Prognostic significance of inflammatory parameters and nutritional index in clinical stage IVB endometrial carcinomas

Kiuchi, Kaori; Hasegawa, Kiyoshi; Ochiai, Shoko; Motegi, E.; Kuno, Tatsuya; Kosaka, Nobuaki; Fukasawa, Ichio

doi:10.1080/01443615.2018.1494703

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…To date, only 1 retrospective study has investigated the prognostic value of PNI in stage IVB endometrial cancer (46). Although low PNI was associated with decreased OS in univariate analysis, no statistical significance was found in the multivariable analysis.…”

Section: Gynecological Cancersmentioning

confidence: 99%

Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review

Li¹,

Nakamura²,

Casadei-Gardini³

et al. 2021

Ann Transl Med

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Objective: To perform a narrative review of the prognostic value of prognostic nutritional index (PNI) in cancers.Background: Prognostic estimation greatly determines the treatment approach in various cancers. The prognostic nutritional index (PNI), calculated using the serum albumin level and total lymphocyte count, is a useful indicator to assess nutritional and immunological conditions. The PNI represents a low-cost, easy-toperform, noninvasive, rapid, and standardized tool for estimating the prognosis of cancer. Many studies have aimed to clarify the prognostic value of PNI for various types of cancer. Methods:We summarize the studies, particularly the systematic reviews and meta-analyses, that have examined the prognostic value of PNI in common cancers. Conclusions:The relevant studies indicate that low PNI is an independent prognostic factor for decreasing overall survival in many types of cancers. Disease-free survival and progression-free survival were also associated with PNI in some types of cancer including lung cancer and renal cell carcinoma. Therefore, we suggest that the measurement of PNI is a useful method to identify cancer patients that have a worse prognosis and that the treatment strategy for these patients be adjusted accordingly. We hypothesize that maintaining good nutritional status during treatment may improve outcomes of various cancers.

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Section: Gynecological Cancersmentioning

confidence: 99%

Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review

Li¹,

Nakamura²,

Casadei-Gardini³

et al. 2021

Ann Transl Med

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“… 13 14 15 However, the role of prognostic PNI remains controversial in patients with EC. A previous clinical report showed that PNI was not an prognostic factor independently, 16 while another study reported that a high preoperative PNI was related with favorable progression-free survival in EC patients. 17 A recent prospective database study also showed that PNI was an independent prognostic factor in EC patients.…”

Section: Introductionmentioning

confidence: 95%

Preoperative Prognostic Nutritional Index Is a Prognostic Indicator of Cancer-Specific Survival in Patients Undergoing Endometrial Cancer Surgery

et al. 2023

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Background The prognostic nutritional index (PNI) reflects systemic inflammation and nutritional status. This study aimed to evaluate the effect of preoperative PNI on postoperative cancer-specific survival in patients with endometrial cancer (EC). Methods Demographic, laboratory, and clinical data were retrospectively collected from 894 patients who underwent surgical resection of EC. Preoperative PNIs were determined from the serum albumin concentration and total lymphocyte count, which were measured within 1 month before surgery. Patients were classified into high PNI (n = 619) and low PNI (n = 275) groups according to the preoperative PNI cut-off value of 50.6. The stabilized inverse probability of treatment weighting (IPTW) method was used to reduce bias: a weighting cohort divided into high PNI (n = 615.4) and low PNI (n = 272.3) groups. The primary outcome measure was postoperative cancer-specific survival. Results The postoperative cancer-specific survival rate was higher in the high PNI group than the low PNI group in the unadjusted cohort (93.1% vs. 81.5%; proportion difference [95% confidence interval; 95% CI], 11.6% [6.6–16.6%]; P < 0.001) and in the IPTW-adjusted cohort (91.4% vs. 86.0%; 5.4% [0.8–10.2%]; P = 0.021). In the multivariate Cox proportional hazard regression model in the IPTW-adjusted cohort, high preoperative PNI (hazard ratio [95% CI], 0.60 [0.38–0.96]; P = 0.032) was an independent determinant of postoperative cancer-specific mortality. The multivariate-adjusted restricted cubic spline curve for the Cox regression model showed a significant negative association between preoperative PNI and postoperative cancer-specific mortality ( P < 0.001). Conclusion High preoperative PNI was associated with improved postoperative cancer-specific survival in patients undergoing surgery for EC.

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“…It is widely accepted that inflammation and nutrition are associated with tumor prognosis. Recently, published researches demonstrated that a range of inflammation-related and/or nutrition-related indicators, such as PNI, PLR, and NLR, is related to tumor prognosis in various cancers, as well as ESCC [ 8 - 12 ]. Compared with other prognostic scores, HALP was considered to be the highest-scoring system for grouping patients with the same prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that nutritional and inflammatory status is associated with cancer prognosis. In recent years, therefore, a variety of inflammation and/or nutrition-related predictors, including platelet to lymphocyte ratio (PLR), prognostic nutritional index (PNI), and neutrophil to lymphocyte ratio (NLR) have been used in various cancers, including ESCC [ 8 - 12 ]. Hemoglobin, albumin, lymphocyte and platelet (HALP) score, consisting of four laboratory markers in both nutritional and inflammatory status, including HALP is recently proposed to predict the prognosis in patients with several types of cancers [ 13 - 16 ].…”

Section: Introductionmentioning

confidence: 99%

The preoperative HALP score (hemoglobin, albumin, lymphocyte and platelet) is a useful predictor in patients with resectable esophageal squamous cell carcinoma

Feng

Wang

Yang

2021

Bosn J of Basic Med Sci

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The hemoglobin, albumin, lymphocyte, and platelet (HALP) score has been confirmed as a prognostic factor in several types of cancers. The current study aimed to assess the prognostic value of preoperative HALP score, an inflammatory and nutritional based score, in predicting cancer-specific survival (CSS) in resectable patients undergoing curative resection for esophageal squamous cell carcinoma (ESCC). The clinical data of 355 consecutive patients with ESCC who underwent curative resection were retrospectively conducted and analyzed. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value for preoperative HALP. The areas under the curve (AUC) for preoperative HALP and other variables were calculated and compared. Cox regression analyses and Kaplan-Meier methods were used to identify the factors associated with CSS. According to the ROC curve, the optimal cut-off value for preoperative HALP was 31.8. The 5-year CSS for preoperative HALP low (≤31.8) and high (>31.8) was 15.1% and 47.5%, respectively (p<0.001). Preoperative HALP had reliable abilities to predict CSS in resectable ESCC patients in any stage or gender, according to the subgroup analysis based on the patients' cancer stage and gender. Multivariate analyses confirmed that preoperative HALP was an independent prognostic score regarding CSS in patients with resectable ESCC (p<0.001). This study confirmed that the preoperative HALP score could be regarded as a potential independent prognostic factor for CSS in patients with resectable ESCC.

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Prognostic significance of inflammatory parameters and nutritional index in clinical stage IVB endometrial carcinomas

Cited by 10 publications

References 17 publications

Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review

Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review

Preoperative Prognostic Nutritional Index Is a Prognostic Indicator of Cancer-Specific Survival in Patients Undergoing Endometrial Cancer Surgery

The preoperative HALP score (hemoglobin, albumin, lymphocyte and platelet) is a useful predictor in patients with resectable esophageal squamous cell carcinoma

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