Prognostic Significance of Immunohistochemically Detected Blood and Lymphatic Vessel Invasion in Colorectal Carcinoma: Its Impact on Prognosis

Liang, Pan; Nakada, Ichiro; Hong, Jian-Wei; Motohashi, Gyo; Takemura, Akihiro; Nakachi, Takeshi; Kasuga, Teruhiko; Tabuchi, Takafumi

doi:10.1245/s10434-006-9189-3

Cited by 72 publications

(66 citation statements)

References 25 publications

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“…The prognostic value of LVI has been shown in patients with solid tumors like breast cancer [28], colorectal carcinoma [29] and gastric carcinoma [30,31]. In the current study, on univariate survival analysis, patients with LVI had a significantly shorter disease-free survival, cancer-specific survival and overall survival.…”

Section: Discussionmentioning

confidence: 49%

Lymphatic vessel invasion detected by the endothelial lymphatic marker D2-40 (podoplanin) is predictive of regional lymph node status and an independent prognostic factor in patients with resected esophageal cancer

Kozłowski¹,

Naumnik²,

Nikliński³

et al. 2011

Folia Histochem Cytobiol.

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Abstract:The discovery of markers to lymphatic endothelial cells and the development of novel antibodies to these markers have brought increasing attention to the lymphatics and progress in the understanding of lymphangiogenesis and cancer metastasis. In this study, we investigate the presence of lymphatic vessel invasion (LVI) detected by D2-40 immunohistochemical staining in resected esophageal cancer and correlated with clinicopathologic data and patient survival. Sixty nine patients, who had a primary resection of esophageal cancer, were analyzed by univariate and multivariate logistic regression, and univariate and multivariate survival analysis. The total rate of LVI was 72% (50/69). Positive LVI was significantly correlated with lymph node metastasis (p < 0.001), tumor size (p < 0.001), histological grading (p = 0.017), tumor depth (p = 0.001), and stage (p < 0.001). Multivariate logistic analysis identified LVI (p = 0.036) as a predictor of regional lymph node metastasis. On univariate survival analysis, patients with LVI had a significantly shorter disease-free survival, cancer-specific survival and overall survival. Multivariate analysis proved that LVI diagnosed by D2-40 is an independent prognostic factor of both disease-free survival (p = 0.04) and overall survival (p = 0.032) in resected esophageal cancer. These results show that LVI assessment identifies patients at high risk for regional lymph node metastasis and that LVI is an independent prognostic factor in patients with esophageal cancer. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 90-97) Key words: esophageal cancer, lymphatic vessel invasion, podoplanin, D2-40, lymph node metastasis, prognosis ageal cancer. More than 65% of patients with localized esophageal cancers and negative resection margin have a positive lymph node at the time of surgery [1]. However, despite complete tumor resection and extensive lymphadenectomy, systemic and local recurrence is common [2] and the five-year survival rate is 15-39% [3].The discovery over the last decade of markers of lymphatic endothelial cells like podoplanin (D2-40) [4], LYVE-1 [5] and Prox 1 [6], and the development of novel antibodies to these markers, have generated

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Section: Discussionmentioning

confidence: 49%

Lymphatic vessel invasion detected by the endothelial lymphatic marker D2-40 (podoplanin) is predictive of regional lymph node status and an independent prognostic factor in patients with resected esophageal cancer

Kozłowski¹,

Naumnik²,

Nikliński³

et al. 2011

Folia Histochem Cytobiol.

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“…Reported inherent false-negative rate in histological diagnosis of venous invasion ranges from 10.5% to 29.6%. 11 Some investigators have added immunohistochemical staining to lower this false-negative rate 13 ; however, it has been shown that interobserver variability is not improved by the use of immunohistochemical stains against CD31 and D2-40. 12 Furthermore, the College of American Pathologists' consensus statement does not recommend the use of any special stains or immunohistochemical stains to diagnose vessel invasion.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Lymphovascular Invasion in Sporadic Colorectal Cancer

Lim

Yu²,

Jang³

et al. 2010

Diseases of the Colon &Amp; Rectum

157

100

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“…These markers enable the identification of lymphatic vessels immunohistochemically. Lymphatic vessel density (LVD) has been assessed using antibodies to lymphatics in a variety of malignancies, including cancers of pancreate endocrine, breast, head and neck, lung and colorectal [7][8][9][10][11][12][13]. The presence of intratumoral lymphatic vessels and occurrence of intratumoral lymphangiogenesis have been demonstrated by the identification of intratumoral lymphatic vessels and demonstration of the presence of proliferating intratumoral lymphatic vessels in a number of cancers [14].…”

Section: Introductionmentioning

confidence: 99%

“…Lymphatic vessel invasion (LVI) is a critical step in primary tumor cells' dissemination through lymphatics [11]. LVI has been shown to correlate with lymph node metastasis and clinicopathological characteristics [10,21].…”

Section: Introductionmentioning

confidence: 99%

Intratumoral as well as peritumoral lymphatic vessel invasion correlates with lymph node metastasis and unfavourable outcome in colorectal cancer

Mei

Lin

et al. 2010

Clin Exp Metastasis

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The aim of this study was to assess the intratumoral and peritumoral distribution of lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) in colorectal cancer and their relationships with patients' clinicopathological characteristics and survival. Paraffin sections of 81 primary colorectal cancers were examined by immunohistochemical staining using monoclonal antibody D2-40. Peritumoral LVD was significantly higher than intratumoral LVD (P = 0.000). Both intratumoral LVD and peritumoral LVD were correlated with the presence of LVI (P = 0.006 and P = 0.003, respectively). LVI, intratumoral LVI and peritumoral LVI were identified, respectively in 38, 28 and 32% of the samples investigated. Both intratumoral LVI and peritumoral LVI were correlated with lymph node metastasis (P = 0.030 and P = 0.014, respectively). Lymph node metastasis, the presence of intratumoral LVI and peritumoral LVI were adversely associated with the 5-year overall survival in a univariate analysis (P = 0.001, P = 0.011 and P = 0.017, respectively). Multivariate analysis using Cox proportional hazard model showed that neither intratumoral LVI nor peritumoral LVI was an independent prognostic factor of overall survival. The results of this study demonstrated that intratumoral as well as peritumoral LVI was associated with lymph node metastasis and adverse outcome in colorectal cancer.

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Prognostic Significance of Immunohistochemically Detected Blood and Lymphatic Vessel Invasion in Colorectal Carcinoma: Its Impact on Prognosis

Cited by 72 publications

References 25 publications

Lymphatic vessel invasion detected by the endothelial lymphatic marker D2-40 (podoplanin) is predictive of regional lymph node status and an independent prognostic factor in patients with resected esophageal cancer

Lymphatic vessel invasion detected by the endothelial lymphatic marker D2-40 (podoplanin) is predictive of regional lymph node status and an independent prognostic factor in patients with resected esophageal cancer

Prognostic Significance of Lymphovascular Invasion in Sporadic Colorectal Cancer

Intratumoral as well as peritumoral lymphatic vessel invasion correlates with lymph node metastasis and unfavourable outcome in colorectal cancer

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