99%

Immunohistochemical Studies in the Identification of Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Head and Neck

Rinaldo

Devaney

Ferlito

2004

ORL

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In the prediction of likely disease-free and overall survival intervals in patients with squamous carcinomas of the head and neck, cervical lymph node status assumes a prime role, and patients with cervical node metastases have diminished survivals, as a group, compared with patients whose cervical nodes are reported as negative for metastatic carcinoma. Conventional means of pathologic examination of cervical node biopsy specimens include examination of a single section through each individual node identified on gross examination, a process which, of necessity, leaves a significant portion of the node unexamined by microscopy. Recently, it has become apparent that more exhaustive pathologic sampling techniques, such as examining multiple sections of each lymph node, or staining each lymph node with antibodies to keratin via immunohistochemistry, will reliably yield a greater incidence of positive cervical lymph nodes (‘micrometastases’) than do conventional pathologic techniques. This suggests that the next line of inquiry should answer this question: just because micrometastases can be detected, should they be? Does the identification of (otherwise likely to be overlooked) tiny microscopic foci of spread of tumor in regional nodes by more sophisticated techniques yield additional data of real import to the patients, or is such information of lesser value? Should a role be defined in the care of head and neck cancer patients for the use of such advanced inquiries in the structuring of therapies, then the best approach to finding such elusive micrometastases (intraoperative immunohistochemistry? immunohistochemistry using routinely fixed tissues? polymerase chain reaction?) may subsequently be established.

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Prognostic Significance of Lateral Lymph Node Micrometastases in Lower Rectal Cancer

Cited by 62 publications

References 38 publications

Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer

Indication and Benefit of Pelvic Sidewall Dissection for Rectal Cancer

Detection and prognostic impact of micrometastasis in colorectal cancer

Immunohistochemical Studies in the Identification of Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Head and Neck

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