Prognostic significance of frailty in older patients with hip fracture: a systematic review and meta-analysis

Yan, Bingzi; Sun, Wanting; Wang, Wen; Wu, Jiarui; Wang, Guanglin; Dou, Qingyu

doi:10.1007/s00264-022-05605-9

Cited by 18 publications

(12 citation statements)

References 78 publications

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“…Furthermore, the development of POD exacerbates the negative effect that frailty exerts on patient function at 4-month follow-up. Two recent systematic reviews that included older patients undergoing HF surgery, predominantly examined the association of frailty with mortality, length of hospital stay, risk of complications after surgery, and risk of institutionalization, whereas functional status was relatively understudied [26,27].…”

Section: Discussionmentioning

confidence: 99%

Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study

Gandossi,

Zambon,

Ferrara

et al. 2023

Aging Clin Exp Res

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Background This study analyzes the effect of frailty and Post-Operative Delirium (POD) on the functional status at hospital discharge and at 4-month follow-up in patients with hip fracture (HF). Methods Multicenter prospective observational study of older patients with HF admitted to 12 Italian Orthogeriatric centers (July 2019-August 2022). POD was assessed using the 4AT. A 26-item Frailty Index (FI) was created using data collected on admission. The outcome measures were Cumulated Ambulation Score (CAS) ≤ 2 at discharge and a telephone-administered CAS ≤ 2 after 4 months. Poisson regression models were used to assess the effect of frailty and POD on outcomes. Results 984 patients (median age 84 years, IQR = 79–89) were recruited: 480 (48.7%) were frail at admission, 311 (31.6%) developed POD, and 158 (15.6%) had both frailty and POD. In a robust Poisson regression, frailty alone (Relative Risk, RR = 1.56, 95% Confidence Intervals, CI 1.19–2.04, p = 0.001) and its combination with POD (RR = 2.57, 95% CI 2.02–3.26, p < 0.001) were associated with poor functional status at discharge. At 4-month follow-up, the combination of frailty with POD (RR 3.65, 95% CI 1.85–7.2, p < 0.001) increased the risk of poor outcome more than frailty alone (RR 2.38, 95% CI 1.21–4.66, p < 0.001). Conclusions POD development exacerbates the negative effect that frailty exerts on functional outcomes in HF patients.

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Section: Discussionmentioning

confidence: 99%

Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study

Gandossi,

Zambon,

Ferrara

et al. 2023

Aging Clin Exp Res

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“…Therefore, those who are the most susceptible to health issues and medical complications can be eligible for treatment. A number of preventive, protective and therapeutic measures benefiting the elderly in every aspect of healthcare assistance will be taken 17 .…”

Section: Frailty and Healthcarementioning

confidence: 99%

Frailty in older women

Fonseca

Nogueira

Borges³

et al. 2023

Rev. Assoc. Med. Bras.

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“…According to Min et al, in hospitalized older patients with traumatic injury, each additional VES-13 point was associated with an increased risk of complications or death [12]. Among traumatic patients, increased frailty scores were independently connected with increased mortality [50], risk of complications, and prolonged hospitalizations [51].…”

Section: Osteoarthritis Osteoporosis and Fracturesmentioning

confidence: 99%

Cardiometabolic Disorders Are Important Correlates of Vulnerability in Hospitalized Older Adults

Kravchenko,

Korycka-Bloch,

Stephenson

et al. 2023

Nutrients

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With an increasingly aging population worldwide, the concept of multimorbidity has attracted growing interest over recent years, especially in terms of frailty, which leads to progressive multisystem decline and increased adverse clinical outcomes. The relative contribution of multiple disorders to overall frailty index in older populations has not been established so far. This study aimed to assess the association between the vulnerable elders survey-13 (VES-13) score, which is acknowledged to be one of the most widely used measures of frailty, and the most common accompanying diseases amongst hospitalized adults aged 60 years old and more. A total of 2860 participants with an average age of 83 years were included in this study. Multiple logistic regression with adjustment for age and nutritional status was used to assess the independent impact of every particular disease on vulnerability. Diabetes mellitus type 2, coronary artery disease, atrial fibrillation, heart failure, chronic kidney disease, osteoarthritis, fractures, eyes disorders, depression, dementia, pressure ulcers, and urinary incontinence were associated with higher scores of VES-13. Hospital admission of older subjects with those conditions should primarily draw attention to the risk of functional decline, especially while qualifying older patients for further treatment in surgery and oncology. At the same time, lipid disorders, gastrointestinal diseases, higher body mass index, and albumins level were related to a lower risk of being vulnerable, which may be attributed to a younger age and better nutritional status of those patients.

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Prognostic significance of frailty in older patients with hip fracture: a systematic review and meta-analysis

Cited by 18 publications

References 78 publications

Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study

Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study

Frailty in older women

Cardiometabolic Disorders Are Important Correlates of Vulnerability in Hospitalized Older Adults

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