Prognostic Significance of Ground-Glass Opacity Components in 5-Year Survivors With Resected Lung Adenocarcinoma

Shigefuku, Shunsuke; Shimada, Yoshihisa; Hagiwara, Masaru; Kakihana, Masatoshi; Kajiwara, Naohiro; Ohira, Tetsuya; Ikeda, Norihiko

doi:10.1245/s10434-020-09125-x

Cited by 21 publications

(18 citation statements)

References 34 publications

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“…Seventy full tests were reviewed for eligibility, and 58 publications were excluded because of insufficient data ( n = 55) and overlapping data ( n = 3). Finally, a total of 12 studies were included in this meta-analysis for further analysis[ 18 - 29 ] (Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies explored the association between the presence of GGO on CT and OS of stage I lung adenocarcinoma patients[ 18 , 20 - 23 , 27 - 29 ]. The pooled results indicated that GGO was significantly related with better OS (HR = 0.44, 95%CI: 0.34-0.59, P < 0.001; I 2 = 24.3%, P = 0.236) (Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Although we conducted subgroup analysis based on the GGO ratio in pulmonary nodules and manifested that patients with a higher ratio of GGO on CT would experience better prognosis than patients with a lower ratio of GGO did, we still deemed that it was necessary to explore the association between the proportion of GGO and survival risk. Half of the included studies simply divided patients into the GGO group (presence of GGO) and non-GGO group (absence of GGO) and only identified the prognostic value of presence of GGO on CT in stage I lung adenocarcinoma patients[ 22 , 24 , 25 , 27 - 29 ]. The other studies divided patients into the higher GGO ratio group and lower GGO ratio group, and most of them defined the 50% as the threshold ratio[ 18 , 21 , 23 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Besides, the study by Shigefuku et al [ 29 ] reported the association between the presence of GGO on CT and cancer-specific survival (CSS) of stage I lung adenocarcinoma patients and manifested that GGO was also a significant predictive indicator for improved CSS (HR = 0.509, 95%CI: 0.260-0.997, P = 0.049)[ 29 ]. Actually, we deemed that CSS was more valuable than OS in pathologic TNM stage I pulmonary adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis

Pan¹,

Liao²,

Yao³

et al. 2021

WJCC

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BACKGROUND The clinical role of ground glass opacity (GGO) on computed tomography (CT) in stage I pulmonary adenocarcinoma patients currently remains unclear. AIM To explore the prognostic value of GGO on CT in lung adenocarcinoma patients who were pathologically diagnosed with tumor-node-metastasis stage I. METHODS A comprehensive and systematic search was conducted through the PubMed, EMBASE and Web of Science databases up to April 3, 2021. The hazard ratio (HR) and corresponding 95% confidence interval (CI) were combined to assess the association between the presence of GGO and prognosis, representing overall survival and disease-free survival. Subgroup analysis based on the ratio of GGO was also conducted. STATA 12.0 software was used for statistical analysis. RESULTS A total of 12 studies involving 4467 patients were included. The pooled results indicated that the GGO predicted favorable overall survival (HR = 0.44, 95%CI: 0.34-0.59, P < 0.001) and disease-free survival (HR = 0.35, 95%CI: 0.18-0.70, P = 0.003). Subgroup analysis based on the ratio of GGO further demonstrated that the proportion of GGO was a good prognostic indicator in pathological stage I pulmonary adenocarcinoma patients, and patients with a higher ratio of GGO showed better prognosis than patients with a lower GGO ratio did. CONCLUSION This meta-analysis manifested that the presence of GGO on CT predicted favorable prognosis in tumor-node-metastasis stage I lung adenocarcinoma. Patients with a higher GGO ratio were more likely to have a better prognosis than patients with a lower GGO ratio.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis

Pan¹,

Liao²,

Yao³

et al. 2021

WJCC

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“…However, more than 97% of GGNs identified by LDCT are benign, with only 0.7%-2.3% of GGNs diagnosed as lung cancer (8)(9)(10). GGN lung adenocarcinoma is characterized by indolent development with few distant metastases and has a favorable prognosis, with a 5-year survival rate of 100% after surgery (11)(12)(13)(14)(15)(16). Thus, GGN lung adenocarcinoma is deemed a special subtype of lung cancer that differs from traditional early-stage lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Cost and effectiveness of microwave ablation versus video-assisted thoracoscopic surgical resection for ground-glass nodule lung adenocarcinoma

et al. 2022

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PurposeTo retrospectively evaluate the cost and effectiveness in consecutive patients with ground-glass nodules (GGNs) treated with video-assisted thoracoscopic surgery (VATS; i.e., wedge resection or segmentectomy) or microwave ablation (MWA).Materials and methodsFrom May 2017 to April 2019, 204 patients who met our study inclusion criteria were treated with VATS (n = 103) and MWA (n = 101). We calculated the rate of 3-year overall survival (OS), local progression-free survival (LPFS), and cancer−specific survival (CSS), as well as the cost during hospitalization and the length of hospital stay.ResultsThe rates of 3-year OS, LPFS, and CSS were 100%, 98.9%, and 100%, respectively, in the VATS group and 100%, 100% (p = 0.423), and 100%, respectively, in the MWA group. The median cost of VATS vs. MWA was RMB 54,314.36 vs. RMB 21,464.98 (p < 0.001). The length of hospital stay in the VATS vs. MWA group was 10.0 vs. 6.0 d (p < 0.001).ConclusionsMWA had similar rates of 3-year OS, LPFS, and CSS for patients with GGNs and a dramatically lower cost and shorter hospital stay compared with VATS. Based on efficacy and cost, MWA provides an alternative treatment option for patients with GGNs.

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Histone lysine methyltransferase SETDB2 suppresses NRF2 to restrict tumor progression and modulates chemotherapy sensitivity in lung adenocarcinoma

Yuan

et al. 2022

Cancer Medicine

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Objective Aberrant epigenetic remodeling represents a molecular hallmark in lung adenocarcinoma (LUAD). We aim to investigate the biological roles of SETDB2 and its underlying associations with oxidative stress, providing therapeutic targets for individualized treatment of LUAD. Methods Differential analysis was conducted via Limma package, and Kaplan–Meier analysis was performed with survival package. CCK‐8, cell proliferation assay, transwell assay, and in vivo assays were conducted to assess the function of SETDB2. Western blot assay, RT‐qPCR, and immunohistochemistry (IHC) were conducted to assess the expression levels of SETDB2/NRF2. Chromatin immunoprecipitation (ChIP) assay and ChIP‐qPCR were conducted to assess the epigenetic roles of SETDB2. Results We found that SETDB2 expression is decreased in tumor samples versus normal tissues in TCGA‐LUAD cohort, LUAD‐EAS cohort, GSE72094 dataset, and independent Soochow‐LUAD dataset. Patients with low SETDB2 levels had a worse prognosis relative to those with high SETDB2. SETDB2 inhibition could significantly promote cell growth, migration ability, and stemness maintenance. Gene set enrichment analysis (GSEA) suggested that SETDB2 correlated with oxidative stress crosstalk and regulated NRF2 mRNA levels. ChIP assay suggested that SETDB2 mainly recruited the H3K9me3 enrichment at the NRF2 promoter region to suppress the mRNA levels of NRF2. Downregulated SETDB2 could activate NRF2 transcription and expression, thereby promoting its downstream targets, like NQO1, FTH1, and ME1. Functional experiments demonstrated that low SETDB2 allowed NRF2 to drive malignant processes of LUAD. SETDB2 overexpression attenuated the ability of NRF2 signaling to neutralize cellular reactive oxygen species (ROS) levels, leading to enhanced cell apoptosis. Overexpressed SETDB2 could inhibit tumor progression in vivo and further render LUAD cells sensitive to chemotherapy. Conclusions In conclusion, these findings uncovered the suppressive role of SETDB2 in LUAD. SETDB2 negatively regulates NRF2 signaling to modulate tumor progression, which creates a therapeutic vulnerability in LUAD.

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Prognostic Significance of Ground-Glass Opacity Components in 5-Year Survivors With Resected Lung Adenocarcinoma

Cited by 21 publications

References 34 publications

Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis

Prognostic value of ground glass opacity on computed tomography in pathological stage I pulmonary adenocarcinoma: A meta-analysis

Cost and effectiveness of microwave ablation versus video-assisted thoracoscopic surgical resection for ground-glass nodule lung adenocarcinoma

Histone lysine methyltransferase SETDB2 suppresses NRF2 to restrict tumor progression and modulates chemotherapy sensitivity in lung adenocarcinoma

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