Prognostic significance of Ki-67 (MIB1), PCNA and p53 in cancer of the oropharynx and oral cavity

Sittel, Christian; Ruiz, S.; Volling, P.; Kvasnicka, H. M.; Jungehülsing, M.; Eckel, Hans Edmund

doi:10.1016/s1368-8375(99)00041-x

Cited by 82 publications

(67 citation statements)

References 29 publications

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“…2 In human cancers, accumulation of p53 has been shown to be a good indicator of poor prognosis. 10,13,20 In this study, we found p53 expression in 46% of the 140 tumors investigated, which is lower than the reported 64% 31 but similar to that 23,32 found in head and neck cancers, when examined using the same antibody and cutoff value. Our data, however, confirmed the results of previous studies that failed to establish an association of p53 expression with survival in head and neck cancers.…”

Section: Molecular Marker Expression In Oral Cancer M Shiraki Et Alsupporting

confidence: 55%

“…7 Apart from the well-established prognostic indicators of TNM staging and mode of invasion, these markers have high prognostic values in human cancer, [8][9][10][11][12][13][14][15][16][17][18][19][20][21] although there are some discrepancies. [22][23][24] In view of the prospective impact of multiple molecular marker accumulation on tumor progression, multiple-marker testing could provide us with more useful information for our definition of the biological behavior of oral cancer than single marker expression. However, p53, cyclin D1 and EGFR have never been analyzed together in a multiparametric approach for predicting outcome in head and neck cancers.…”

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confidence: 99%

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Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

et al. 2005

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p53, cyclin D1 and epidermal growth factor receptor (EGFR) are molecular markers that regulate the cell cycle or cell growth and play important roles in tumor development and progression. In this study, we examined the impact of immunohistochemical expression of these markers on tumor progression in 140 oral cancers. p53, cyclin D1 and EGFR were expressed in 64 cases (46%), 54 cases (39%) and 54 cases (39%), respectively, but there was no inter-relationship between any two of these markers. In the association of these markers with clinicopathological features, EGFR expression alone was significantly associated with poor differentiation (P ¼ 0.0008) and invasive growth pattern (P ¼ 0.0003). Any of these markers, including EGFR, had no significant impact on survival. Coexpression of all these markers, however, was significantly associated with invasive growth pattern (P ¼ 0.0149) and shortened survival (P ¼ 0.0181), and was a significant and independent unfavorable prognostic factor (P ¼ 0.0002), along with tumor size (P ¼ 0.0040), nodal metastasis (P ¼ 0.0137) and growth pattern (P ¼ 0.0017) in a multivariate analysis. Simultaneous coexpression of these markers in oral cancers might prove to be a useful indicator for identification of low-or high-risk patients.

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Section: Molecular Marker Expression In Oral Cancer M Shiraki Et Alsupporting

confidence: 55%

mentioning

confidence: 99%

Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

et al. 2005

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“…Several researches have focused on the significance of Ki-67 in squamous cell carcinoma of head and neck (Girod et al, 1998;Sittel et al, 1999;Stoll et al, 2000;Bettendorf and Herrmann, 2002;Carinci et al, 2002;Myoung et al, 2006). This heterogeneous result showed the correlation of Ki-67 expression to tumor phenotype factors.…”

Section: Discussionmentioning

confidence: 95%

G1/S-specific Cyclin-D1 Might be a Prognostic Biomarker for Patients with Laryngeal Squamous Cell Carcinoma

Zhang¹,

Xu²,

Wang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To investigate the prognostic role of antigen KI-67 (Ki-67) and G1/S-specific cyclin-D1 (cyclin-D1) in patients with laryngeal squamous cell carcinoma (LSCC). Methods: Immunohistochemical staining (IHS) was used to determine the protein expression of Ki-67 and cyclin-D1 in LSCC tissues. Kaplan-Meier survival curves was calculated with reference to Ki-67 and cyclin-D1 levels. Results: Cyclin-D1 and Ki67 were expressed in the nuclei of cancer cells. Among the total of 92 cancer tissues examined by immunohistochemistry, 60 (65.22%) had cyclin-D1 overexpression and 56 (60.87%) had Ki67 overexpression. Cyclin-D1 overexpression is associated with the advanced stage of the cancer (P=0.029), but not with gender, age, stage of cancer, histological differentiation, anatomical site, smoking history and alcohol consumption history. Ki67 overexpression is not associated with the advanced stage, gender, age, histological differentiation, anatomical site, smoking history and alcohol consumption history. A statistically significant correlation was found between lymph node status and the expression of Ki67 (p = 0.025). Overexpression of cyclin-D1 was correlated to shorter relapse-free survival period (P<0.001). Conclusions: Overexpression of cyclin-D1 can be used as a marker to predict relapse in patients with LSCC after primary curative resection.

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“…Essa proteína não está envolvida no sistema de reparação do DNA, e sua expressão restringe-se aos compartimentos proliferativos dos tecidos. Adicionalmente, o Ki-67 não sofre influências marcantes da fixação e do processamento histológicos ou da diluição do anticorpo (6,10,19,28,29) . Nossos resultados demonstraram que não houve diferença estatisticamente significativa entre os dois grupos analisados (p = 0,72), fato este também verificado por Donofrio et al (3) , que não encontraram correlação entre presença de HPV e índices aumentados de proliferação celular em lesões cancerizáveis (displasias leves, moderadas e severas) e OSCCs microinvasivos.…”

Section: Discussionunclassified

“…Porém, o real valor clínico dessa possível indicação de agressividade tumoral é ainda objeto de debate. É discutível, por exemplo, quando consideramos os protocolos terapêuticos dos diversos centros de tratamento, pois a resposta à radioterapia, por exemplo, é mais eficaz em tumores que exibem maiores índices de proliferação, o que não é verdadeiro para a cirurgia e é variável para a quimioterapia (6,19) .…”

Section: Discussionunclassified

Análise comparativa da proliferação celular entre carcinomas de células escamosas orais HPV-positivos e HPV-negativos

Rocha¹,

Souza²,

Pinto³

2007

J. Bras. Patol. Med. Lab.

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Introdução: O carcinoma de células escamosas oral (OSCC) representa a neoplasia maligna mais freqüente em boca, e, entre os agentes etiológicos implicados, o papilomavírus humano (HPV) tem sido extensivamente estudado nos últimos anos. Objetivo: Analisar comparativamente os índices de proliferação celular em OSCCs HPV-negativos e HPV-positivos. Material e método: A amostra consistiu em 11 casos de OSCCs HPV-positivos (10 infectados por HPV-18 e um por HPV-16 e 18) e 13 HPVnegativos, previamente analisados quanto à presença ou ausência, bem quanto à tipagem viral por proteína C reativa (PCR) (primers GP5+/GP6+) e hibridização dot blot, respectivamente. No método imunoistoquímico utilizou-se a técnica da estreptoavidina-biotina, com anticorpo para a proteína nuclear Ki-67. Resultados: O teste estatístico não-paramétrico de Mann-Whitney revelou que não houve diferença estatisticamente significativa entre os grupos HPV-positivo e HPV-negativo (p = 0,72). Discussão: Os estudos semelhantes a estes são poucos e não são concordantes em demonstrar maior atividade proliferativa tumoral nos casos HPV-positivos em relação aos HPV-negativos, seja através da análise da expressão de proteínas relacionadas ao ciclo celular, seja na análise direta da fração proliferativa tumoral. Conclusão: Não houve diferença no índice de proliferação celular entre os grupos de OSCCs HPV-positivo e HPV-negativos. abstract resumo Background: Oral Squamous Cell Carcinoma (OSCC) is the most common malignant tumor in the mouth, and the human papillomavirus (HPV) has been hardly studied as a possible etiologic agent. Objectives: The aim of this study was to compare the rates of cell proliferation in HPV-positive and HPV-negative OSCC, using the immunohistochemical antibody Ki-67. Material and method: The sample consisted of 11 cases HPV-positive OSCC (10 cases infected with HPV-18 and 1 case infected with HPV-16 and 18) and 13 cases HPV-negative OSCCs, previously analyzed regarding the presence or absence of HPV, as well as the viral type, using PCR (primers GP5+/GP6+) and dot blot hybridization, respectively. Immunohistochemical study was performed by streptoavidin-biotin technique with antibody against nuclear protein

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Prognostic significance of Ki-67 (MIB1), PCNA and p53 in cancer of the oropharynx and oral cavity

Cited by 82 publications

References 29 publications

Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

Combined expression of p53, cyclin D1 and epidermal growth factor receptor improves estimation of prognosis in curatively resected oral cancer

G1/S-specific Cyclin-D1 Might be a Prognostic Biomarker for Patients with Laryngeal Squamous Cell Carcinoma

Análise comparativa da proliferação celular entre carcinomas de células escamosas orais HPV-positivos e HPV-negativos

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