Prognostic Significance of Galectin-3 Measurement in Patients With Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease

Драпкина, О. М.; Deeva, T. A.

doi:10.15829/1728-8800-2015-5-40-47

“…Помимо классических маркеров воспаления, таких как СРБ и интерлейкин (ИЛ)-6, в качестве ассоциированных с ожирением провоспалительных цитокинов были описаны ИЛ-12, ИЛ-23, фактор некроза опухолей альфа (ФНО-α), галектин-3, трансформирующий фактор роста и др. [30,31]. В настоящем обзоре представлены результаты последних исследований, посвященных анализу ряда циркулирующих биомаркеров воспалительных реакций, наиболее интересных с клинической и лабораторной точек зрения.…”

Section: биомаркеры воспаленияunclassified

“…В человеческом организме галектин-3 участвует в различных биологических процессах, включая фиброгенез, пролиферацию фибробластов, регуляцию ремоделирования кардиоваскулярной системы. Галектин считается перспективным биомаркером, гиперсекреция которого ассоциирована с сердечной недостаточностью, а его значение в качестве биомаркера ожирения в настоящее время активно изучается [30]. В исследовании, проведенном Gopal DM, et al, анализировалась связь циркулирующих концентраций галектина-3 с развитием осложнений у асимптоматических пациентов молодого возраста с ожирением.…”

Section: биомаркеры воспаленияunclassified

Circulating biological markers of obesity: towards a systems approach

Timofeev¹,

Джиоева²,

Drapkina³

2023

Cardiovasc Ther Prev

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The pathological processes associated with obesity are based on impaired energy homeostasis, as well as excessive endocrine and paracrine activity of adipose tissue, leading to inflammation and hormonal imbalance, which is accompanied by the secretion of a wide range of compounds affecting key body processes. One of the indirect methods for assessing the adipose tissue abnormalities is the measurement of the concentration of cytokines, growth factors, as well as a class of specific compounds — adipokines specific to adipose tissue. The study of circulating biomarkers makes it possible to assess their association with the risk of complications, metabolic obesity, and other clinical and functional features. Such markers include adipokines (leptin, adiponectin, apelin, resistin, omentin, visfatin, chemerin, lipocalin, etc.), inflammation biomarkers, heat shock proteins, which are discussed in detail in this review in the context of their use in obesity and concomitant diseases.

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“…Исследование уровня галектина-3 у больных с ХСН может иметь некоторые преимущества перед определением N-терминального промозгового натрийуретического пептида (NT-proBNP), показатели которого могут меняться под влиянием возраста, наличия хронической болезни почек, фибрилляции предсердий и ожирения, а также скорости развития симптомов недостаточности кровообращения [8][9][10][11].…”

Section: взаимосвязи активности нейрогормональных систем и параметров...unclassified

Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

Подзолков

¹

,

Dragomiretskaya

²

,

Kazadaeva

³

et al. 2022

Russ J Cardiol

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The introduction of novel biomarkers necessitates their detailed study in patients with different heart failure (HF) phenotypes as part of a personalized approach to assessing the disease severity and predicting outcomes.Aim. To assessthe activity of following neurohormonal systems: N-terminal probrain natriuretic peptide (NT-proBNP) and galectin-3 in HF with preserved, mildly reduced and reduced ejection fraction (EF).Material and methods. In 69 patients with NYHA class II-IV HF, along with a general clinical examination, the level of NT-proBNP and serum galectin-3 was determined by enzyme immunoassay.Results. Patients included in the study were divided into 3 groups: preserved EF (HFpEF) — 23 patients, mildly reduced EF (HFmrEF) — 26 patients, and reduced EF (HFrEF) — 20 patients. In patients with HF, the level of galectin-3 did not directly depend on EF, but was associated with NT-proBNP level as follows: there was a tendency to increase the concentration of galectin-3 in the tertile groups of NT-proBNP. Correlation analysis revealed significant feedback (r=-0,41, p<0,05) between galectin-3 and left ventricular EF only in patients with preserved systolic function. In the same group of HFpEF patients, the maximum values of serum galectin-3 indices were noted, reaching 10,5 [6,5; 14,5] ng/ml.Conclusion. Analysis of neurohormonal activity demonstrated a unidirectional increase in NT-proBNP and galectin-3 in patients with HF, regardless of left ventricular EF, while the maximum values of galetin-3 were observed in patients with HFpEF.

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Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

Подзолков

¹

,

Dragomiretskaya

²

,

Kazadaeva

³

et al. 2022

Russ J Cardiol

4

0

View full text Add to dashboard Cite

The introduction of novel biomarkers necessitates their detailed study in patients with different heart failure (HF) phenotypes as part of a personalized approach to assessing the disease severity and predicting outcomes.Aim. To assessthe activity of following neurohormonal systems: N-terminal probrain natriuretic peptide (NT-proBNP) and galectin-3 in HF with preserved, mildly reduced and reduced ejection fraction (EF).Material and methods. In 69 patients with NYHA class II-IV HF, along with a general clinical examination, the level of NT-proBNP and serum galectin-3 was determined by enzyme immunoassay.Results. Patients included in the study were divided into 3 groups: preserved EF (HFpEF) — 23 patients, mildly reduced EF (HFmrEF) — 26 patients, and reduced EF (HFrEF) — 20 patients. In patients with HF, the level of galectin-3 did not directly depend on EF, but was associated with NT-proBNP level as follows: there was a tendency to increase the concentration of galectin-3 in the tertile groups of NT-proBNP. Correlation analysis revealed significant feedback (r=-0,41, p<0,05) between galectin-3 and left ventricular EF only in patients with preserved systolic function. In the same group of HFpEF patients, the maximum values of serum galectin-3 indices were noted, reaching 10,5 [6,5; 14,5] ng/ml.Conclusion. Analysis of neurohormonal activity demonstrated a unidirectional increase in NT-proBNP and galectin-3 in patients with HF, regardless of left ventricular EF, while the maximum values of galetin-3 were observed in patients with HFpEF.

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Prognostic Significance of Galectin-3 Measurement in Patients With Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease

Cited by 3 publications

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Circulating biological markers of obesity: towards a systems approach

Circulating biological markers of obesity: towards a systems approach

Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

Relationships between the activity of neurohormonal systems and intracardiac hemodynamics in patients with heart failure: focus on galectin-3

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