Prognostic Significance of Hysteroscopic Imaging in Endometrioid Endometrial Adenocarcinoma

Garuti, Giancarlo; Giorgi, Olga De; Sambruni, Ivan; Cellani, Fulvia; Luerti, Massimo

doi:10.1006/gyno.2001.6173

Cited by 24 publications

(18 citation statements)

References 23 publications

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“…He concluded that these characteristics depend upon the superficial components of cancer tissue, so hysteroscopic findings were correlated with the histopathology of superficial areas of lesions from hysterectomy specimens. However, Garuti et al [6] reported that the morphology of adenocarcinomas was unrelated to both their stage and their grade.…”

Section: Discussionmentioning

confidence: 99%

“…And although not statistically significant, the value of G3 was greater than G1 (p = 0.10) and than (G1 and G2) group (p = 0.06). The biochemical pathways leading to the heterogeneous moulding of epithelial endometrial neoplasias are unknown but probably related to multiple different and specific roles played by growth factors, growth factor receptors, angiogenic stimuli, and paracrine interactions between stromal and epithelial tumor cells [6]. However, considering the tumor growth as complex systems as a whole, the surface morphology of the cancer is the end result of physical and biological processes that modify shape through local action.…”

Section: Discussionmentioning

confidence: 99%

“…More than 20 years ago, Sugimoto [4,5] first categorized the morphologic features of endometrial adenocarcinoma by hysteroscopy, but few data have been published about the relationship between morphology of tumor growth and the staging of disease according to the 1988 FIGO recommendations [6]. That is, in contrast with the volume of knowledge concerning extrauterine spread of endometrial carcinoma, little is known of the patterns of intrauterine growth.…”

Section: Introductionmentioning

confidence: 98%

“…That is, in contrast with the volume of knowledge concerning extrauterine spread of endometrial carcinoma, little is known of the patterns of intrauterine growth. Garuti et al [6] reported that neither nodular, polypoid, nor papillomatous modalities of cancer growth were related to surgical stage or pathologic grade of the disease, and in their experience these various patterns of growth appear to have no clinical significance. However, the morphologic categorization used in their and previous studies is subjective and may be too simple to discriminate subtle morphologic differences in growth patterns among biologically diverse groups.…”

Section: Introductionmentioning

confidence: 99%

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Fractal Analysis of Surface Growth Patterns in Endometrioid Endometrial Adenocarcinoma

Kikuchi

Kozuma²,

Yasugi³

et al. 2004

Gynecol Obstet Invest

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Objective: A fractal is a shape made of parts similar to the whole in some way. The objective of this study was to determine whether surface growth patterns in endometrioid endometrial adenocarcinoma are fractal, and the mean fractal dimension differs according to histologic grades and depth of myometrial invasion. Methods: After the images of photographs of 120 resected uteri with endometrial cancers were digitized, the fractal dimensions of surface of tumors were measured using a fractal analysis software. Results: The mean fractal dimensions of surface growth patterns in G1, G2, and G3 adenocarcinoma were 2.318, 2.303, and 2.383, respectively. These values were significantly greater than the topological dimension of a surface (= 2). The value was significantly higher in G3 than in G2 (p = 0.03). And although not statistically significant, the value of G3 was greater than G1 (p = 0.10) and than (G1 and G2) group (p = 0.06). No significant difference nor tendency was found in the fractal dimension of the surface of the tumor according to depth of invasion. Conclusion: This study shows that the surface of endometrioid endometrial adenocarcinoma has a fractal structure, and the mean fractal dimension may differ according to histologic grades. Our report proposes a new way of looking at endometrial cancer pathology. We believe that fractal geometry gives insights into tumor morphology and becomes a useful tool for analyzing complex and irregular tumor growth patterns mathematically.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fractal Analysis of Surface Growth Patterns in Endometrioid Endometrial Adenocarcinoma

Kikuchi

Kozuma²,

Yasugi³

et al. 2004

Gynecol Obstet Invest

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“…The procedure allows a surgeon to directly assess the extent of endometrial involvement by cancer [62][63][64] , leading to a better coverage of surgical treatment. The extent of EMC involvement can also serve as a prognostic indicator.…”

Section: Myometrial Invasionmentioning

confidence: 99%

Fertility-Sparing in Endometrial Cancer

Tangjitgamol

Manusirivithaya²,

Hanprasertpong³

2009

Gynecol Obstet Invest

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Because endometrial cancer (EMC) patients frequently present at an early stage of disease, most have favorable outcomes, thus their quality of life after treatment is as important a consideration as a cure of cancer. This issue is especially important when EMC is encountered in younger or reproductive ages when the afflicted woman has not achieved her fertility function. It is a complicated situation when a physician encounters a request or question from a woman with EMC or her family concerning whether she could conceive a child prior to a definite cancer treatment. Despite being an interesting issue, there are only a few studies with definite treatment guidelines or any evidence-based recommendations concerning conservative treatment for EMC. Thus, we undertook this study to explore various considerations regarding the criteria and caveats for the management of EMC women who desire to preserve their fertility function. An algorithm guideline for conservative fertility treatment for EMC is also presented.

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Interventional Diagnostics Before Hysterectomy

Haimovich¹

2017

Hysterectomy

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Prognostic Significance of Hysteroscopic Imaging in Endometrioid Endometrial Adenocarcinoma

Cited by 24 publications

References 23 publications

Fractal Analysis of Surface Growth Patterns in Endometrioid Endometrial Adenocarcinoma

Fractal Analysis of Surface Growth Patterns in Endometrioid Endometrial Adenocarcinoma

Fertility-Sparing in Endometrial Cancer

Interventional Diagnostics Before Hysterectomy

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