Prognostic Significance of Epithelial-Mesenchymal Transition of Extracapsular Spread Tumors in Lymph Node Metastases of Head and Neck Cancer

Lee, Won Yong; Shin, Da Yong; Kim, Hye Jin; Ko, Young Hyeh; Kim, Sehoon; Jeong, Hyeong-Chai

doi:10.1245/s10434-014-3567-z

Cited by 18 publications

(12 citation statements)

References 39 publications

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“…These islands were also surrounded by CAF which were enriched for EMT‐promoting ligands. Lee et al investigated EMT marker expression in lymph nodes with and without ENE. They found that EMT was a better predictor of poor survival than ENE alone as ENE‐positive patients with a high percentage of tumour cells expressing mesenchymal markers had a five times worse survival rate compared to ENE‐negative patients.…”

Section: The Tumour Microenvironment In Enementioning

confidence: 99%

Extranodal extension in oral cancer: A role for the nodal microenvironment?

Pilborough

Lambert

Khurram

2019

J Oral Pathology Medicine

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Oral squamous cell carcinoma (OSCC) is a significant cause of morbidity and mortality worldwide and accounts for the majority of head and neck cancers. Metastasis of primary tumours, primarily to cervical lymph nodes in the neck, is associated with worsening prognosis. Furthermore, the prognosis of patients with extranodal extension of metastatic tumour from the lymph nodes into the neck tissues is particularly poor. The factors affecting this process are poorly understood, and detection is difficult pre‐surgery. Mounting evidence shows that components of the tumour microenvironment including cancer‐associated fibroblasts, vascular and lymphatic endothelial cells, the extracellular matrix and inflammatory immune cells, are important modulators of tumour behaviour in primary OSCC and other cancers. However, little is known about the lymph node microenvironment, its response to tumour presence and role in extranodal extension. In addition, there are many lymph node‐specific cell types and structures, such as fibroblast reticular cells and high endothelial venules, making the lymph node microenvironment distinct from that found at primary tumour sites, and which contribute to the nodal response to tumour presence. This review details the current knowledge regarding the lymph node tumour microenvironment in OSCC and its role in lymph node metastasis and extranodal extension and relates this to features of the primary tumour. Understanding the role that the lymph node microenvironment plays in promoting tumour development and extranodal extension may aid the identification of novel biomarkers and alternative treatment strategies to improve the prognosis of patients with advanced OSCC.

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Section: The Tumour Microenvironment In Enementioning

confidence: 99%

Extranodal extension in oral cancer: A role for the nodal microenvironment?

Pilborough

Lambert

Khurram

2019

J Oral Pathology Medicine

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“…In addition, a recent study on the role of epithelial-mesenchymal transition (EMT), which is a wellknown hallmark of metastatic potential, in the ENE of HNSCC supports our hypothesis. That study demonstrated that the extent or degree of EMT in ENE (rather than ENE in itself) was predictive of prognosis and survival (Lee et al, 2014).…”

Section: Discussionmentioning

confidence: 90%

Extranodal extension and thickness of metastatic lymph node as a significant prognostic marker of recurrence and survival in head and neck squamous cell carcinoma

Kwon

Roh

Lee

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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“…However, lymph node status classified by TNM staging system graduates in categories, in which important information might not be included and alone does not reliably predict prognosis . For example, extracapsular spread (ECS) is an additional pathological factor, which was recently integrated in the TNM staging system …”

Section: Introductionmentioning

confidence: 99%

“…9,10 For example, extracapsular spread (ECS) is an additional pathological factor, which was recently integrated in the TNM staging system. 8,11 Lymph node ratio (LNR), representing the number of positive lymph nodes to the total number of all resected lymph nodes, is an established predictor in cancers of other locations and entities including head and neck malignancies. 6,12,13 The concept of LNR seems to reflect the degree of lymph node metastasis more precise in regard to prediction of prognosis and therefore might be superior to classify metastatic spread by pN.…”

mentioning

confidence: 99%

The relevance of the lymph node ratio as predictor of prognosis is higher in HPV‐negative than in HPV‐positive oropharyngeal squamous cell carcinoma

Meyer

Meinrath

Seehawer

et al. 2017

Clinical Otolaryngology

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Prognostic Significance of Epithelial-Mesenchymal Transition of Extracapsular Spread Tumors in Lymph Node Metastases of Head and Neck Cancer

Abstract: High EMT scores of ECS tumors in LNM predict an unfavorable prognosis and systemic dissemination more accurately than the simple presence of ECS in LNM in head and neck cancer patients.

Cited by 18 publications

References 39 publications

Extranodal extension in oral cancer: A role for the nodal microenvironment?

Extranodal extension in oral cancer: A role for the nodal microenvironment?

Extranodal extension and thickness of metastatic lymph node as a significant prognostic marker of recurrence and survival in head and neck squamous cell carcinoma

The relevance of the lymph node ratio as predictor of prognosis is higher in HPV‐negative than in HPV‐positive oropharyngeal squamous cell carcinoma

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