Prognostic significance of E-cadherin and Cox 2 expression in Tunisian patients with colorectal mucinous adenocarcinoma

Triki, Mouna; Kallel, Rim; Feki, J.; Mellouli, Manel; Charfi, Slim; Ayadi, Lobna; Boudawara, T.

doi:10.1016/j.anndiagpath.2020.151624

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…Previous studies have shown that the common prognostic factors, such as TNM stage, venous and lymphoid invasion, microsatellite instability (MSI) status, CEA, and CA19-9 are associated with the prognosis of MCA. [23][24][25] However, there was a need for an improved predicted efficacy. In our study, we found that stage III, high CA19-9 and high CEA were related to the worse survival.…”

Section: Discussionmentioning

confidence: 99%

Role of Chronic Inflammatory Ratios in Predicting Recurrence of Resected Patients with Stage I–III Mucinous Colorectal Adenocarcinoma

Liao

Ying

Huang

et al. 2021

CMAR

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Background: Cancer-related inflammation is the main cause of the progression of mucinous colorectal adenocarcinoma (MCA). Circulating fibrinogen-to-pre-albumin ratio (FPR) is associated with the clinical outcome in colorectal cancer (CRC). However, the prognostic role of FPR and which is the best inflammatory prognostic biomarker within MCA remain unknown. Methods: We enrolled 157 patients with stage I-III MCA in this study. Kaplan-Meier curve, Cox regression, and time-dependent receiver operation characteristic curve analysis were performed to assess the prognostic value and efficacy of the neutrophil-to-albumin ratio (NAR), neutrophil-to-pre-albumin ratio (NPAR), albumin-to-alkaline phosphatase ratio (AAPR), albumin-to-globulin ratio (AGR), albumin-to-fibrinogen ratio (AFR), and FPR in these patients. Results:: We found that NAR, NPAR, and FPR were significantly associated with unsatisfactory recurrence-free survival (RFS) in patients with stage I-III MCA, and the predicted efficacy of FPR was superior to that of the other two inflammatory biomarkers. Moreover, patients with a high combined TNM-CA199-FPR score had worse outcomes, with a high predicted efficacy of up to 0.779 (0.703-0.856). Using FPR, the patient was monitored for the recurrence up to two months earlier than that achieved using the common imaging techniques (4 vs 6 median months) in stage I-III MCA patients undergoing radical resection. Conclusion: FPR is the preferred inflammatory biomarker and commonly used for predicting and monitoring recurrence in stage I-III MCA patients. The combined TNM-CA199-FPR score is an economical, simple, effective, and independent prognostic factor for localized disease.

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Section: Discussionmentioning

confidence: 99%

Role of Chronic Inflammatory Ratios in Predicting Recurrence of Resected Patients with Stage I–III Mucinous Colorectal Adenocarcinoma

Liao

Ying

Huang

et al. 2021

CMAR

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“…Triki et al identified that only 57.5% of Tunisian patients with mucinous colorectal adenocarcinoma had positive membranous E-cadherin expression. These paradoxical findings may be explained by the difference between study groups as well as by the small number of cases of this study (29).…”

Section: Immunohistochemical Staining Of P53 Bcl-2 Bcl-xl and E-cadhe...mentioning

confidence: 56%

“…Besides, a meta-analysis configured by He et al confirmed a strong relation between loss of E-cadherin and worse survival time (46). Further Tunisian studies suggested no relationship between this protein and overall survival (29,39). These findings correlated with the report of a similar study from Egypt, demonstrating the lack of association between E-cadherin expression and survival time (27,47).…”

Section: Survival Analysismentioning

confidence: 74%

“…Another similar study from Tunisia showed controversial results. Triki et al revealed a significant association between CDH1 expression and distant metastases and venous invasion in mucinous colorectal cancer while Miladi-abdennadher et al noted a significant correlation between this protein and age at diagnosis and tumor size (29,39). The observations shown by kim and his team reported that CDH1 expression was associated to positive lymph nodes but they failed to demonstrate the correlation between this protein and distant metastasis (40).…”

Section: Correlation Between P53 Bcl-2 Bcl-xl and Ecadherin Expressio...mentioning

confidence: 99%

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Prognostic value of combining E-cadherin, p53, Bcl-2 and Bcl-xL expression and survival in Tunisian colorectal adenocarcinoma patients

Jamai¹,

kallel²,

Mekrezi³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Colorectal cancer (CRC) is a common health issue worldwide with an extremely low survival rate after relapse. This study aims to evaluate the immunohistochemical expression of p53, E-cadherin, Bcl-2 and Bcl-xL and find a potential correlation between these markers, clinicopathological factors and overall survival of colorectal cancer patients. Marker expression was immunohistochemically determined in 105 patients with colorectal adenocarcinoma from southern Tunisia, followed by statistical analysis. Positivity rate of nuclear p53, membranous E-cadherin and cytoplasmic Bcl-2 -Bcl-xL was 85.71%, 76.47%, 59.8%, and 85.71% respectively. Spearman correlation showed that p53 was significantly and positively related to E-cadherin, Bcl-2, Bcl-xL and distant metastasis. A positive significant correlation between E-cadherin and anti-apoptotic proteins was also seen. Membranous E-cadherin expression was significantly and negatively associated to poor prognosis factors including lymph node metastasis, lymph invasion, venous invasion and distant metastasis. Bcl-2 expression was significantly correlated to distant metastasis. Multivariate analysis showed a significant association between dependent variable Ecadherin and covariates including differentiation, lymph invasion, venous invasion, distant metastasis, Bcl-2 and Bcl-xL. Poor 3-years OS and 5-years OS were significantly related to p53, Bcl-2 expression and E-cadherin loss. Positive E-cadherin combined with negative p53 and Bcl-2 as well as doublepositive for E-cadherin and Bcl-xL were associated to best overall survival. Although each protein can be an independent prognostic factor, Simultaneous E-cadherin, p53, Bcl-2, Bcl-xL expression could be a crucial prognostic and overall survival marker to CRC patients. Multivariate analysis confirmed a positive correlation between membranous E-cadherin loss and colorectal cancer severity.

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Effect of E-cadherin on Prognosis of Colorectal Cancer: A Meta-Analysis Update

et al. 2022

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Prognostic significance of E-cadherin and Cox 2 expression in Tunisian patients with colorectal mucinous adenocarcinoma

Cited by 5 publications

References 26 publications

Role of Chronic Inflammatory Ratios in Predicting Recurrence of Resected Patients with Stage I–III Mucinous Colorectal Adenocarcinoma

Role of Chronic Inflammatory Ratios in Predicting Recurrence of Resected Patients with Stage I–III Mucinous Colorectal Adenocarcinoma

Prognostic value of combining E-cadherin, p53, Bcl-2 and Bcl-xL expression and survival in Tunisian colorectal adenocarcinoma patients

Effect of E-cadherin on Prognosis of Colorectal Cancer: A Meta-Analysis Update

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