Prognostic significance of HALP (hemoglobin, albumin, lymphocyte and platelet) in patients with bladder cancer after radical cystectomy

Ding, Peng; Zhang, Cui-jian; Gong, Yanqing; Hao, Han; Guan, Bao; Li, Xuesong; Zhou, Liqun

doi:10.1038/s41598-018-19146-y

Cited by 92 publications

(95 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The nomogram indicated that age ≥ 36.5, female, coma and straight sinus thrombosis location were the poor prognostic factors, but higher HALP was still a potential good prognostic factor. The results of the nomogram were similar to those of aforementioned multivariate analyses in tumor [10][11][12] .…”

Section: Resultssupporting

confidence: 76%

“…It was the integration of these four indexes and relatively more stable than single blood parameters. HALP was closely associated with clinical features and was an independent prognostic factor in several types of malignant tumors, including genitourinary cancer, bladder cancer and renal cell carcinoma [10][11][12] . However, there were no reports concerned with roles of HALP in CVST patients, especially in acute and subacute CVST patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Novel Biomarkers-Based HALP (Hemoglobin, Albumin, Lymphocyte and Platelet)-Prognostic Model for Acute and Subacute Patients with Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study

Shen

Gao

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background and purpose: To evaluate the prognosis values of HALP in acute or subacute cerebral venous sinus thrombosis (CVST), to explore the new prognostic model for CVST.Methods: Consecutive patients who were diagnosed as having acute and subacute CVST were retrospectively investigated. We determined the patients' functional outcomes by modified Rankin Scale (mRS). Multivariate logistic regression analysis was used to assess the relationship between factors and poor functional outcomes. The area under the ROC curve (AUC) was estimated to evaluate the ability of markers and models in predicting clinical prognosis. The prognostic model was presented as nomogram. In addition, the decision curve analysis (DCA) was used to analyze the benefit of this model. Furthermore, survival curves were described by the Kaplan‑Meier analysis. Results: A total of 270 patients were included of which 31 had poor outcome. Multivariable logistic regression analysis demonstrated HALP (OR=0.978, 95%CI: 0.958-0.999, P=0.039) was a protective predictor of outcome. The AUC of HALP was 0.749 (95% CI: 0.633-0.865, P=0.044). DCA demonstrated that this model significantly improved risk prediction at threshold probabilities of CVST at 0 to 85%. Patients with higher HALP (P=0.006) presented higher overall survival rates. Conclusions: HALP may be a potential protective marker in acute and subacute CVST patients. The new prognostic model with HALP had potentially better value for Chinese CVST patients.

show abstract

Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

The Novel Biomarkers-Based HALP (Hemoglobin, Albumin, Lymphocyte and Platelet)-Prognostic Model for Acute and Subacute Patients with Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study

Shen

Gao

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…So far, no study has investigated the association between HALP score and AIS. Recent studies have shown that the HALP score can re ect the in ammation-nutritional status of patients [14,29], and has been proved to be an important prognostic indicator for patients with pancreatic cancer [13], esophageal squamous cell carcinoma [15], and bladder cancer [16]. Anemia and thrombosis could exacerbate in ammation while lymphocytes reduce in ammation [30].…”

Section: Discussionmentioning

confidence: 99%

“…The hemoglobin, albumin, lymphocyte and platelet (HALP) score is considered to be an easily calculated marker of systemic in ammation and nutritional status [13,14] and has been con rmed as a signi cant prognostic factor in patients with pancreatic cancer, esophageal squamous cell carcinoma, and bladder cancer [15,16]. However, it is unknown whether HALP score is associated with the adverse clinical events of AIS.…”

Section: Introductionmentioning

confidence: 99%

Hemoglobin, Albumin, Lymphocyte, and Platelet Score is Associated With Adverse Clinical Outcomes of Acute Ischemic Stroke: A Prospective Cohort Study

Tian

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The combined index of hemoglobin, albumin, lymphocyte and platelet (HALP) is considered as a novel score to reflect systemic inflammation and nutritional status. This study aimed to investigate the association between HALP score and adverse clinical events in patients with acute ischemic stroke (AIS). Methods This study prospectively included patients with AIS within 24 hours of admission to the First Affiliated Hospital of Zhengzhou University. The primary outcomes were all-cause death within 90 days and 1 year. The secondary outcomes included stroke recurrence and combined vascular events. The association between HALP score and adverse clinical outcomes was analyzed using Cox proportional hazards. Results A total of 1337 patients were included. Patients in the highest tertile of HALP score had a lower risk of death within 90 days and 1 year (Hazard ratio: 0.20 and 0.30; 95% confidence intervals: 0.06–0.66 and 0.13–0.69, P for trend < 0.01 for all) compared with the lowest tertile after adjusting relevant confounding factors. Similar results were found for secondary outcomes. Subgroup analyses further confirmed these association. Adding HALP score to the conventional risk factors improved prediction of death in patients with AIS within 90 days and 1 year (net reclassification index, 38.63% and 38.68%; integrated discrimination improvement, 2.43% and 2.57%; P < 0.02 for all). Conclusions High HALP score levels were associated with decreased risk of adverse clinical outcomes within 90 days and 1 year after stroke onset, suggesting that HALP score may serve as a powerful indicator for AIS.

show abstract

“…This novel score system has proven to be a good prognostic indicator in gastric, colorectal, renal, bladder, and prostate cancers. [7][8][9][10][11] However, there have been no studies which have been performed an assessment on the HALP score as a diagnostic marker of PCa. In this study we aimed to investigate if there was any statistically significant difference of the HALP score between patients with PCa or BPH.…”

Section: Introductionmentioning

confidence: 99%

HALP Score and Albumin Levels in Men with Prostate Cancer and Benign Prostate Hyperplasia

Kaya

Çalışkan²,

Sungur

et al. 2020

Preprint

View full text Add to dashboard Cite

Aims: To evaluate the diagnostic significance of the novel index combining preoperative hemoglobin, albumin levels, lymphocyte and platelet counts (HALP) in prostate cancer (PCa) patients. Methods: Between January 1, 2015 to December 31, 2018 at the Hitit University Erol Olçok Education and Research Hospital 225 patients who had undergone transrectal ultrasound guided prostate biopsy or prostate surgery were analyzed retrospectively. A total of patients; 155 had benign prostate hyperplasia (group 1) and 70 had PCa (group 2). The preoperative serum levels of hemoglobin, albumin, lymphocyte counts, and platelet counts were recorded. The HALP scores and the sub parameters of this index for each of the two groups were compared. Results: The total Prostate Specific Antigen (PSA), albumin and lymphocyte differences between the groups were statistically significant (p=0.0002, p=0.0001, p= 0.005). The median value of HALP scores in Group 1 and 2 were 49.43 and 51.2 respectively, and this was not statistically significant between groups (p=0.737). The HALP score had the least Area Under Curve (AUC) value compared to the others (0.514). the AUC of Albumin was larger than PSA for diagnostic efficacy in PCa patients (0.696-0.656). However, albumin levels were statistically significant compared to platelet count and the HALP score (p=0.0033, p=0.0068), except PSA and lymphocyte (p=0.4580, p=0.1717). Conclusion:Further prospective clinical studies that include more patients from multiple centers are needed to show the diagnostic role of the HALP score and its compounds on the patients with PCa.

show abstract

Prognostic significance of HALP (hemoglobin, albumin, lymphocyte and platelet) in patients with bladder cancer after radical cystectomy

Cited by 92 publications

References 21 publications

The Novel Biomarkers-Based HALP (Hemoglobin, Albumin, Lymphocyte and Platelet)-Prognostic Model for Acute and Subacute Patients with Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study

The Novel Biomarkers-Based HALP (Hemoglobin, Albumin, Lymphocyte and Platelet)-Prognostic Model for Acute and Subacute Patients with Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study

Hemoglobin, Albumin, Lymphocyte, and Platelet Score is Associated With Adverse Clinical Outcomes of Acute Ischemic Stroke: A Prospective Cohort Study

HALP Score and Albumin Levels in Men with Prostate Cancer and Benign Prostate Hyperplasia

Contact Info

Product

Resources

About