Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma

Abstract

Fascin-1 and E-cadherin, both of which are related to cell motility and cell adhesiveness, are important factors in the progression and metastasis of cancers. The objective of this study was to explore the association between fascin-1 and E-cadherin expression levels with both the clinical characteristics and prognoses of patients with laryngeal squamous cell carcinoma; we did so through statistical analyses. In our study, tumor tissue samples from 150 patients with laryngeal squamous cell carcinoma were examined for fascin-1 and E-cadherin expression by immunohistochemistry. Fascin-1 expression was found to be an independent predictive factor for recurrence in patients with laryngeal squamous cell carcinoma (P = 0.021) and independently related to disease-free survival (P = 0.010). Although E-cadherin expression status was not an independent predictive factor for recurrence (P = 0.055) or disease-free survival (P = 0.063), when using subgroup analysis, the subgroup with high fascin-1 expression/low E-cadherin expression had the poorest prognosis (P = 0.000). Fascin-1 expression could be a potential prognostic predictor for patients with laryngeal squamous cell carcinoma. Simultaneous analyses of fascin-1 and E-cadherin expression could be more effective in evaluating the prognoses of patients with laryngeal squamous cell carcinoma.

Specificity protein 1 regulates fascin expression in esophageal squamous cell carcinoma as the result of the epidermal growth factor/extracellular signal-regulated kinase signaling pathway activation

“…Since the overexpression of fascin has been well established in various human carcinomas examined to date [7][8][9][10][11][12][13][14][15][16], fascin has been identified as a new indicator of aggressive phenotypes and poor prognosis in malignant human epithelial carcinomas [7][8][9][10][11][12][13][14][15][16][17][18][19]. Besides its significance as an important tumor-promoting factor, convincing evidence also implicates fascin as a novel target for metastasis prevention [10].…”

“…Considering that fascin expression is quite low or absent in normal epithelial cells, while being significantly elevated in a variety of cancers [7][8][9][10][11][12][13][14][15], we believed that fascin expression could be induced by factors which could activate ERK1/2-Sp1 pathway. It was reported that both EGF and TGF-b1 induced target gene expressions through the activation of ERK1/2 and Sp1 [37,38].…”

“…Fascin is a cytoplasmic protein functioning to form the parallel actin bundles that support the lamellipodial and filopodial cell protrusions, which are key cellular structures for environmental guidance and cell migration [5,6]. The overexpression of fascin has been reported in various human carcinomas examined to date [7][8][9][10][11][12][13][14][15]. High expression levels of fascin in various primary carcinomas were consistently shown to correlate with aggressive tumor phenotypes and poor prognosis [7][8][9][10][11][12][13][14][15].…”

“…The overexpression of fascin has been reported in various human carcinomas examined to date [7][8][9][10][11][12][13][14][15]. High expression levels of fascin in various primary carcinomas were consistently shown to correlate with aggressive tumor phenotypes and poor prognosis [7][8][9][10][11][12][13][14][15]. In esophageal squamous cell carcinomas (ESCCs), fascin was reported to also be overexpressed and its increased expression was associated with the poor prognosis of ESCC patients [16].…”

Fascin

“…In some cases, high fascin expression has been correlated with low E-cadherin (epithelial cadherin) expression, indicating that as cells progress through the epithelial to mesenchymal transition (EMT), they gain fascin whilst losing E-cadherin. 27,28 There is evidence that fascin expression is regulated by the wnt activated LEF-TCF transcriptional signalling pathway that promotes EMT. 11 However, fascin expression is also regulated by cyclic-AMP response element binding protein (CREB) and the aryl hydrocarbon receptor (AhR).…”