Prognostic significance of influence of CD-31 and PDEF expression in patients with non-small-lung cancer

Emmert, Alexander; Didilis, Vassilios; Bohler, Aaron; Markus, Ján; Füzesi, L.; Waldmann-Beushausen, Regina; Bougioukas, Ioannis; Schöndube, Friedrich A.; Danner, B

doi:10.1055/s-0034-1367089

Cited by 2 publications

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“…The positive correlation between VEGF-A expression and adenocarcinoma was previously revealed in many studies [32][33][34][35]. On the other hand, other researchers could not come out with the same conclusion neither for CD31 [8,[35][36][37][38].…”

Section: Discussionmentioning

confidence: 87%

Expression Profiles of VEGF-A, CD31 and GRP78 in Non-Small Cell Lung Cancer.

Al-Keilani¹,

Alqudah²,

Almomani³

et al. 2020

Preprint

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BackgroundAngiogenesis is mandatory for tumor growth and progression. The modest response to the anti-angiogenic therapies in non-small cell lung cancer reflects the presence of confounding molecular factors. The aims of this study were to investigate the expression levels of VEGF-A, CD31 and GRP78 and test for significant correlations between them.MethodsParaffin-embedded NSCLC tissue samples (71 adenocarcinoma and 23 squamous cell carcinoma) were retrospectively collected from 94 patients who underwent surgical resection between 2008 and 2015; and did not receive chemotherapy or radiotherapy prior to surgery. The expressions of VEGF-A, CD31 and GRP78 were determined by immunohistochemistry. ResultsHigh expression levels of VEGF-A, CD31 and GRP78 were observed in 15, 36 and 74 cases, respectively. Adenocarcinomas expressed higher levels of the aforementioned proteins as compared with squamous cell carcinomas (p-value < 0.05). Moreover, a statistically significant association was found between VEGF-A and CD31 expression levels (p-value = 0.006).ConclusionsOur study was the first to investigate the associations between GRP78 and the angiogenesis markers CD31 and VEGF-A in NSCLC patients. High GRP78 expression was revealed in the majority of the investigated samples. Nevertheless, no relationship was found between GRP78 and VEGF-A or CD31 which could be attributed to small sample size. On the other hand, the positive association between VEGF-A and CD31 expression levels suggests that VEGF-A may cooperate with CD31 to promote angiogenesis in NSCLC.

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Section: Discussionmentioning

confidence: 87%

Expression Profiles of VEGF-A, CD31 and GRP78 in Non-Small Cell Lung Cancer.

Al-Keilani¹,

Alqudah²,

Almomani³

et al. 2020

Preprint

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GRP78 is Overexpressed in Non-small Cell Lung Cancer Tissues and is Associated with High VEGF Expression in Squamous Cell Carcinoma: A Pilot Study

Al-Keilani

Alqudah

Almomani

et al. 2023

CCDT

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Background: Neovascularization is essential for the growth and progression of tumor tissues. GRP78 is frequently overexpressed in various cancers and has been suggested as a proangiogenic factor. Purpose: This study aimed to investigate the expression levels of GRP78 and to test for significant relationships with the angiogenic markers, VEGF, and CD31. Methods: In this study, paraffin-embedded NSCLC tissue samples (71 adenocarcinomas and 23 squamous cell carcinoma) were retrospectively collected from 94 patients with NSCLC. The expressions of VEGF, CD31, and GRP78 were determined by immunohistochemistry. Results: High expression levels of VEGF and GRP78 were observed in 65 and 74 cases, respectively. Thirty-six patients expressed high CD31 levels. Adenocarcinomas expressed higher levels of the three proteins than squamous cell carcinomas (p-value < 0.05). Moreover, a statistically significant association was found between the expression levels of VEGF and CD31 (p-value = 0.001) and VEGF and GRP78 (p-value=0.028). Conclusion: GRP78 overexpression was revealed in most of the investigated samples. The positive association between VEGF and GRP78 may indicate the proangiogenic role of GRP78 in lung cancer. Moreover, the positive association between VEGF and CD31 expression levels suggests that VEGF may cooperate with CD31 to promote angiogenesis in NSCLC.

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Prognostic significance of influence of CD-31 and PDEF expression in patients with non-small-lung cancer

Cited by 2 publications

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Expression Profiles of VEGF-A, CD31 and GRP78 in Non-Small Cell Lung Cancer.

Expression Profiles of VEGF-A, CD31 and GRP78 in Non-Small Cell Lung Cancer.

GRP78 is Overexpressed in Non-small Cell Lung Cancer Tissues and is Associated with High VEGF Expression in Squamous Cell Carcinoma: A Pilot Study

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