Prognostic significance of indocyanine green clearance in critically ill surgical patients

Kholoussy, A. Mohsen; Pollack, David A.; Matsumoto, Teruo

doi:10.1097/00003246-198402000-00007

Cited by 50 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While the optimal method to assess the hepatic dysfunction associated with critical illness has not been identified, hepatocellular enzyme and serum bilirubin levels are most commonly used for screening and monitoring. A number of quantitative measures of hepatic function have been developed but these techniques are frequently labor intensive, cumbersome, and have not been widely adopted (23)(24)(25). Serum bilirubin has been incorporated into several severity of illness scoring systems (12)(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Transcutaneous Bilirubinometry in Hospitalized Adults

Rosengart

Bukauskas

Zenati

et al. 2008

Journal of the American College of Surgeons

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of Transcutaneous Bilirubinometry in Hospitalized Adults

Rosengart

Bukauskas

Zenati

et al. 2008

Journal of the American College of Surgeons

View full text Add to dashboard Cite

show abstract

“…8,9 It has been suggested that it is useful as a prognostic indicator in hepatic resection and in predicting the prognosis of acutely ill patients. 10,11 However, its use in clinical practice has been hindered by the fact that most measurement methods are invasive, cumbersome and time-consuming. Our method measures the ICG elimination rate constant (k) and in the present study we have shown this to correlate well with that measured by spectrophotometry, which is the currently accepted method of measuring peripheral ICG-k and clearance.…”

Section: Discussionmentioning

confidence: 99%

Cerebral near infrared spectroscopy for the measurement of indocyanine green elimination in cirrhosis

Therapondos

Plevris

Stanley

et al. 2000

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Background: Indocyanine green (ICG) clearance is a useful indicator of hepatic function but most measurement methods are invasive. Aim: To validate a less invasive technique using cerebral near infrared spectrophotometry (NIRS) to measure ICG elimination, and to compare it with the established methods for the determination of ICG clearance in a group of normal controls and patients with cirrhosis. Method: NIRS was used to measure ICG elimination in 41 cirrhotic patients and nine healthy volunteers. The first 13 of the cirrhotic patients also had their ICG clearance measured by the conventional spectrophotometric technique. Results: NIRS ICG elimination rate (ICG‐k) and spectrophotometry ICG‐k values correlated strongly (r= 0.828, P < 0.001, n=13). There was a significant reduction in the mean NIRS‐k in cirrhotic patients and within Child–Pugh classes A, B, and C (P < 0.001). Conclusion: Measurement of ICG elimination by the NIRS method is at least as reliable as the conventional spectrophotometric technique in normals and in patients with cirrhosis. This technique merits further development for use as a bedside, less invasive liver function test.

show abstract

“…Bisherige Untersuchungen konnten bei kritisch kranken Patienten die prognostische Bedeutung der ICG-PDR, auch innerhalb verschiedener Subkollektive aufzeigen (z. B. ARDS-, Sepsispatienten; [17,18]). Kimura et al [19] konnten nachweisen, dass die Entwicklung der ICG-PDR im manifesten septischen Schock im Vergleich zu Serummarkern deutlich sensitiver zur Beurteilung der Organdysfunktionen ist.…”

Section: Diskussionunclassified

Indozyaningrünplasmaverschwinderate

Seibel

Sakka

2010

Anaesthesist

View full text Add to dashboard Cite

Increased intraabdominal pressure (IAP) and abdominal compartment syndrome (ACS) are diseases which are often underestimated with respect to incidence and prognosis especially in critically ill patients. The clinical gold standard for the determination of IAP is the urinary bladder measurement technique. For assessment of hepatosplanchnic perfusion the indocyanine green plasma disappearance rate (ICG-PDR) has recently become a clinically attractive method. In this investigation a decrease in splanchnic perfusion caused by increased IAP was observed in critically ill patients with abdominal focused sepsis or postoperative systemic inflammatory response syndrome (SIRS). It was found that the reduction of ICG-PDR as a measure of splanchnic blood flow correlated with the increase of IAP, i.e. increased IAP is associated with lower ICG-PDR. Furthermore, the data suggest that a relevant decrease of splanchnic blood flow may appear even during lower IAP than previously assumed.

show abstract

Prognostic significance of indocyanine green clearance in critically ill surgical patients

Cited by 50 publications

References 0 publications

Assessment of Transcutaneous Bilirubinometry in Hospitalized Adults

Assessment of Transcutaneous Bilirubinometry in Hospitalized Adults

Cerebral near infrared spectroscopy for the measurement of indocyanine green elimination in cirrhosis

Indozyaningrünplasmaverschwinderate

Contact Info

Product

Resources

About