Acute right ventricular (RV) infarction sometimes accompanies precordial S-T elevation that mimicks
anterior left ventricular (LV) infarction. Thus, we compared and characterized the 12-lead electrocardiographic
(ECG) differences in the hyperacute stage between the two conditions. We studied two groups of patiens with first
acute myocardial infarction presenting with precordial S-T elevation, one of RV infarction (group A, n = 11) and the
other of anterior wall LV infarction (group B, n = 42). In the anterior precordial leads, S-T elevation of >5 mm was
present in up to 67% in group B, but in only 18% of group A (p < 0.01). The average mean number of leads with S-T
elevation was greater in group B (4.3 ± 1.1) than in group A (2.3 ± 1.4) (p < 0.01). The maximal S-T elevation was
frequently observed in lead V(1) in group A (55%) and in lead V(3) or V(4) in group B (64%). No group B patients had
maximal S-T elevation in lead Vi. In the inferior leads, S-T elevation occurred in 91% of group A patients, although
the degree was often not marked, but S-T elevation occurred in only 5% group B patients (p < 0.01). Contrary to
this, the incidence of S-T depression was greater in group B (60%) than in group A (9%) (p < 0.01). In lateral leads,
S-T elevation was only seen in group B patients (55%). S-T depression was observed more frequently in group A
(91%) than in group B patients (14%) (p < 0.01). Right axis deviation of ≥90° was observed more frequently in
group A (36%) than in group B (2%) (p < 0.01) and left anterior hemiblock or leftward frontal axis shift of ≤0° in
group B (31%). The incidence of RV conduction disturbance was higher in group A (45%) than in group B (9%) (p <
0.05). We conclude that systematic analysis of the 12-lead ECG recorded in hyperacute stage offers valuable information
to distinguish the two conditions.