Prognostic significance of early lymphocyte recovery after post-autografting administration of GM-CSF in non-Hodgkin's lymphoma

Long-term impact of prior rituximab therapy and early lymphocyte recovery on auto-SCT outcome for diffuse large B-cell lymphoma

“…We, however, report our analysis in a large homogenous population with the longest follow up of patients. Our results are in agreement with the published results by Tiwari et al,14 who demonstrated that the routine use of GM-CSF post transplant alters the prognostic significance of early lymphocyte recovery. 14 In DLBCL, lymphopenia at the time of diagnosis or relapse defined as an ALC of o1.0 Â 10 9 /L was an independent prognostic marker for OS.…”

Autologous SCT with a dose-reduced BU and CY regimen in older patients with non-Hodgkin's lymphoma

“…These have included BCNU or TBI combined with etoposide and CY, TBI with etoposide and CY, carmustine, cytarabine, CY and etoposide (BEAC), or BCNU, etoposide, ara-c and melphalan (BEAM). [19][20][21][22] Disease-free survival probabilities of 28-60% have been reported after autologous transplantation using these regimens. No randomized studies have compared these conditioning regimens.…”

Importance of blood graft characteristics in auto-SCT: implications for optimizing mobilization regimens

“…There are several reports suggesting lower risk of relapse and thus better PFS in patients with rapid lymphocyte recovery defined as the Optimizing blood graft content in auto-SCT E Jantunen and S Fruehauf absolute lymphocyte count on day þ 15 after stem-cell infusion. [28][29][30][31][32][33][34][35][36][37][38][39] These studies are summarized in Table 3. The number of lymphocytes within the graft infused seems to have prognostic significance potentially by affecting early lymphocyte recovery.…”

“…62 Several studies suggest that the risk of infectious complications, especially those of viral origin, is increased in patients receiving CD34 þ cell selected grafts, [63][64][65][66] although not all studies have noted this association. 58,67,68 35 NHL 274 ALC-15 independent prognostic factor for PFS and OS Joao 36 NHL/MCL 42 ALC-15 an independent prognostic factor for PFS and OS Tiwari 37 NHL 268 no association with ALC-15 and DFS or OS Porrata 39 NHL 50 NK cell recovery independent predictor for survival Porrata 28 MM 126 ALC-15 associated with better PFS and OS Hiwase 38 MM 119 ALC-30 associated with better PFS and OS Porrata 33 AL 145 ALC-15 independent prognostic factor for PFS and OS Nieto 31 MBC Optimizing blood graft content in auto-SCT E Jantunen and S Fruehauf…”