Prognostic Significance of Gallium Lung Scans in Sarcoidosis

Niden, Albert H.; Mishkin, Fred S.; Salem, Frank A.; Thomas, Alvin V.; Kamdar, Vijay

doi:10.1111/j.1749-6632.1986.tb18520.x

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…Several studies have focused on the role of the 67 Ga scan in the prognosis of sarcoidosis. Niden et al [10] reported that the lesser the degree of pulmonary 67 Ga uptake the better the prognosis of the patient. Likewise, restoration and maintenance of normal 67 Ga scan results during therapy was a good prognostic sign, since such patients did not show loss of pulmonary function.…”

Section: Gallium-67 Scintigraphymentioning

confidence: 99%

“…For this reason, the true frequency of bone involvement by sarcoidosis is probably underestimated due to the asymptomatic nature of most of these lesions and the absence of justification for bone scanning in all patients with sarcoidosis. A bone scan, unlike the 67 Ga scan, is not able to detect intrathoracic and other extrathoracic sites of involvement by sarcoidosis [10,53]. Recently, Milman et al [49] assessed the value of routine bone scintigraphy in the detection of osseous and joint lesions in a series of 63 Caucasian patients with pulmonary sarcoidosis, none of whom exhibited symptoms suggesting bone involvement.…”

Section: Technetium-99m Bone Scintigraphymentioning

confidence: 99%

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Clinical usefulness of nuclear imaging techniques in sarcoidosis

Mañá¹,

Kroonenburgh²

2005

Sarcoidosis

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Nuclear imaging techniques play a role in the assessment and management of patients with sarcoidosis. A variety of radiopharmaceuticals have been introduced for this purpose since the late 1970s. The present chapter focuses on these radiopharmaceuticals, scintigraphic imaging techniques, and their role and clinical value in sarcoidosis. Correlation with other imaging modalities, biochemical parameters and pulmonary function tests are discussed. Integration of the currently available data and the present authors' own experience have permitted the development of an algorithm, in which the current authors suggest a clinical guideline focused on optimal use of nuclear imaging techniques in the initial study of patients with sarcoidosis.

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Section: Gallium-67 Scintigraphymentioning

confidence: 99%

Section: Technetium-99m Bone Scintigraphymentioning

confidence: 99%

Clinical usefulness of nuclear imaging techniques in sarcoidosis

Mañá¹,

Kroonenburgh²

2005

Sarcoidosis

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“…67Ga scans have a high sensitivity (>90%) but a poor specificity (30-60%) for detecting clinically active disease [7,8]. Most studies indicate that 67Ga scanning is not helpful for treatment decisions [9][10][11]. Considering also the diasadvantages of costs, radiation exposure and problems with standardization, 67Ga scan cannot be recommended for routine use in staging of sarcoidosis.…”

Section: Meeting Reportmentioning

confidence: 99%

Consensus conference: activity of sarcoidosis. Third WASOG meeting, Los Angeles, USA, September 8-11, 1993

1994

Eur Respir J

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“…Various authors have proposed 6VGa-imaging as an aid in the diagnosis, evaluation of disease activity, and the assessment of therapy (Heshiki 1974;Niden 1976;Siemsen Fig. 4a Nosal 1979;Line 1981, Schoenberger 1982Beaumont 1982;Gupta 1982;K6hn , 1983aKeogh 1983;Baughman 1984;Klech 1984Klech , 1985bHollinger 1985;Mishkin 1985;Niden 1986;Israel 1986;Rizzato 1986).…”

Section: Sarcoidosismentioning

confidence: 99%

Thoracic imaging with 67gallium

et al. 1987

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In the past, gallium-67 imaging has undergone several ups and downs related to its clinical importance. After a period of initial enthusiasm, its role and indications are now established. At present, there are two fields of clinical interest for 67Ga-imaging: (1)mediastinal staging in bronchogenic carcinoma and the staging of malignant lymphoma; (2) assessment of activity in interstitial lung diseases, especially sarcoidosis and inflammatory lung disorders. The advantage of 67Ga-imaging is that it is highly sensitive for the detection of neoplastic and inflammatory processes, independent of anatomical barriers. Particularly with the challenge of AIDS, 67Ga-imaging will gain increasing importance in the future. The low specificity of gallium for detecting underlying disorders precludes its use as a primary diagnostic tool. Therefore, and because of the cost and radiation load, the indications for application will have to be selected very carefully.

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Prognostic Significance of Gallium Lung Scans in Sarcoidosis

Cited by 11 publications

References 38 publications

Clinical usefulness of nuclear imaging techniques in sarcoidosis

Clinical usefulness of nuclear imaging techniques in sarcoidosis

Consensus conference: activity of sarcoidosis. Third WASOG meeting, Los Angeles, USA, September 8-11, 1993

Thoracic imaging with 67gallium

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